当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions.

Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions.

Abstract：

:The complexity of the events that culminate in intimal proliferation after arterial injury and similarities between this response and benign neoplasia suggest that conventional medical therapies will continue to be unsuccessful in preventing recurrent stenosis after percutaneous coronary revascularization. By preventing cell division after smooth muscle cell activation, antimitogenic therapy may inhibit the final common pathway in this complex chain of events and offset the apparent loss of local growth control. Colchicine, which causes metaphase arrest of cell division, has been shown in experimental studies to decrease the extent of atheromatous plaque formation and reduce the severity of arterial restenosis after balloon angioplasty. However, preliminary results from a randomized placebo-controlled clinical trial suggest that low dose colchicine (0.6 mg twice a day orally) does not prevent restenosis. The use of more potent antineoplastic agents is limited by the potential for life-threatening side effects. It is possible that these adverse effects can be averted by using novel drug delivery systems to administer antimitogenic therapy locally at the site of arterial injury or by using low dose synergistic combinations of antiproliferative agents. This review examines the potential role of antimitogenic therapy in the prevention of restenosis after coronary interventions and considers the possibility of an overlap of the therapeutic realms of interventional cardiology and medical oncology.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Muller DW,Ellis SG,Topol EJ

doi

10.1016/0735-1097(91)90948-9

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

126B-131B

issue

6 Suppl B

eissn

0735-1097

issn

1558-3597

pii

0735-1097(91)90948-9

journal_volume

17

pub_type

杂志文章,评审

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Long-term quality of life after ablation of atrial fibrillation the impact of recurrence, symptom relief, and placebo effect.

    abstract：OBJECTIVES:We sought to determine the relationship between atrial fibrillation (AF) ablation efficacy, quality of life (QoL), and AF-specific symptoms at 2 years. BACKGROUND:Although the primary goal of AF ablation is QoL improvement, this effect has yet to be demonstrated in the long term. METHODS:A total of 502 sym...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2010.01.040

    authors： Wokhlu A,Monahan KH,Hodge DO,Asirvatham SJ,Friedman PA,Munger TM,Bradley DJ,Bluhm CM,Haroldson JM,Packer DL

    更新日期：2010-05-25 00:00:00

  • Assessment of single vessel coronary artery disease: results of exercise electrocardiography, thallium-201 myocardial perfusion imaging and radionuclide angiography.

    abstract：:The sensitivity of the commonly used stress tests for the diagnosis of coronary artery disease was analyzed in 46 patients with significant occlusion (greater than or equal to 70% luminal diameter obstruction) of only one major coronary artery and no prior myocardial infarction. In all patients, thallium-201 perfusion...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80256-4

    authors： Port SC,Oshima M,Ray G,McNamee P,Schmidt DH

    更新日期：1985-07-01 00:00:00

  • Differential localization of atrial natriuretic peptide and skeletal alpha-actin messenger RNAs in left ventricular myocytes of patients with dilated cardiomyopathy.

    abstract：OBJECTIVES:This study was designed to determine whether atrial natriuretic peptide and skeletal alpha-actin messenger RNAs (mRNAs) are co-localized in ventricular myocytes of patients with dilated cardiomyopathy. BACKGROUND:Atrial natriuretic peptide and skeletal alpha-actin are known as augmented genes with cardiac h...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00145-p

    authors： Tanaka M,Hiroe M,Ito H,Nishikawa T,Adachi S,Aonuma K,Marumo F

    更新日期：1995-07-01 00:00:00

  • Effort angina with adequate beta-receptor blockade: comparison with diltiazem alone and in combination.

    abstract：:Calcium channel blockers and beta-receptor blockers improve symptoms of myocardial ischemia by potentially different mechanisms. Accordingly, combination therapy may entail additive benefits. Twenty-four patients with symptomatic stable effort angina despite full beta-blockade were randomized to a double-blind Latin s...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(86)80500-9

    authors： Humen DP,O'Brien P,Purves P,Johnson D,Kostuk WJ

    更新日期：1986-02-01 00:00:00

  • Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism.

    abstract：OBJECTIVES:The aim of the study was to determine if isosorbide-5-mononitrate (IS-5-MN) 120 mg, taken once daily for 7 days, is associated with evidence of endothelial dysfunction and whether this effect is determined by increased free radical production. BACKGROUND:Tolerance to nitroglycerin is associated with increas...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2006.10.074

    authors： Thomas GR,DiFabio JM,Gori T,Parker JD

    更新日期：2007-03-27 00:00:00

  • Large artery stiffness predicts ischemic threshold in patients with coronary artery disease.

    abstract：OBJECTIVES:The goal of this study was to determine whether large artery stiffness contributes to exercise-induced myocardial ischemia in patients with coronary artery disease (CAD). BACKGROUND:Large artery stiffness is an independent predictor of cardiovascular mortality and a major determinant of pulse pressure and, ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02009-0

    authors： Kingwell BA,Waddell TK,Medley TL,Cameron JD,Dart AM

    更新日期：2002-08-21 00:00:00

  • Effect of rotational atherectomy in noncalcified atherosclerotic plaque: a volumetric intravascular ultrasound study.

    abstract：OBJECTIVES:This study used pre-rotational and post-rotational atherectomy volumetric intravascular ultrasound analysis to determine whether rotational atherectomy causes ablation of non-calcified atherosclerotic plaque. BACKGROUND:Rotational atherectomy is currently the preferred treatment for heavily calcified corona...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(96)00255-0

    authors： Dussaillant GR,Mintz GS,Pichard AD,Kent KM,Satler LF,Popma JJ,Leon MB

    更新日期：1996-10-01 00:00:00

  • Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) study.

    abstract：OBJECTIVES:This study sought to assess the prognostic impact of midregional pro-adrenomedullin (MR-proADM) after an acute myocardial infarction (AMI). BACKGROUND:Adrenomedullin (ADM) is elevated in heart failure (HF) and after AMI. Another part of its precursor, MR-proADM, is more stable in circulation and ex vivo. We...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.12.038

    authors： Khan SQ,O'Brien RJ,Struck J,Quinn P,Morgenthaler N,Squire I,Davies J,Bergmann A,Ng LL

    更新日期：2007-04-10 00:00:00

  • Recipient age determines the cardiac functional improvement achieved by skeletal myoblast transplantation.

    abstract：OBJECTIVES:The aim of the current study was to evaluate the effect of recipient age on the regenerative response to implantation with young skeletal myoblasts (SKMCs) after a coronary artery ligation. BACKGROUND:In contrast with previous findings in animals, the initial clinical trials of cell transplantation after a ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.06.009

    authors： Kan CD,Li SH,Weisel RD,Zhang S,Li RK

    更新日期：2007-09-11 00:00:00

  • Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status.

    abstract：OBJECTIVES:To compare seven-year survival in the Bypass Angioplasty Revascularization Investigation (BARI) patients randomly assigned to percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass grafting (CABG). BACKGROUND:The primary results of BARI reported no significant difference in five...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0735-1097(00)00533-7

    authors： BARI Investigators.

    更新日期：2000-04-01 00:00:00

  • Carotid artery vasoreactivity in response to sympathetic stress correlates with coronary disease risk and is independent of wall thickness.

    abstract：OBJECTIVES:We designed a study to determine the carotid artery (CA) response to sympathetic activity and to determine whether the response correlates with coronary risk and is independent of wall thickness (IMT). BACKGROUND:Brachial artery reactivity in response to wall stress correlates with coronary risk and coronar...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)01021-4

    authors： Rubenfire M,Rajagopalan S,Mosca L

    更新日期：2000-12-01 00:00:00

  • Substance P potentiates the algogenic effects of intraarterial infusion of adenosine.

    abstract：OBJECTIVES:This study investigated whether substance P potentiates the muscular and cardiac pain caused by the intraarterial infusion of adenosine, an autocoid known to induce muscular and cardiac ischemic-like pain in humans. BACKGROUND:Substance P is involved in the generation of neurogenic inflammation and causes c...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0735-1097(94)90306-9

    authors： Gaspardone A,Crea F,Tomai F,Iamele M,Crossman DC,Pappagallo M,Versaci F,Chiariello L,Gioffrè PA

    更新日期：1994-08-01 00:00:00

  • Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy.

    abstract：OBJECTIVES:The goal of this pre-clinical study was to assess the therapeutic efficacy of doxycycline (Doxy) for desmin-related cardiomyopathy (DRC) and to elucidate the potential mechanisms involved. BACKGROUND:DRC, exemplifying cardiac proteinopathy, is characterized by intrasarcoplasmic protein aggregation and cardi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2010.01.075

    authors： Zheng H,Tang M,Zheng Q,Kumarapeli AR,Horak KM,Tian Z,Wang X

    更新日期：2010-10-19 00:00:00

  • Patient characteristics associated with care by a cardiologist among adults hospitalized with severe congestive heart failure. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments.

    abstract：OBJECTIVES:The goal of this study was to determine factors associated with receiving cardiologist care among patients with an acute exacerbation of congestive heart failure. BACKGROUND:Because cardiologist care for acute cardiovascular illness may improve care, barriers to specialty care could impact patient outcomes....

