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Homocysteine and coronary atherosclerosis.

Abstract：

:Homocysteine is increasingly recognized as a risk factor for coronary artery disease. An understanding of its metabolism and of the importance of vitamins B6 and B12 and folate as well as enzyme levels in its regulation will aid the development of therapeutic strategies that, by lowering circulating concentrations, may also lower risk. Possible mechanisms by which elevated homocysteine levels lead to the development and progression of vascular disease include effects on platelets, clotting factors and endothelium. This review presents the clinical and basic scientific evidence supporting the risk and mechanisms of vascular disease associated with elevated homocysteine concentrations as well as the results of preliminary therapeutic trials.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Mayer EL,Jacobsen DW,Robinson K

doi

10.1016/0735-1097(95)00508-0

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

517-27

issue

3

eissn

0735-1097

issn

1558-3597

pii

0735-1097(95)00508-0

journal_volume

27

pub_type

杂志文章,评审

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