Comparison of maximal myocardial blood flow during adenosine infusion with that of intravenous dipyridamole in normal men.

Abstract:

OBJECTIVE:This study compared quantitatively the efficacy of intravenous adenosine and dipyridamole for pharmacologic induction of myocardial hyperemia. BACKGROUND:Pharmacologic vasodilation is used increasingly for induction of myocardial hyperemia in conjunction with radionuclide imaging of myocardial blood flow. Although both intravenous dipyridamole and adenosine have been used, the magnitude of hyperemia induced by these agents and the hyperemia to baseline blood flow ratios have not been quantified and compared. METHODS:Twenty normal volunteers were studied with dynamic positron emission tomography (PET) and intravenous nitrogen-13 ammonia. Myocardial blood flow was quantified with a two-compartment tracer kinetic model. RESULTS:Myocardial blood flow at rest averaged 1.1 +/- 0.2 ml/min per g and increased significantly to 4.4 +/- 0.9 ml/min per g during adenosine and 4.3 +/- 1.3 ml/min per g after dipyridamole administration. Hyperemia to baseline flow ratios averaged 4.3 +/- 1.6 for adenosine and 4.0 +/- 1.3 for dipyridamole. The average flow ratios and the maximal flows achieved were similar for both agents, but there was considerable variation in the individual response to these agents, as indicated by the range of hyperemia to baseline flow ratios (from 2.0 to 8.4 for adenosine and from 1.5 to 5.8 for dipyridamole). In addition, the hyperemic responses to dipyridamole and to adenosine differed by greater than 1 ml/min per g in nine subjects. CONCLUSIONS:Despite these inter- and intraindividual differences, we conclude that both agents are equally effective in producing myocardial hyperemia.

journal_name

J Am Coll Cardiol

authors

Chan SY,Brunken RC,Czernin J,Porenta G,Kuhle W,Krivokapich J,Phelps ME,Schelbert HR

doi

10.1016/0735-1097(92)90201-w

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

979-85

issue

4

eissn

0735-1097

issn

1558-3597

pii

0735-1097(92)90201-W

journal_volume

20

pub_type

杂志文章
  • Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative.

    abstract:OBJECTIVES:The purpose of this study was to establish the prognostic value of measuring heart fatty acid-binding protein (H-FABP) in patients with suspected acute coronary syndrome (ACS) (in particular, low- to intermediate-risk patients), in addition to troponin measured with the latest third-generation troponin assay...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2009.12.062

    authors: Viswanathan K,Kilcullen N,Morrell C,Thistlethwaite SJ,Sivananthan MU,Hassan TB,Barth JH,Hall AS

    更新日期:2010-06-08 00:00:00

  • A guide to therapeutic decision-making in patients with non-ST-segment elevation acute coronary syndromes.

    abstract::Recent clinical trial evidence supports an inflammatory etiology in acute ischemic heart disease. When a segment of coronary artery becomes inflamed, important cytokines, such as tissue factor, are released, facilitating thrombosis. Serum inflammatory markers are elevated in most acute coronary syndrome patients at pr...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0735-1097(02)02689-x

    authors: Topol EJ

    更新日期:2003-02-19 00:00:00

  • The histology of viable and hibernating myocardium in relation to imaging characteristics.

    abstract:OBJECTIVES:This study characterizes the histology of myocardium predicted to be hibernating using three different imaging techniques to explain the discordance among them. BACKGROUND:Both radionuclide and functional imaging techniques were used to assess myocardial hibernation. The former have high sensitivity and the...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01766-1

    authors: Gunning MG,Kaprielian RR,Pepper J,Pennell DJ,Sheppard MN,Severs NJ,Fox KM,Underwood SR

    更新日期:2002-02-06 00:00:00

  • Products of myocardial ischemia and electrical instability of the heart.

