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High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease.

Abstract：

OBJECTIVES:We investigated the acute effect of orally administered high-dose folic acid on coronary dilator function in humans. BACKGROUND:Folic acid and its active metabolite, 5-methyltetrahydrofolate, increase endothelium-dependent vasodilation in human peripheral circulation. However, the acute effect on coronary circulation is not known. METHODS:Fourteen patients with ischemic heart disease, age 62 +/- 12 years (mean +/- SD), were enrolled in a double-blind, placebo-controlled crossover trial. Basal and adenosine-stimulated myocardial blood flow (MBF) were determined by positron emission tomography, and myocardial flow reserve was calculated. Each patient was studied after ingestion of placebo and after ingestion of 30 mg folic acid. Myocardial zones were prospectively defined physiologically as "normal" versus "abnormal" on the basis of MBF response to adenosine 140 microg/kg/min (normal = MBF >1.65 ml/min/g). Abnormal and normal zones were analyzed separately in a patient-based analysis. RESULTS:Folate was associated with a reduction in mean arterial pressure (100 +/- 12 mm Hg vs. 96 +/- 11 mm Hg, placebo vs. folate, p < 0.03). Despite the fall in mean arterial pressure, folic acid significantly increased the MBF dose response to adenosine (p < 0.001 using analysis of variance) in abnormal zones, whereas MBF in normal zones did not change. In abnormal segments, folic acid increased peak MBF by 49% (1.45 +/- 0.59 ml/min/g vs. 2.16 +/- 1.01 ml/min/g, p < 0.02). Furthermore, folate increased dilator reserve by 83% in abnormal segments (0.77 +/- 0.59 vs. ml/min/g 1.41 +/- 1.08 ml/min/g, placebo vs. folate, p < 0.05), whereas dilator reserve in normal segments remained unchanged (2.00 +/- 0.61 ml/min/g vs. 2.12 +/- 0.69 ml/min/g, placebo vs. folate, p = NS). CONCLUSIONS:The data demonstrate that high-dose oral folate acutely lowers blood pressure and enhances coronary dilation in patients with coronary artery disease.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Tawakol A,Migrino RQ,Aziz KS,Waitkowska J,Holmvang G,Alpert NM,Muller JE,Fischman AJ,Gewirtz H

doi

10.1016/j.jacc.2005.02.038

subject

Has Abstract

pub_date

2005-05-17 00:00:00

pages

1580-4

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(05)00472-9

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

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High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease.