High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction.

Abstract:

BACKGROUND:Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability. OBJECTIVES:This study investigated the prognostic value of WSS measured in the proximal segments of lesions (WSSprox) to predict myocardial infarction (MI) in patients with stable coronary artery disease (CAD) and hemodynamically significant lesions. The authors hypothesized that in patients with low FFR and stable CAD, higher WSSprox would predict MI. METHODS:Among 441 patients in the FAME II (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation II) trial with FFR ≤0.80 who were randomized to medical therapy alone, 34 (8%) had subsequent MI within 3 years. Patients with vessel-related MI and adequate angiograms for 3-dimensional reconstruction (n = 29) were propensity matched to a control group with no MI (n = 29) by using demographic and clinical variables. Coronary lesions were divided into proximal, middle, and distal, along with 5-mm upstream and downstream segments. WSS was calculated for each segment. RESULTS:Median age was 62 years, and 46 (79%) were male. In the marginal Cox model, whereas lower FFR showed a trend (hazard ratio: 0.084; p = 0.064), higher WSSprox (hazard ratio: 1.234; p = 0.002, C-index = 0.65) predicted MI. Adding WSSprox to FFR resulted in a significant increase in global chi-square for predicting MI (p = 0.045), a net reclassification improvement of 0.69 (p = 0.005), and an integrated discrimination index of 0.11 (p = 0.010). CONCLUSIONS:In patients with stable CAD and hemodynamically significant lesions, higher WSS in the proximal segments of atherosclerotic lesions is predictive of MI and has incremental prognostic value over FFR.

journal_name

J Am Coll Cardiol

authors

Kumar A,Thompson EW,Lefieux A,Molony DS,Davis EL,Chand N,Fournier S,Lee HS,Suh J,Sato K,Ko YA,Molloy D,Chandran K,Hosseini H,Gupta S,Milkas A,Gogas B,Chang HJ,Min JK,Fearon WF,Veneziani A,Giddens DP,King SB 3r

doi

10.1016/j.jacc.2018.07.075

subject

Has Abstract

pub_date

2018-10-16 00:00:00

pages

1926-1935

issue

16

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(18)36943-2

journal_volume

72

pub_type

杂志文章,随机对照试验
  • Relation between contractile reserve and positron emission tomographic patterns of perfusion and glucose utilization in chronic ischemic left ventricular dysfunction: implications for identification of myocardial viability.

    abstract:OBJECTIVES:This study sought to determine the incidence and extent of dobutamine-induced contractile reserve in myocardial regions characterized by classical and new positron emission tomographic (PET) patterns in patients with chronic ischemic left ventricular dysfunction. BACKGROUND:PET is considered the most accura...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(97)00373-2

    authors: Mélon PG,de Landsheere CM,Degueldre C,Peters JL,Kulbertus HE,Piérard LA

    更新日期:1997-12-01 00:00:00

  • Optimal left ventricular endocardial pacing sites for cardiac resynchronization therapy in patients with ischemic cardiomyopathy.

    abstract:OBJECTIVES:We sought to investigate the impact of left ventricular (LV) pacing site on mechanical response to cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy (ICM). BACKGROUND:CRT reduces morbidity and mortality in patients with dyssynchronous LV failure; however, variability in respon...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2010.06.014

    authors: Spragg DD,Dong J,Fetics BJ,Helm R,Marine JE,Cheng A,Henrikson CA,Kass DA,Berger RD

    更新日期:2010-08-31 00:00:00

  • Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study.

    abstract:OBJECTIVES:This study sought to determine whether epicardial fat volume predicts coronary events in the general population. BACKGROUND:Epicardial adipose tissue (EAT) is suggested to promote plaque development in the coronary artery tree. METHODS:We quantified EAT volume in participants from the prospective populatio...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2012.11.062

    authors: Mahabadi AA,Berg MH,Lehmann N,Kälsch H,Bauer M,Kara K,Dragano N,Moebus S,Jöckel KH,Erbel R,Möhlenkamp S

    更新日期:2013-04-02 00:00:00

  • Cardiac magnetic resonance predicts outcome in patients with premature ventricular complexes of left bundle branch block morphology.