    abstract::Products of ischemic metabolism can make a major contribution to electrical instability of the heart. In particular, enhanced extracellular potassium slows conduction, thereby predisposing to reentrant circuits, especially when levels of cyclic adenosine monophosphate (AMP) increase in the early ischemic period. Other...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0735-1097(85)80549-0

    authors: Opie LH

    更新日期:1985-06-01 00:00:00

  • Finding the Gatekeeper to the Cardiac Catheterization Laboratory: Coronary CT Angiography or Stress Testing?

    abstract::Functional capacity is a robust predictor of clinical outcomes, and stress testing is used in current practice paradigms to guide referral to invasive coronary angiography. However, invasive coronary angiography is driven by ongoing symptoms, as well as risk of adverse outcomes. The limitations of current functional t...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2015.04.060

    authors: Marwick TH,Cho I,Ó Hartaigh B,Min JK

    更新日期:2015-06-30 00:00:00

  • Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?

    abstract:OBJECTIVES:We sought to determine whether patients receiving chronic clopidogrel therapy undergoing nonemergent stenting who display high on-treatment preprocedural platelet aggregation measured by standard light transmittance aggregometry and thrombelastography (TEG) will be at increased risk for poststenting ischemic...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2006.10.050

    authors: Bliden KP,DiChiara J,Tantry US,Bassi AK,Chaganti SK,Gurbel PA

    更新日期:2007-02-13 00:00:00

  • Anisoylated plasminogen streptokinase activator complex in acute myocardial infarction: a placebo-controlled arteriographic coronary recanalization study.

    abstract::Anisoylated plasminogen streptokinase activator complex (APSAC) is a new thrombolytic agent that is of interest because of its ease of administration as an intravenous bolus injection. This report describes the first double-blind, placebo-controlled evaluation of intravenous APSAC for coronary recanalization in acute ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0735-1097(87)80181-x

    authors: Timmis AD,Griffin B,Crick JC,Sowton E

    更新日期:1987-07-01 00:00:00

  • Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy.

    abstract:OBJECTIVES:The aim of this study was to evaluate the efficacy and safety of mipomersen in hypercholesterolemic subjects taking stable statin therapy. BACKGROUND:Mipomersen is an apolipoprotein (apo) B synthesis inhibitor that has demonstrated significant reductions in apo B and low-density lipoprotein (LDL) cholestero...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jacc.2009.11.069

    authors: Akdim F,Stroes ES,Sijbrands EJ,Tribble DL,Trip MD,Jukema JW,Flaim JD,Su J,Yu R,Baker BF,Wedel MK,Kastelein JJ

    更新日期:2010-04-13 00:00:00

  • A patient with new Q waves: methods for decision making in the individual patient.

    abstract::Decision analysis, an analytic approach to making decisions when uncertainty is present, has its foundation in probability and utility theory. It provides insights into the trade-offs that are involved when a selection must be made among patient management strategies. In general, several broad steps are involved. The ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(89)90159-9

    authors: Moskowitz AJ,Pauker SG

    更新日期:1989-09-01 00:00:00

  • Development of Quality Metrics in Ambulatory Pediatric Cardiology.

    abstract::The American College of Cardiology Adult Congenital and Pediatric Cardiology (ACPC) Section had attempted to create quality metrics (QM) for ambulatory pediatric practice, but limited evidence made the process difficult. The ACPC sought to develop QMs for ambulatory pediatric cardiology practice. Five areas of interes...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2016.11.043

    authors: Chowdhury D,Gurvitz M,Marelli A,Anderson J,Baker-Smith C,Diab KA,Edwards TC,Hougen T,Jedeikin R,Johnson JN,Karpawich P,Lai W,Lu JC,Mitchell S,Newburger JW,Penny DJ,Portman MA,Satou G,Teitel D,Villafane J,Williams

    更新日期:2017-02-07 00:00:00

  • Perioperative morbidity and mortality after transmyocardial laser revascularization: incidence and risk factors for adverse events.

