Abstract:
:Cardiac electrophysiologic alterations were evaluated 1 to 8 months after partial supracoronary aortic constriction in cats. This procedure induced left ventricular systolic hypertension and hypertrophy with marked connective tissue infiltration. In situ, premature ventricular complexes were observed during or after vagal slowing of sinus rate in 8 (26%) of the 31 experimental animals, while an additional 3 of the 31 developed ventricular fibrillation. No arrhythmias were recorded in 31 normal or 7 sham-operated cats. In vitro, 29% of the left ventricular preparations from cats with pressure overload and 5% from control cats showed spontaneous ectopic activity. During stimulation at cycle lengths of 800 to 1,000 ms, multiple site impalements of subendocardial muscle cells within fibrotic regions revealed heterogeneous electrical abnormalities. These included short action potential duration, low amplitude action potentials generated from low resting potentials, split upstrokes and electrically silent areas. Impalements in nonfibrotic areas of the left ventricle showed prolongation of muscle action potential duration. Long-term disturbances in cellular electrophysiologic properties may favor the development of arrhythmias and thereby contribute to sudden cardiac death in left ventricular hypertension and hypertrophy.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Cameron JS,Myerburg RJ,Wong SS,Gaide MS,Epstein K,Alvarez TR,Gelband H,Guse PA,Bassett ALdoi
10.1016/s0735-1097(83)80275-7subject
Has Abstractpub_date
1983-09-01 00:00:00pages
481-7issue
3eissn
0735-1097issn
1558-3597pii
S0735-1097(83)80275-7journal_volume
2pub_type
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