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Cardiometabolic consequences of gestational dysglycemia.

Abstract：

:The development of gestational diabetes and even milder forms of dysglycemia during pregnancy represents a maternal phenotype at increased subsequent risk for developing type 2 diabetes mellitus, metabolic syndrome, and, with time, overt cardiovascular disease. A careful and systematic dissection of the hormonal, metabolic, and vascular changes occurring in such women during pregnancy and over the postpartum years provides a unique opportunity to identify conventional and novel conditions and biomarkers whose modification may attenuate adverse long-term outcomes, particularly cardiovascular risk. The purpose of this review is to summarize current understanding of the magnitude of such risk and its potential causes, with a particular focus on postpartum alterations in endothelial and vascular smooth muscle responsiveness.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Brewster S,Zinman B,Retnakaran R,Floras JS

doi

10.1016/j.jacc.2013.01.080

subject

Has Abstract

pub_date

2013-08-20 00:00:00

pages

677-84

issue

8

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(13)01100-5

journal_volume

62

pub_type

杂志文章,评审

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