    abstract:OBJECTIVES:The purpose of this study was to describe the incidence and spectrum of perioperative cardiac and noncardiac morbidity and mortality after transmyocardial laser revascularization (TMR) and to identify predictors of these adverse clinical events. BACKGROUND:Clinical studies have demonstrated the efficacy of ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00676-7

    authors: Hughes GC,Landolfo KP,Lowe JE,Coleman RB,Donovan CL

    更新日期:1999-03-15 00:00:00

  • Stem Cell-Derived Cardiomyocytes and Beta-Adrenergic Receptor Blockade in Duchenne Muscular Dystrophy Cardiomyopathy.

    abstract:BACKGROUND:Although cardiomyopathy has emerged as a leading cause of death in Duchenne muscular dystrophy (DMD), limited studies and therapies have emerged for dystrophic heart failure. OBJECTIVES:The purpose of this study was to model DMD cardiomyopathy using DMD patient-specific human induced pluripotent stem cell (...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2019.12.066

    authors: Kamdar F,Das S,Gong W,Klaassen Kamdar A,Meyers TA,Shah P,Ervasti JM,Townsend D,Kamp TJ,Wu JC,Garry MG,Zhang J,Garry DJ

    更新日期:2020-03-17 00:00:00

  • Effective prevention of atrial fibrillation by continuous atrial overdrive pacing after coronary artery bypass surgery.

    abstract:OBJECTIVES:The present study was aimed to evaluate the efficacy of a specific algorithm with continuous atrial dynamic overdrive pacing to prevent atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery. BACKGROUND:Atrial fibrillation occurs in 30% to 40% of patients after cardiac surgery with a pea...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0735-1097(00)00608-2

    authors: Blommaert D,Gonzalez M,Mucumbitsi J,Gurné O,Evrard P,Buche M,Louagie Y,Eucher P,Jamart J,Installé E,De Roy L

    更新日期:2000-05-01 00:00:00

  • Circadian variability in the occurrence of sudden cardiac death in patients with hypertrophic cardiomyopathy.

    abstract:OBJECTIVES:The present study examined whether sudden death in patients with hypertrophic cardiomyopathy occurred with a particular pattern of frequency throughout the day. BACKGROUND:Previous investigators have shown a circadian distribution in the occurrence of sudden death and other cardiovascular events in patients...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90384-0

    authors: Maron BJ,Kogan J,Proschan MA,Hecht GM,Roberts WC

    更新日期:1994-05-01 00:00:00

  • Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction.

    abstract:BACKGROUND:Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin-angiotensin-aldosterone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy when administered via osmotic mini-pump. Here, we investigate whether gene transfer of Ang-(1-9) is ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2016.09.946

    authors: Fattah C,Nather K,McCarroll CS,Hortigon-Vinagre MP,Zamora V,Flores-Munoz M,McArthur L,Zentilin L,Giacca M,Touyz RM,Smith GL,Loughrey CM,Nicklin SA

    更新日期:2016-12-20 00:00:00

  • A randomized controlled trial of a paclitaxel-eluting stent versus a similar bare-metal stent in saphenous vein graft lesions the SOS (Stenting of Saphenous Vein Grafts) trial.

    abstract:OBJECTIVES:The aim of this study was to compare the frequency of angiographic restenosis and clinical events between a paclitaxel-eluting stent (PES) and a similar bare-metal stent (BMS) in saphenous vein graft (SVG) lesions. BACKGROUND:There are conflicting and mostly retrospective data on outcomes after drug-eluting...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jacc.2008.11.029

    authors: Brilakis ES,Lichtenwalter C,de Lemos JA,Roesle M,Obel O,Haagen D,Saeed B,Gadiparthi C,Bissett JK,Sachdeva R,Voudris VV,Karyofillis P,Kar B,Rossen J,Fasseas P,Berger P,Banerjee S

    更新日期:2009-03-17 00:00:00

  • Prognostic value of serum cardiac troponin I in ambulatory patients with chronic renal failure undergoing long-term hemodialysis: a two-year outcome analysis.

    abstract:OBJECTIVES:We sought to evaluate the prognostic value of cardiac troponin I (cTnI) in asymptomatic, ambulatory patients with chronic renal failure treated with long-term hemodialysis. BACKGROUND:Smaller, short-term follow-up studies on this subject have given conflicting results. METHODS:A total of 126 ambulatory pat...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01513-3

    authors: Khan IA,Wattanasuwan N,Mehta NJ,Tun A,Singh N,Singh HK,Vasavada BC,Sacchi TJ

