Abstract:
:MDL 17,043, an inotropic and vasodilator drug, is believed to have beneficial effects in patients with heart failure. Its short- and long-term hemodynamic and cardiopulmonary effects were studied in 10 patients with New York Heart Association functional class III heart failure who were maintained on digitalis and diuretic drugs. Hemodynamics at baseline study and after 24 hours of oral therapy (four doses of 6 mg/kg) showed increased cardiac output (3.9 +/- 0.7 to 6.1 +/- 1.1 liters/min, p less than 0.05), increased stroke volume (42 +/- 12 to 60 +/- 15 ml, p less than 0.05), decreased systemic vascular resistance (1,564 +/- 326 to 1,009 +/- 296 dynes X s X cm-5, p less than 0.05) but no change in pulmonary capillary wedge pressure (31 +/- 6 to 25 +/- 13 mm Hg, p = NS). Only systemic vascular resistance and arteriovenous oxygen difference were significantly decreased during exercise. When restudied after 5 weeks of therapy, neither cardiac output nor stroke volume showed a sustained increase at rest or during exercise, and effects on systemic vascular resistance and arteriovenous oxygen difference were not sustained at exercise (p = NS). Peak oxygen uptake during exercise was 8.1 +/- 2.5 ml/kg per min at baseline and was not significantly increased either acutely (9.2 +/- 2.4 ml/kg per min, p = NS) or chronically (8.9 +/- 2.2 ml/kg per min, p = NS). Problems of increased ventricular arrhythmias and diarrhea were noted after therapy was begun.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Rubin SA,Tabak Ldoi
10.1016/s0735-1097(85)80359-4subject
Has Abstractpub_date
1985-06-01 00:00:00pages
1422-7issue
6eissn
0735-1097issn
1558-3597pii
S0735-1097(85)80359-4journal_volume
5pub_type
临床试验,杂志文章abstract:OBJECTIVES:The goal of this study was to determine the magnitude and mechanisms of hemodynamic improvement of an automated, load-distributing band device (AutoPulse, Revivant Corp., Sunnyvale, California) compared with conventional cardiopulmonary resuscitation (C-CPR). BACKGROUND:Improved blood flow during cardiopulm...
journal_title:Journal of the American College of Cardiology
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更新日期:2004-12-07 00:00:00
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更新日期:2004-04-07 00:00:00
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doi:10.1016/j.jacc.2015.10.093
更新日期:2016-02-09 00:00:00
abstract:OBJECTIVE:To determine whether electron beam computed tomography (CT) adds to conventional risk factor assessment in the prediction of angiographic coronary artery disease. BACKGROUND:Electron beam CT scanning can be used to predict the severity of coronary atherosclerosis, but whether it does so independently of conv...
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doi:10.1016/s0735-1097(98)00299-x
更新日期:1998-09-01 00:00:00
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更新日期:2011-11-29 00:00:00
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更新日期:1986-12-01 00:00:00
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更新日期:1987-02-01 00:00:00
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更新日期:2018-01-16 00:00:00
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更新日期:2013-09-10 00:00:00
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更新日期:1999-10-01 00:00:00
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更新日期:2008-06-17 00:00:00
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doi:10.1016/j.jacc.2014.02.584
更新日期:2014-06-03 00:00:00
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更新日期:1999-04-01 00:00:00
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更新日期:2015-06-09 00:00:00
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更新日期:2018-08-28 00:00:00
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更新日期:2007-10-02 00:00:00
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更新日期:2007-05-22 00:00:00
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更新日期:1995-04-01 00:00:00