    abstract:OBJECTIVES:We investigated whether the presence of right ventricular (RV) abnormalities detected by cardiovascular magnetic resonance (CMR) predict adverse outcome in patients presenting with frequent premature ventricular complexes (PVCs) of left bundle branch block (LBBB) morphology. BACKGROUND:CMR is a component of...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2010.03.087

    authors: Aquaro GD,Pingitore A,Strata E,Di Bella G,Molinaro S,Lombardi M

    更新日期:2010-10-05 00:00:00

  • Localization of aortic dissection intimal flap by intraoperative two-dimensional echocardiography.

    abstract::Ascending (type I) aortic dissection carries a high morbidity and mortality. Proper identification of the proximal origin of the dissection and determination of concomitant aortic valve involvement significantly facilitate surgical repair, which may improve survival. In this case, intraoperative two-dimensional echoca...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(85)80324-7

    authors: Goldman ME,Guarino T,Mindich BP

    更新日期:1985-11-01 00:00:00

  • Aneurysmal degeneration of Blalock-Taussig shunts: identification and surgical treatment options.

    abstract::Many Blalock-Taussig shunts (subclavian to pulmonary artery anastomoses) have been created and a significant number are still being done. Two cases of aneurysmal degeneration of a Blalock-Taussig shunt and their management are described. Development of this rare complication may be related to large shunt flow and long...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80188-6

    authors: Scott WC,Zhao HX,Allen M,Kim D,Miller DC

    更新日期:1984-05-01 00:00:00

  • Effects of mibefradil, a novel calcium channel blocking agent with T-type activity, in acute experimental myocardial ischemia: maintenance of ventricular fibrillation threshold without inotropic compromise.

    abstract:OBJECTIVES:We tested whether mibefradil, a selective T-type calcium channel blocking agent, could differentially inhibit experimental ventricular arrhythmogenesis more than contractility during acute regional ischemia and reperfusion compared with that during L-channel blockade by verapamil. BACKGROUND:T-type calcium ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00182-x

    authors: Muller CA,Opie LH,McCarthy J,Hofmann D,Pineda CA,Peisach M

    更新日期:1998-07-01 00:00:00

  • The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease.

    abstract:OBJECTIVES:This study was designed to examine the use of cardiovascular medications and outcomes in patients with heart failure (HF) and renal dysfunction. BACKGROUND:Renal insufficiency is associated with poorer outcomes in patients with HF, but the mechanisms are uncertain. In particular, the degree of therapeutic n...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.06.072

    authors: Ezekowitz J,McAlister FA,Humphries KH,Norris CM,Tonelli M,Ghali WA,Knudtson ML,APPROACH Investigators.

    更新日期:2004-10-19 00:00:00

  • Incidence of asymptomatic intracranial embolic events after pulmonary vein isolation: comparison of different atrial fibrillation ablation technologies in a multicenter study.

    abstract:OBJECTIVES:We compared the safety of different devices by screening for subclinical intracranial embolic events after pulmonary vein isolation with either conventional irrigated radiofrequency (RF) or cryoballoon or multielectrode phased RF pulmonary vein ablation catheter (PVAC). BACKGROUND:New devices specifically d...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2011.04.010

    authors: Herrera Siklódy C,Deneke T,Hocini M,Lehrmann H,Shin DI,Miyazaki S,Henschke S,Fluegel P,Schiebeling-Römer J,Bansmann PM,Bourdias T,Dousset V,Haïssaguerre M,Arentz T

    更新日期:2011-08-09 00:00:00

  • Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9.

    abstract:OBJECTIVES:In this study, our goal was to determine if human resistin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocytes. BACKGROUND:Serum levels of resistin, an adipose tissue-derived adipokine, are increased in human obesity and are positively correlated with atheroscl...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2011.11.064

    authors: Melone M,Wilsie L,Palyha O,Strack A,Rashid S

    更新日期:2012-05-08 00:00:00

  • Percutaneous mitral valvuloplasty in surgical high risk patients.

    abstract::Among 126 consecutive patients undergoing percutaneous mitral valvuloplasty, 34 were judged to be at high risk for surgery on the basis of age greater than 70 years (n = 13), New York Heart Association functional class IV (n = 11), ejection fraction less than or equal to 35% (n = 3), severe pulmonary hypertension (n =...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(10)80098-1

    authors: Lefèvre T,Bonan R,Serra A,Crépeau J,Dyrda I,Petitclerc R,Leclerc Y,Vanderperren O,Waters D

    更新日期:1991-02-01 00:00:00

  • Pregnancy in patients with pre-existing cardiomyopathies.

    abstract::To varying extents, women with pre-existing cardiomyopathies have a limited cardiovascular reserve. The hemodynamic challenges of pregnancy, labor, and delivery pose unique risks to this group of patients, which can result in clinical decompensation with overt heart failure, arrhythmias, and rarely, maternal death. A ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2011.04.014

    authors: Stergiopoulos K,Shiang E,Bench T

    更新日期:2011-07-19 00:00:00

  • Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress.

    abstract:OBJECTIVES:We investigated whether abnormal pteridine metabolism is related to coronary endothelial dysfunction in insulin-resistant subjects. BACKGROUND:Depletion of tetrahydrobiopterin (BH(4)) and elevation of the 7,8-dihydrobiopterin (BH(2)) (activating and inactivating cofactors of nitric oxide synthase [NOS], res...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01659-x

    authors: Shinozaki K,Hirayama A,Nishio Y,Yoshida Y,Ohtani T,Okamura T,Masada M,Kikkawa R,Kodama K,Kashiwagi A

    更新日期:2001-12-01 00:00:00

  • Effect of prior myocardial infarction and extent and location of coronary disease on accuracy of exercise echocardiography.

    abstract::Exercise echocardiography is an emerging technique for the evaluation of patients with suspected coronary artery disease. In this study, rest and immediate postexercise echocardiograms were performed in 123 patients who were stratified on the basis of prior myocardial infarction and the number and location of coronary...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80195-x

    authors: Armstrong WF,O'Donnell J,Ryan T,Feigenbaum H

    更新日期:1987-09-01 00:00:00

  • Interassociation Consensus Statement on Cardiovascular Care of College Student-Athletes.

    abstract::Cardiovascular evaluation and care of college student-athletes is gaining increasing attention from both the public and medical communities. Emerging strategies include screening of the general athlete population, recommendations of permissible levels of participation by athletes with identified cardiovascular conditi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.jacc.2016.03.527

    authors: Hainline B,Drezner JA,Baggish A,Harmon KG,Emery MS,Myerburg RJ,Sanchez E,Molossi S,Parsons JT,Thompson PD

    更新日期:2016-06-28 00:00:00

  • Which white blood cell subtypes predict increased cardiovascular risk?

    abstract:OBJECTIVES:We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI). BACKGROUND:An elevated WBC count has been associated with cardiovascular risk, but which leukocyte subtypes carry this risk is uncertain. METHODS:Consecutive...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2005.02.054

    authors: Horne BD,Anderson JL,John JM,Weaver A,Bair TL,Jensen KR,Renlund DG,Muhlestein JB,Intermountain Heart Collaborative Study Group.

    更新日期:2005-05-17 00:00:00

  • Impact of cardiac resynchronization therapy using hemodynamically optimized pacing on left ventricular remodeling in patients with congestive heart failure and ventricular conduction disturbances.

    abstract:OBJECTIVES:We sought to investigate the impact of six months of cardiac resynchronization therapy (CRT) on echocardiographic variables of left ventricular (LV) function. BACKGROUND:Cardiac resynchronization therapy has recently been introduced as a new therapeutic modality in patients with advanced heart failure (HF) ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0735-1097(01)01637-0

    authors: Stellbrink C,Breithardt OA,Franke A,Sack S,Bakker P,Auricchio A,Pochet T,Salo R,Kramer A,Spinelli J,PATH-CHF (PAcing THerapies in Congestive Heart Failure) Investigators; CPI Guidant Congestive Heart Failure Research Group.

    更新日期:2001-12-01 00:00:00

  • Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.

    abstract:OBJECTIVES:We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs). BACKGROUND:Endothelial progenitor cells play a pivotal role in regeneration of injured endothelium, thereby limiting the formation of atherosclerotic lesions. Reduced numbe...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2005.04.066

    authors: Thum T,Tsikas D,Stein S,Schultheiss M,Eigenthaler M,Anker SD,Poole-Wilson PA,Ertl G,Bauersachs J

    更新日期:2005-11-01 00:00:00

  • Long-term outcomes after stenting of bifurcation lesions with the "crush" technique: predictors of an adverse outcome.

    abstract:OBJECTIVES:The purpose of this study was to evaluate predictors of an adverse outcome after "crush" bifurcation stenting. BACKGROUND:The "crush" technique is a recently introduced strategy with limited data regarding long-term outcomes. METHODS:We identified 231 consecutive patients treated with drug-eluting stent im...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2005.11.083

    authors: Hoye A,Iakovou I,Ge L,van Mieghem CA,Ong AT,Cosgrave J,Sangiorgi GM,Airoldi F,Montorfano M,Michev I,Chieffo A,Carlino M,Corvaja N,Aoki J,Rodriguez Granillo GA,Valgimigli M,Sianos G,van der Giessen WJ,de Feyter PJ,va

    更新日期:2006-05-16 00:00:00

  • Double sequential external shocks for refractory ventricular fibrillation.

    abstract:OBJECTIVES:A technique for terminating refractory ventricular fibrillation is described. BACKGROUND:Refractory ventricular fibrillation can occur in up to 0.1% of electrophysiologic studies. Animal studies have shown that rapid sequential shocks may reduce ventricular fibrillation threshold. METHODS:Five patients of ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90602-5

    authors: Hoch DH,Batsford WP,Greenberg SM,McPherson CM,Rosenfeld LE,Marieb M,Levine JH

    更新日期:1994-04-01 00:00:00

  • Myocardial viability in chronic ischemic heart disease: comparison of contrast-enhanced magnetic resonance imaging with (18)F-fluorodeoxyglucose positron emission tomography.

    abstract:OBJECTIVES:We sought to compare contrast-enhanced magnetic resonance imaging (ceMRI) with nuclear metabolic imaging for the assessment of myocardial viability in patients with chronic ischemic heart disease and left ventricular (LV) dysfunction. BACKGROUND:Contrast-enhanced MRI has been shown to identify scar tissue i...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(03)00158-x

    authors: Kühl HP,Beek AM,van der Weerdt AP,Hofman MB,Visser CA,Lammertsma AA,Heussen N,Visser FC,van Rossum AC

    更新日期:2003-04-16 00:00:00

  • Right coronary artery-pulmonary artery arteriovenous fistula secondary to open heart surgery.

    abstract::A patient is described who underwent atrial septal defect repair at age 12 and presented 16 years later with angina. Coronary angiography revealed a right coronary artery to pulmonary artery fistula that had developed at the site of the previous thoracotomy. This is the first report of an acquired fistula of this type...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(85)80509-x

    authors: Rothschild AH,Adatepe MH,Magovern GJ,Rothschild MA,Joyner CR

    更新日期:1985-10-01 00:00:00

  • A prospective case-control study of antibodies to coxsackie B virus in idiopathic dilated cardiomyopathy.

    abstract:OBJECTIVES:This study was conducted to determine the frequency and significance of Coxsackie B virus-specific immunoglobulin-M (IgM) in patients with idiopathic dilated cardiomyopathy and compare them with the frequency in both unmatched and matched control subjects. BACKGROUND:The principal evidence supporting a path...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90742-0

    authors: Keeling PJ,Lukaszyk A,Poloniecki J,Caforio AL,Davies MJ,Booth JC,McKenna WJ

    更新日期:1994-03-01 00:00:00

  • Cell-mediated cytotoxicity in hearts with dilated cardiomyopathy: correlation with interstitial fibrosis and foci of activated T lymphocytes.