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0735-1097(00)01005-6

    authors： Auerbach AD,Hamel MB,Califf RM,Davis RB,Wenger NS,Desbiens N,Goldman L,Vidaillet H,Connors AF,Lynn J,Dawson NV,Phillips RS

    更新日期：2000-12-01 00:00:00

  • Diagnostic accuracy of transesophageal echocardiography during cardiopulmonary resuscitation.

    abstract：OBJECTIVES:We sought to establish the diagnostic accuracy of transesophageal echocardiography (TEE) during cardiopulmonary resuscitation. BACKGROUND:Because of its bedside diagnostic capabilities, excellent cardiac images and lack of interference with resuscitation efforts, TEE is ideally suited to determine the cause...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0735-1097(97)00218-0

    authors： van der Wouw PA,Koster RW,Delemarre BJ,de Vos R,Lampe-Schoenmaeckers AJ,Lie KI

    更新日期：1997-09-01 00:00:00

  • Multivessel Palmaz-Schatz stenting: early results and one-year outcome.

    abstract：OBJECTIVES:To determine whether the benefits outlined in Background might extend to patients with multivessel disease, we examined the short- and long-term outcome of multivessel Palmaz-Schatz stenting. BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) has become the dominant treatment for most patients...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00146-0

    authors： Laham RJ,Ho KK,Baim DS,Kuntz RE,Cohen DJ,Carrozza JP Jr

    更新日期：1997-07-01 00:00:00

  • Right coronary artery-pulmonary artery arteriovenous fistula secondary to open heart surgery.

    abstract：:A patient is described who underwent atrial septal defect repair at age 12 and presented 16 years later with angina. Coronary angiography revealed a right coronary artery to pulmonary artery fistula that had developed at the site of the previous thoracotomy. This is the first report of an acquired fistula of this type...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80509-x

    authors： Rothschild AH,Adatepe MH,Magovern GJ,Rothschild MA,Joyner CR

    更新日期：1985-10-01 00:00:00

  • Clinical and genetic issues in familial dilated cardiomyopathy.

    abstract：:Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular dilatation and systolic dysfunction after known causes have been excluded. Idiopathic dilated cardiomyopathy occurring in families, or familial dilated cardiomyopathy (FDC), may occur in 20% to 50% of IDC cases. Sixteen genes have been shown ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2004.11.066

    authors： Burkett EL,Hershberger RE

    更新日期：2005-04-05 00:00:00

  • Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4).

    abstract：OBJECTIVES:We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated with acute coronary syndrome (ACS). BACKGROUND:Tezosentan is a dual endothelin receptor antagonist that has been shown to improve cardiac output, decrease pulmonary capillary wedge pressure, an...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0735-1097(03)00194-3

    authors： O'Connor CM,Gattis WA,Adams KF Jr,Hasselblad V,Chandler B,Frey A,Kobrin I,Rainisio M,Shah MR,Teerlink J,Gheorghiade M,Randomized Intravenous TeZosentan Study-4 Investigators.

    更新日期：2003-05-07 00:00:00

  • Association of contemporary sensitive troponin I levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina: results from the LIPID Study (Long-Term Intervention With Pravastatin in Ischaemic

    abstract：OBJECTIVES:This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects of pravastatin on TnI levels. BACKGROUND:The role of troponins in predicting long-term outcomes i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2013.08.1643

    authors： White HD,Tonkin A,Simes J,Stewart R,Mann K,Thompson P,Colquhoun D,West M,Nestel P,Sullivan D,Keech AC,Hunt D,Blankenberg S,LIPID Study Investigators.

    更新日期：2014-02-04 00:00:00

  • Severe renal impairment and stroke prevention in atrial fibrillation: implications for thromboprophylaxis and bleeding risk.

    abstract：:The prevalence of atrial fibrillation (AF) in end-stage renal failure is high, with an increased risk of stroke among these patients with AF compared with the AF population without severe renal impairment. Many trials have shown the net clinical benefit of oral anticoagulation therapy for primary and secondary prevent...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2010.12.013

    authors： Marinigh R,Lane DA,Lip GY

    更新日期：2011-03-22 00:00:00

  • Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling.

    abstract：OBJECTIVES:We sought to evaluate the mechanisms that support the stability of platelet aggregates on a thrombogenic surface exposed to flowing blood. BACKGROUND:Activation of the membrane glycoprotein (GP) IIb/IIIa--mediated in part through the P2Y1 and P2Y12 adenosine 5'-diphosphate (ADP) receptors--is necessary for ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.08.055

    authors： Goto S,Tamura N,Ishida H,Ruggeri ZM

    更新日期：2006-01-03 00:00:00

  • Management of ventricular arrhythmias: a trial-based approach.

