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Increased release of nitric oxide in ischemic hearts after exercise in patients with effort angina.

Abstract：

OBJECTIVES:The aim of this study was to determine whether the release of nitric oxide (NO) from the ischemic heart increases during exercise in patients with effort angina. BACKGROUND:Myocardial ischemia increases NO production in the canine heart, but no such increase has been demonstrated in the ischemic human heart. METHODS:Fifteen patients with effort angina underwent supine ergometer exercise tests. All patients had severe proximal stenosis (>90%) in the left anterior descending coronary artery. The control group consisted of 17 subjects without coronary artery disease or systemic hemodynamic abnormalities. RESULTS:Neither the lactate extraction ratio (LER) nor the difference in NO concentration between coronary venous and arterial blood (deltaVA[NO]) was affected by exercise in the control subjects. In patients with effort angina, neither variable differed from that in the control group at rest; however, exercise markedly decreased LER and significantly increased deltaVA(NO) (from 4.7 +/- 0.3 to 16.5 +/- 1.6 micromol/liter, p < 0.001) in the patient group. The extent of decrease in LER was significantly correlated with the extent of increase in deltaVA(NO) in the patients with effort angina (r2 = -0.837, p < 0.001). CONCLUSIONS:Provocation of myocardial ischemia by exercise stress increases NO production in the hearts of patients with effort angina.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Node K,Kitakaze M,Sato H,Koretsune Y,Karita M,Kosaka H,Hori M

doi

10.1016/s0735-1097(98)00196-x

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

63-8

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(98)00196-X

journal_volume

32

pub_type

杂志文章

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