    更新日期:2001-10-01 00:00:00

  • Noninvasive measurement of the rest and exercise peak systolic pressure/end-systolic volume ratio: a sensitive two-dimensional echocardiographic indicator of left ventricular function.

    abstract::Thirty-five patients with previous myocardial infarction and 25 normal subjects underwent subcostal view two-dimensional echocardiography at rest and at peak up-right bicycle exercise. The purpose was to assess changes in left ventricular volume with maximal upright bicycle exercise and to compare the utility of the p...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80094-7

    authors: Ginzton LE,Laks MM,Brizendine M,Conant R,Mena I

    更新日期:1984-09-01 00:00:00

  • Precision Medicine in Patients With Resistant Hypertension and Obstructive Sleep Apnea: Blood Pressure Response to Continuous Positive Airway Pressure Treatment.

    abstract:BACKGROUND:In patients with resistant hypertension (RH) and obstructive sleep apnea (OSA), the blood pressure response to continuous positive airway pressure (CPAP) treatment is highly variable and could be associated with differential micro-ribonucleic acid (miRNA) profiles. Currently, no available methods exist to id...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jacc.2015.06.1315

    authors: Sánchez-de-la-Torre M,Khalyfa A,Sánchez-de-la-Torre A,Martinez-Alonso M,Martinez-García MÁ,Barceló A,Lloberes P,Campos-Rodriguez F,Capote F,Diaz-de-Atauri MJ,Somoza M,González M,Masa JF,Gozal D,Barbé F,Spanish Sleep Network

    更新日期:2015-09-01 00:00:00

  • Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study.

    abstract:OBJECTIVES:The goal of this study was to examine the progression of central arterial pulse pressure (cPP) in women and the degree to which this can be reversed by nitrovasodilation. BACKGROUND:cPP can be partitioned into height of the first systolic shoulder (P1), generated by a forward pressure wave and related to ar...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2011.10.871

    authors: Cecelja M,Jiang B,Spector TD,Chowienczyk P

    更新日期:2012-01-31 00:00:00

  • Cardiac complications in acquired immunodeficiency syndrome (AIDS): a review.

    abstract::Acquired immunodeficiency syndrome (AIDS) has become an increasingly important health problem worldwide. This review focuses on its cardiac complications. The key elements in the clinical syndrome are the opportunistic infections and the cancer that occur as a by-product of the immunodeficiency process. However, as ea...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0735-1097(89)90277-5

    authors: Acierno LJ

    更新日期:1989-04-01 00:00:00

  • Implications of small reference vessel diameter in patients undergoing percutaneous coronary revascularization.

    abstract:OBJECTIVES:The purpose of this study was to determine whether small reference diameter of the culprit coronary artery influences the outcome of an attempted percutaneous revascularization procedure in the current era of interventional cardiology. BACKGROUND:Although the interventional strategy is largely determined by...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(99)00181-3

    authors: Schunkert H,Harrell L,Palacios IF

    更新日期:1999-07-01 00:00:00

  • The detection of viral genomes by polymerase chain reaction in the myocardium of pediatric patients with advanced HIV disease.

    abstract:OBJECTIVES:The aim of this study was to investigate the frequency of viral nucleic acid detection in the myocardium of human immunodeficiency virus (HIV)-infected children to determine whether an association exists with the development of heart disease. BACKGROUND:As improved medical interventions increase the life ex...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(99)00264-8

    authors: Bowles NE,Kearney DL,Ni J,Perez-Atayde AR,Kline MW,Bricker JT,Ayres NA,Lipshultz SE,Shearer WT,Towbin JA

    更新日期:1999-09-01 00:00:00

  • Interventional and surgical modalities of treatment in pulmonary hypertension.

