Abstract：
:Though he received his medical education in Edinburgh, William Withering was born and bred, and conducted his practice, in the Midlands of England, where he collaborated closely with medical and nonmedical colleagues who were pioneers of intellectual thought during the industrial revolution. Because of his profound botanical knowledge, he was able to identify Digitalis purpurea as the essential ingredient in a prescription dispensed by a herbalist, and systematically proceeded to show its value in patients with cardiac failure. He identified the cardinal symptoms of digitalis intoxication and worked out effective rules for the prescription of an infusion of digitalis. Withering's careful observations were also extended to botany and geology, and he was a key figure in the intellectual and scientific life of his area, a man whose legacy is not only the agent he identified but also the scrupulous way in which he evaluated it.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Krikler DMdoi
10.1016/s0735-1097(85)80457-5subject
Has Abstractpub_date
1985-05-01 00:00:00pages
3A-9Aissue
5 Suppl Aeissn
0735-1097issn
1558-3597journal_volume
5pub_type
传,历史文章,杂志文章abstract：OBJECTIVES:The aim of this study was to compare outcomes after transfemoral transcatheter aortic valve implantation with the Medtronic CoreValve (MCV) versus the Edwards SAPIEN/SAPIEN XT transcatheter heart valve (ESV) for severe aortic stenosis. BACKGROUND:No large matched comparison study has been conducted so far e...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jacc.2012.11.050
更新日期：2013-02-26 00:00:00
abstract：:Hypertension accounts for 1 in 5 deaths among American women, posing a greater burden for women than men, and is among their most important risk factors for death and development of cardiovascular and other diseases. Hypertension affects women in all phases of life, with specific characteristics relating to risk facto...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2018.02.033
更新日期：2018-04-24 00:00:00
abstract：:Several studies in the prethrombolytic era on the treatment of acute myocardial infarction identified selected variables from the patient's history, physical examination, chest roentgenogram and electrocardiogram that could be used to estimate mortality in patients with evolving infarction. To extend such assessment t...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(90)90579-e
更新日期：1990-08-01 00:00:00
abstract：OBJECTIVES:The goal of this work was to explore the treatment and outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) age > or =90 years. BACKGROUND:The elderly are often excluded from clinical trials of NSTE-ACS and are underrepresented in clinical registries. METHODS:We used data ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.01.066
更新日期：2007-05-01 00:00:00
abstract：:Nicardipine, a new dihydropyridine calcium channel blocker, has been investigated for the treatment of coronary artery disease and heart failure. To assess the inotropic effect of nicardipine in humans independent of its vasodilator effect, equihypotensive doses of intravenous nitroprusside (mean infusion rate 65 +/- ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(89)90437-3
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVES:This study used pre-rotational and post-rotational atherectomy volumetric intravascular ultrasound analysis to determine whether rotational atherectomy causes ablation of non-calcified atherosclerotic plaque. BACKGROUND:Rotational atherectomy is currently the preferred treatment for heavily calcified corona...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(96)00255-0
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Early in the prevention and treatment of bioprosthetic valve thrombosis (BPVT), anticoagulation is effective, but the long-term outcome after BPVT is unknown. OBJECTIVES:The goal of this study was to assess the long-term outcomes of patients with BPVT treated with anticoagulation. METHODS:This analysis was...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2019.12.037
更新日期：2020-03-03 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the significance of non-type 1 anterior early repolarization (NT1-AER) combined with inferolateral early repolarization syndrome (ERS). BACKGROUND:Inferolateral ERS might be a heterogeneous entity, although it excludes type 1 Brugada syndrome (BS). METHODS:Of 84 pat...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2013.05.081
更新日期：2013-10-22 00:00:00
abstract：OBJECTIVES:This study sought to evaluate the ability of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab to reduce the risk of complex coronary atherosclerosis requiring revascularization. BACKGROUND:PCSK9 inhibitors induce plaque regression and reduce the risk of coronary revascularizati...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2020.11.011
更新日期：2021-01-26 00:00:00
abstract：:Nuclear magnetic resonance (NMR) imaging has been shown to accurately portray cardiac anatomy and function. To investigate the potential of NMR imaging for the assessment of coronary stenosis in patients with chest pain, ultrafast NMR imaging in conjunction with a T1 (longitudinal relaxation time) contrast agent was p...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(91)90754-w
更新日期：1991-10-01 00:00:00
abstract：:Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a few years of follow-up, but patients are often given continuous treatment with multiple drugs well into old age. We focus on 4 commonly used cardiovascular dru...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2015.07.018
更新日期：2015-09-15 00:00:00
abstract：OBJECTIVES:The purpose of this study was to determine whether pulmonary artery responses to acetylcholine are abnormal in patients with chronic heart failure. BACKGROUND:Defective pulmonary artery endothelium-dependent responses have been observed in chronic heart failure models in animals. However, pulmonary artery e...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(93)90552-c
更新日期：1993-11-01 00:00:00
abstract：:Coronary artery reocclusion after thrombolysis with human recombinant tissue-type plasminogen activator (rt-PA) is related to the short half-life of this agent in plasma. K2P, a mutant of rt-PA lacking the fibronectin fingerlike, epidermal growth factor-like and first kringle domains (amino acids 6 to 173) and having ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(92)90164-i
更新日期：1992-07-01 00:00:00
abstract：OBJECTIVES:This study sought to analyze the outcomes of revascularization procedures in the treatment of allograft coronary disease. BACKGROUND:Allograft vasculopathy is the main factor limiting survival of heart transplant recipients. Because no medical therapy prevents allograft atherosclerosis, and retransplantatio...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/0735-1097(95)00124-i
