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Significance of non-type 1 anterior early repolarization in patients with inferolateral early repolarization syndrome.

Abstract：

OBJECTIVES:The aim of this study was to investigate the significance of non-type 1 anterior early repolarization (NT1-AER) combined with inferolateral early repolarization syndrome (ERS). BACKGROUND:Inferolateral ERS might be a heterogeneous entity, although it excludes type 1 Brugada syndrome (BS). METHODS:Of 84 patients with spontaneous ventricular fibrillation, 31 ERS patients were divided into 2 groups. The ERS(A)-group consisted of inferolateral ER and NT1-AER--that is, notching or slurring with J-wave ≥ 1 mm at the end of QRS to early ST segment in any of V1 to V3 leads, in which the ST-T segment did not change to a coved pattern in the standard and high costal (second and third) electrocardiographic recordings even after drug provocation tests (n = 12). The other, ERS(B)-group, showed only inferolateral ER (n = 19). Clinical characteristics and outcomes were compared between the ERS groups, 40 patients with type-1 BS (BS-group), and 13 patients with idiopathic ventricular fibrillation lacking J-wave (IVF-group). RESULTS:Ventricular fibrillation occurred during sleep or near sleep in 10 of 12 patients in ERS(A)-group and in 22 of 40 patients in BS-group but in 2 of 19 patients in ERS(B)-group and in 1 of 13 patients in IVF-group (ERS[A] vs. ERS[B], p < 0.0001). Ventricular fibrillation recurrence was significantly higher in ERS(A)-group (58%), particularly in patients with J waves in the high lateral lead, and BS-group (55%), compared with ERS(B)-group (11%) and IVF-group (15%) (ERS[A] vs. ERS[B], p = 0.012). CONCLUSIONS:Inferolateral ERS comprises heterogeneous ER subtypes with and without NT1-AER. Coexistence of NT1-AER was a key predictor of poor outcome in patients with ERS.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Kamakura T,Kawata H,Nakajima I,Yamada Y,Miyamoto K,Okamura H,Noda T,Satomi K,Aiba T,Takaki H,Aihara N,Kamakura S,Kimura T,Shimizu W

doi

10.1016/j.jacc.2013.05.081

subject

Has Abstract

pub_date

2013-10-22 00:00:00

pages

1610-8

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(13)02605-3

journal_volume

pub_type

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Significance of non-type 1 anterior early repolarization in patients with inferolateral early repolarization syndrome.