    abstract::Most patients with chronic thromboembolic pulmonary hypertension are operable, and pulmonary endarterectomy is the treatment of choice. Pulmonary endarterectomy should not be delayed for medical therapy, and risk stratification helps to define patients likely to achieve the best outcome. Inoperable patients should be ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2009.04.016

    authors: Keogh AM,Mayer E,Benza RL,Corris P,Dartevelle PG,Frost AE,Kim NH,Lang IM,Pepke-Zaba J,Sandoval J

    更新日期:2009-06-30 00:00:00

  • Doppler-detected paradoxus of mitral and tricuspid valve flows in chronic lung disease.

    abstract::An echocardiographic Doppler study in a patient with pulsus paradoxus of respiratory origin demonstrated a large inspiratory increase of tricuspid flow velocity and a corresponding decrease of mitral flow velocity. This "flow paradoxus" is therefore not specific for cardiac tamponade, and provides evidence that decrea...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(86)80205-4

    authors: Hoit B,Sahn DJ,Shabetai R

    更新日期:1986-09-01 00:00:00

  • Quality and Equitable Health Care Gaps for Women: Attributions to Sex Differences in Cardiovascular Medicine.

    abstract::The present review synthesizes evidence and discusses issues related to health care quality and equity for women, including minority population subgroups. The principle of "sameness" or women and men receiving equitable, high-quality care is a near-term target, but optimal population health cannot be achieved without ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2017.05.051

    authors: Shaw LJ,Pepine CJ,Xie J,Mehta PK,Morris AA,Dickert NW,Ferdinand KC,Gulati M,Reynolds H,Hayes SN,Itchhaporia D,Mieres JH,Ofili E,Wenger NK,Bairey Merz CN

    更新日期:2017-07-18 00:00:00

  • Influence of left ventricular hypertrophy on detection of coronary artery disease using exercise echocardiography.

    abstract:OBJECTIVES:This study examined the influence of left ventricular hypertrophy on the accuracy of exercise electrocardiography and echocardiography for detection of coronary artery disease. BACKGROUND:Electrocardiographic repolarization abnormalities caused by left ventricular hypertrophy compromise the diagnostic accur...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0735-1097(96)81472-0

    authors: Marwick TH,Torelli J,Harjai K,Haluska B,Pashkow FJ,Stewart WJ,Thomas JD

    更新日期:1995-11-01 00:00:00

  • Importance of ablating all potential right atrial flutter circuits in postcardiac surgery patients.

    abstract:OBJECTIVES:In patients with atrial flutter (AFL) and postoperative right atrial incisional scars, we sought to assess if the use of additional ablative lesions that targeted all potential re-entrant circuits, regardless of the presenting type of flutter, would prevent long-term recurrence. BACKGROUND:Patients with AFL...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.04.045

    authors: Verma A,Marrouche NF,Seshadri N,Schweikert RA,Bhargava M,Burkhardt JD,Kilicaslan F,Cummings J,Saliba W,Natale A

    更新日期:2004-07-21 00:00:00

  • Left ventricular remodeling in the year after first anterior myocardial infarction: a quantitative analysis of contractile segment lengths and ventricular shape.

    abstract::Infarct expansion after myocardial infarction results in early ventricular enlargement and distortion of ventricular geometry. To characterize the components of late volume enlargement, biplane left ventriculography was performed in 52 patients 3 weeks and 1 year after a first anterior myocardial infarction. Biplane d...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(92)90314-d

    authors: Mitchell GF,Lamas GA,Vaughan DE,Pfeffer MA

    更新日期:1992-05-01 00:00:00

  • Influence of right bundle branch block on short- and long-term survival after acute anterior myocardial infarction.

    abstract::The impact of right bundle branch block on long-term prognosis after anterior wall myocardial infarction is unclear. In 932 patients with Q wave anterior infarction, the short- and long-term prognostic significance of the presence of right bundle branch block was analyzed. Compared with 754 patients without block, 178...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(91)90865-7

    authors: Ricou F,Nicod P,Gilpin E,Henning H,Ross J Jr

    更新日期:1991-03-15 00:00:00