    abstract:OBJECTIVES:The purpose of this study was to investigate the expression of perforin and T-cell intracellular antigen-1, two crucial components of lymphocyte-mediated cytotoxicity, in endomyocardial biopsies from patients with idiopathic dilated cardiomyopathy. BACKGROUND:Previous reports have demonstrated the presence ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(96)00475-5

    authors: Badorff C,Noutsias M,Kühl U,Schultheiss HP

    更新日期:1997-02-01 00:00:00

  • Cholesterol-lowering interventions and stroke: insights from a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVES:This meta-analysis was performed to determine the effects of various cholesterol-lowering treatments on the risk of stroke and its relationship with the extent of cholesterol lowering. BACKGROUND:Statins reduce the incidence of stroke, and it has been proposed that such effect is independent of cholesterol ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jacc.2009.07.062

    authors: De Caterina R,Scarano M,Marfisi R,Lucisano G,Palma F,Tatasciore A,Marchioli R

    更新日期:2010-01-19 00:00:00

  • Long-term outcome in patients with Marfan syndrome: is aortic dissection the only cause of sudden death?

    abstract:OBJECTIVES:We sought to assess outcomes in a series of young patients with Marfan syndrome and to define the prevalence of ventricular arrhythmias in this patient population. BACKGROUND:While sudden death is a well-recognized outcome in Marfan syndrome, ventricular arrhythmias are not well described. METHODS:Patients...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(02)02699-2

    authors: Yetman AT,Bornemeier RA,McCrindle BW

    更新日期:2003-01-15 00:00:00

  • Effects of left ventricular asynchrony on time constant and extrapolated pressure of left ventricular pressure decay in coronary artery disease.

    abstract::To elucidate the effects of ventricular asynchrony with or without myocardial ischemia on the time constant of left ventricular pressure decay and asymptote, that is, the level to which pressure would decrease if isovolumic pressure decrease continued infinitely, left ventriculography and pressure measurements were in...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(85)80118-2

    authors: Takeuchi M,Fujitani K,Kurogane K,Bai HT,Toda C,Yamasaki T,Fukuzaki H

    更新日期:1985-09-01 00:00:00

  • Human arterial surface fluorescence: atherosclerotic plaque identification and effects of laser atheroma ablation.

    abstract::In vivo plaque recognition may be important for safe and precise intra-arterial atheroma ablation during laser coronary angioplasty. This study examined the feasibility and sensitivity of utilizing quantitative fluorescence spectroscopy and video-enhanced fluorescence imaging for plaque identification in atherosclerot...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(88)90361-0

    authors: Leon MB,Lu DY,Prevosti LG,Macy WW Jr,Smith PD,Granovsky M,Bonner RF,Balaban RS

    更新日期:1988-07-01 00:00:00

  • Echo-Doppler mitral flow monitoring: an operative tool to evaluate day-to-day tolerance to and effectiveness of beta-adrenergic blocking agent therapy in patients with chronic heart failure.

    abstract:OBJECTIVES:The goals of this study were: 1) to assess the predictive value of baseline mitral flow pattern (MFP) and its changes after loading manipulations as regards tolerance to and effectiveness of beta-adrenergic blocking agent treatment in patients with chronic heart failure (CHF); and 2) to analyze the prognosti...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01609-6

    authors: Capomolla S,Pinna GD,Febo O,Caporotondi A,Guazzotti G,La Rovere MT,Gnemmi M,Mortara A,Maestri R,Cobelli F

    更新日期:2001-11-15 00:00:00

  • Intravascular ultrasound imaging of saphenous vein grafts in vitro: comparison with histologic and quantitative angiographic findings.

    abstract::The ubiquity of coronary artery disease and the resultant widespread use of saphenous veins for coronary artery bypass surgery has stimulated considerable interest in the morphologic and pathophysiologic alterations these vessels undergo after implantation. This study was undertaken to determine the ability of intrava...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(92)90514-n

    authors: Willard JE,Netto D,Demian SE,Haagen DR,Brickner ME,Eichhorn EJ,Grayburn PA

    更新日期:1992-03-15 00:00:00