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Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry.

Abstract：

OBJECTIVES:The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term. BACKGROUND:Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients. METHODS:The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010. RESULTS:Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction <30%), the presence of moderate/severe aortic regurgitation, and chronic obstructive pulmonary disease remained the only independent predictors of mortality in the multivariate model. CONCLUSIONS:Midterm to long-term survival after TAVI was encouraging in this high-risk patient population, although a substantial proportion of patients died within the first year.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Moat NE,Ludman P,de Belder MA,Bridgewater B,Cunningham AD,Young CP,Thomas M,Kovac J,Spyt T,MacCarthy PA,Wendler O,Hildick-Smith D,Davies SW,Trivedi U,Blackman DJ,Levy RD,Brecker SJ,Baumbach A,Daniel T,Gray H,Mulle

doi

10.1016/j.jacc.2011.08.050

subject

Has Abstract

pub_date

2011-11-08 00:00:00

pages

2130-8

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(11)03339-0

journal_volume

pub_type

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Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry.