Abstract:
OBJECTIVES:This study sought to examine, in vivo, the shape and position of atheroma in the proximal left anterior descending coronary artery. BACKGROUND:The prevalence, shape and location of atheromas involving the proximal left anterior descending artery have implications regarding the role of disturbed shear forces in the genesis of atherosclerosis. However, no data are available regarding in vivo findings or advanced disease. METHODS:Forty-two consecutive high quality intravascular ultrasound images were examined from patients with atherosclerotic disease in the proximal left anterior descending artery just distal to the left main bifurcation. Lesion percent area stenosis and maximal, minimal and flow divider intimal-medial thickness were measured at the region immediately after the circumflex takeoff. The angle formed by the midpoint of the flow divider, the human center of gravity and the maximal plaque thickness were determined. RESULTS:Eccentricity of vessel wall atheroma was observed such that the maximal wall thickness (1.42 +/- 0.50 mm [mean +/- SD]) differed significantly from minimal wall thickness (0.17 +/- 0.098 mm). Further, the region of vessel wall manifesting maximal thickness was greater than the flow divider thickness (0.26 +/- 0.16 mm). Maximal plaque thickness spared the region of the flow divider in 100% of cases and was positioned at a mean angle of 193 +/- 49 degrees from the center of the flow divider. Eccentric morphology was maintained across the 24% to 80% range of area stenosis. CONCLUSIONS:Atheromas in the very proximal left anterior descending artery are located opposite the circumflex takeoff, spare the flow divider and maintain eccentricity across a wide range of vessel stenoses. These in vivo morphologic data support the potential role of fluid dynamic mechanical factors in atherogenesis and have implications regarding the success of catheter-based interventional procedures at the site.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Kimura BJ,Russo RJ,Bhargava V,McDaniel MB,Peterson KL,DeMaria ANdoi
10.1016/0735-1097(95)00551-xsubject
Has Abstractpub_date
1996-03-15 00:00:00pages
825-31issue
4eissn
0735-1097issn
1558-3597pii
0735-1097(95)00551-Xjournal_volume
27pub_type
杂志文章abstract:OBJECTIVES:This study sought to examine whether plasma brain natriuretic peptide levels can predict prognosis after myocardial infarction. BACKGROUND:It has been suggested that concentrations of plasma brain natriuretic peptide reflect left ventricular function. Although the prognosis after myocardial infarction depen...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(96)00067-8
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:We sought to determine whether clopidogrel is at least as efficacious as ticlopidine. BACKGROUND:Several trials have supported the enhanced safety and tolerability of clopidogrel compared with ticlopidine after coronary stent deployment. However, none of these individual trials were powered to detect possib...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/s0735-1097(01)01713-2
更新日期:2002-01-02 00:00:00
abstract:BACKGROUND:Despite being widely recognized as the most common form of secondary hypertension, among the general hypertensive population the true prevalence of primary aldosteronism (PA) and its main subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH), remains a matter of debate. OBJEC...
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更新日期:2017-04-11 00:00:00
abstract::Public reporting of hospital and individual provider quality of care measures is not a new concept. In the United States, the first national public reports of hospital mortality data occurred in 1986, and detailed physician-level data for cardiac surgery are now reported in 4 states. The development of the "Hospital C...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2013.11.050
更新日期:2014-04-08 00:00:00
abstract:OBJECTIVES:We sought to assess applicability, clinical correlates, and prognostic value of the transfer function method for measuring baroreflex sensitivity (TF-BRS). BACKGROUND:Abnormalities in autonomic reflexes play an important role in the development and progression of chronic heart failure (CHF). Simple and non-...
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doi:10.1016/j.jacc.2005.06.062
更新日期:2005-10-04 00:00:00
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doi:10.1016/j.jacc.2004.04.045
更新日期:2004-07-21 00:00:00
abstract:OBJECTIVES:The purpose of this study was to identify qualitative or quantitative variables present on angioscopy, intravascular ultrasound imaging or quantitative coronary arteriography that were associated with adverse clinical outcome after coronary intervention in high risk patients. BACKGROUND:Patients with acute ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(96)00102-7
更新日期:1996-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jacc.2009.11.080
更新日期:2010-04-20 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/0735-1097(95)00508-0
更新日期:1996-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/0735-1097(92)90070-4
更新日期:1992-01-01 00:00:00
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doi:10.1016/s0735-1097(00)00794-4
更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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更新日期:2003-04-02 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2006.08.029
更新日期:2006-11-21 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(03)00654-5
更新日期:2003-08-06 00:00:00
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更新日期:1994-01-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2000-05-01 00:00:00
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更新日期:2009-09-22 00:00:00
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更新日期:1999-04-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-10-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2007-03-20 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(86)80262-5
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-09-02 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/0735-1097(95)00605-2
更新日期:1996-04-01 00:00:00