Abstract:
OBJECTIVES:This study sought to determine the prognostic value of B-type natriuretic peptide (BNP) in patients with heart failure with preserved ejection fraction (HFPEF), in comparison to data in HF patients with reduced left ventricular (LV) EF (≤40%). BACKGROUND:Management of patients with HFPEF is difficult. BNP is a useful biomarker in patients with reduced LVEF, but data in HFPEF are scarce. METHODS:In this study, 615 patients with mild to moderate HF (mean age 70 years, LVEF 33%) were followed for 18 months. BNP concentrations were measured at baseline and were related to the primary outcome, that is, a composite of all-cause mortality and HF hospitalization, and to mortality alone. The population was divided in quintiles, according to LVEF, and patients with reduced LVEF were compared with those with HFPEF. RESULTS:There were 257 patients (42%) who had a primary endpoint and 171 (28%) who died. BNP levels were significantly higher in patients with reduced LVEF than in those with HFPEF (p < 0.001). BNP was a strong predictor of outcome, but LVEF was not. Importantly, if similar levels of BNP were compared across the whole spectrum of LVEF, and for different cutoff levels of LVEF, the associated risk of adverse outcome was similar in HFPEF patients as in those with reduced LVEF. CONCLUSIONS:BNP levels are lower in patients with HFPEF than in patients with HF with reduced LVEF, but for a given BNP level, the prognosis in patients with HFPEF is as poor as in those with reduced LVEF.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
van Veldhuisen DJ,Linssen GC,Jaarsma T,van Gilst WH,Hoes AW,Tijssen JG,Paulus WJ,Voors AA,Hillege HLdoi
10.1016/j.jacc.2012.12.044subject
Has Abstractpub_date
2013-04-09 00:00:00pages
1498-506issue
14eissn
0735-1097issn
1558-3597pii
S0735-1097(13)00484-1journal_volume
61pub_type
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