    abstract：:Sudden cardiac death accounts for approximately 300,000 deaths annually in the U.S., and most of these are secondary to ventricular tachycardia (VT) and fibrillation in patients with coronary artery disease. Most patients with cardiac death die before reaching the hospital, which brought about a tremendous amount of r...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(99)00273-9

    authors： Welch PJ,Page RL,Hamdan MH

    更新日期：1999-09-01 00:00:00

  • Incidence, Characteristics, Predictors, and Outcomes of Surgical Explantation After Transcatheter Aortic Valve Replacement.

    abstract：BACKGROUND:Currently, there is a paucity of information on surgical explantation after transcatheter aortic valve replacement (TAVR). OBJECTIVES:The purpose of this study was to examine the incidence, patient characteristics, predictors, and outcomes of surgical explantation after TAVR using a population-based, nation...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.08.048

    authors： Hirji SA,Percy ED,McGurk S,Malarczyk A,Harloff MT,Yazdchi F,Sabe AA,Bapat VN,Tang GHL,Bhatt DL,Thourani VH,Leon MB,O'Gara P,Shah PB,Kaneko T

    更新日期：2020-10-20 00:00:00

  • Echocardiographic predictors of left ventricular outflow tract obstruction and systolic anterior motion of the mitral valve after mitral valve reconstruction for myxomatous valve disease.

    abstract：OBJECTIVE:To determine predictors of systolic anterior motion and left ventricular outflow tract obstruction (SAM/LVOTO) after mitral valve repair (MVRep) in patients with myxomatous mitral valve disease. BACKGROUND:Mechanisms for the development of SAM/LVOTO after MVRep have been described; however, predictors of thi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00464-7

    authors： Maslow AD,Regan MM,Haering JM,Johnson RG,Levine RA

    更新日期：1999-12-01 00:00:00

  • A unified functional/anatomic substrate for circus movement atrial flutter: activation and refractory patterns in the canine right atrial enlargement model.

    abstract：OBJECTIVES:This study was designed to test the concept of a functional/anatomic interaction in a canine model of reentry based on right atrial enlargement and to elucidate the electrophysiologic basis for functional conduction block. BACKGROUND:The monotonic feature of atrial flutter suggests a uniform substrate for t...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90719-h

    authors： Schoels W,Kuebler W,Yang H,Gough WB,el-Sherif N

    更新日期：1993-01-01 00:00:00

  • A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men.

    abstract：OBJECTIVES:The study evaluated the risk of cardiovascular mortality according to combined spontaneous (non-treatment-related) changes in both systolic and diastolic blood pressure (BP). BACKGROUND:Long-term longitudinal changes in blood pressure may be a more accurate determinant of cardiovascular risk since changes i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00586-0

    authors： Benetos A,Zureik M,Morcet J,Thomas F,Bean K,Safar M,Ducimetière P,Guize L

    更新日期：2000-03-01 00:00:00

  • High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease.

    abstract：OBJECTIVES:We investigated the acute effect of orally administered high-dose folic acid on coronary dilator function in humans. BACKGROUND:Folic acid and its active metabolite, 5-methyltetrahydrofolate, increase endothelium-dependent vasodilation in human peripheral circulation. However, the acute effect on coronary c...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jacc.2005.02.038

    authors： Tawakol A,Migrino RQ,Aziz KS,Waitkowska J,Holmvang G,Alpert NM,Muller JE,Fischman AJ,Gewirtz H

    更新日期：2005-05-17 00:00:00

  • Apolipoprotein E genotype: epsilon32 women are protected while epsilon43 and epsilon44 men are susceptible to ischemic heart disease: the Copenhagen City Heart Study.

    abstract：OBJECTIVES:We tested the hypothesis that risk of ischemic heart disease (IHD) differs as a function of apolipoprotein E (APOE) genotype in women and men. BACKGROUND:Apolipoprotein E genotype influences lipids and lipoproteins and, therefore, possibly the risk of IHD. METHODS:We genotyped 9,241 white women and men fro...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)00520-9

    authors： Frikke-Schmidt R,Tybjaerg-Hansen A,Steffensen R,Jensen G,Nordestgaard BG

    更新日期：2000-04-01 00:00:00

  • Human ventricular unloading induces cardiomyocyte proliferation.

    abstract：BACKGROUND:The adult mammalian heart is incapable of meaningful regeneration after substantial cardiomyocyte loss, primarily due to the inability of adult cardiomyocytes to divide. Our group recently showed that mitochondria-mediated oxidative DNA damage is an important regulator of postnatal cardiomyocyte cell cycle a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.12.027

    authors： Canseco DC,Kimura W,Garg S,Mukherjee S,Bhattacharya S,Abdisalaam S,Das S,Asaithamby A,Mammen PP,Sadek HA

    更新日期：2015-03-10 00:00:00