更新日期：1995-07-01 00:00:00
abstract：:Two patients with complete heart block complicating extensive anterior myocardial infarction underwent late (greater than 40 hours) coronary reperfusion with angioplasty. One to one atrioventricular conduction was restored within minutes of reperfusion despite a lack of measurable ventricular muscle salvage as demonst...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(84)80156-4
更新日期：1984-12-01 00:00:00
abstract：OBJECTIVES:Evaluation of the severity of a coronary artery stenosis is of paramount importance for therapy. A relevant stenosis provokes post-stenotic microvascular dilation with capillary recruitment. This autoregulatory response was investigated in the present study by use of susceptibility-sensitive magnetic resonan...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(02)02931-5
更新日期：2003-03-05 00:00:00
abstract：:Although digoxin is often the first choice for control of ventricular response in chronic atrial fibrillation, it fails to slow exercise rates. Diltiazem, a calcium channel antagonist that slows atrioventricular conduction, was administered to 16 patients who failed to achieve adequate rate control on low level exerci...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(87)80396-0
更新日期：1987-02-01 00:00:00
abstract：:The sequential univalent reduction of oxygen gives rise to very reactive intermediate products including superoxide anion radical, hydrogen peroxide and free hydroxyl radicals. Normally, the tissue concentration of these intermediate products of oxygen is severely limited; however, if oxygen free radicals are produced...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(85)80278-3
更新日期：1985-07-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to determine whether residual stenoses after excimer laser angioplasty and atherectomy were due to inefficient tissue ablation/removal or to undersized devices. BACKGROUND:Significant residual stenoses are commonly observed after use of laser and atherectomy devices. It is not ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(93)90587-q
更新日期：1993-11-15 00:00:00
abstract：:The knowledge and treatment of cardiology as practiced circa 1950 is discussed as abstracted from authoritative textbooks of that time and other sources. Advances in treatment and diagnostic techniques since 1950 are presented. Dramatic changes in cardiology have come at the expense of bedside cardiology which needs t...
journal_title：Journal of the American College of Cardiology
pub_type： 历史文章,杂志文章
doi：10.1016/s0735-1097(99)00027-3
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:We examined whether mitral regurgitation (MR) augments post-myocardial infarction (MI) remodeling. BACKGROUND:MR doubles mortality after MI, but its additive contribution to left ventricular (LV) remodeling is debated and has not been addressed in a controlled fashion. METHODS:Apical MIs were created in 12...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.07.093
更新日期：2008-01-29 00:00:00
abstract：:Sudden death in healthy athletes is uncommon but, when it occurs, the primary mechanism is cardiovascular. The major cause of sudden death in the young athlete is hypertrophic cardiomyopathy or related conditions characterized by left ventricular hypertrophy, aortic rupture due to cystic medial necrosis and congenital...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/s0735-1097(86)80285-6
更新日期：1986-01-01 00:00:00
abstract：:Acquired immunodeficiency syndrome (AIDS) has become an increasingly important health problem worldwide. This review focuses on its cardiac complications. The key elements in the clinical syndrome are the opportunistic infections and the cancer that occur as a by-product of the immunodeficiency process. However, as ea...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/0735-1097(89)90277-5
更新日期：1989-04-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to clarify the impact of sex-related differences in transcatheter aortic valve implantation (TAVI) for high-risk patients with severe aortic stenosis. BACKGROUND:Although TAVI is becoming a mature technique, the impact of sex differences remains unclear. METHODS:The TAVI patie...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2011.10.877
更新日期：2012-02-07 00:00:00
abstract：OBJECTIVES:Desensitization and down-regulation of beta-adrenergic receptors (betaARs) are prominent features of heart failure largely mediated by increased levels of betaAR kinase-1 (betaARK1). BACKGROUND:beta-adrenergic receptor kinase 1 interacts with phosphoinositide-3 kinase (PI3K), and upon agonist stimulation, t...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2005.02.062
更新日期：2005-06-07 00:00:00
abstract：:The efficacy of verapamil and lidocaine for treating ischemia-induced arrhythmias was determined in a conscious canine model with a previous myocardial infarction remote from the ischemic area. Temporary (up to 5.5 minutes) occlusion of the circumflex coronary artery was made in eight conscious dogs that had sustained...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(85)80130-3
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to evaluate endothelium-dependent vasodilation and carotid intimal-medial thickness (IMT) in children with insulin-dependent diabetes mellitus. BACKGROUND:Diabetes mellitus is an established risk factor for atherosclerosis. Vascular complications of diabetes are not clinicall...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(02)02894-2
更新日期：2003-02-19 00:00:00
abstract：OBJECTIVES:The study tested whether extreme lipoprotein(a) levels and/or corresponding LPA risk genotypes improve myocardial infarction (MI) and coronary heart disease (CHD) risk prediction beyond conventional risk factors. BACKGROUND:Elevated lipoprotein(a) levels cause MI and CHD. Levels are primarily determined by ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2012.12.023
更新日期：2013-03-19 00:00:00
abstract：OBJECTIVES:We sought to demonstrate the electrophysiologic (EP) mechanism of the ST-T change in Brugada syndrome. BACKGROUND:Brugada syndrome is characterized by various electrocardiographic manifestations (e.g., right bundle branch block, ST-segment elevation, and terminal T-wave inversion in the right precordial lea...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(02)01964-2
更新日期：2002-07-17 00:00:00
abstract：:Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On the basis of single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15-year follow-up), CAC scoring has emerged as a widely available, consistent, and reproducible ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2018.05.027
更新日期：2018-07-24 00:00:00
