当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation.

The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation.

Abstract：

OBJECTIVES:The aim of this multicenter study was to evaluate the safety of discontinuing oral anticoagulation therapy (OAT) after apparently successful pulmonary vein isolation. BACKGROUND:Atrial fibrillation (AF) is associated with an increased risk of thromboembolic events (TE) and often requires OAT. Pulmonary vein isolation is considered an effective treatment for AF. METHODS:We studied 3,355 patients, of whom 2,692 (79% male, mean age 57 +/- 11 years) discontinued OAT 3 to 6 months after ablation (Off-OAT group) and 663 (70% male, mean age 59 +/- 11 years) remained on OAT after this period (On-OAT group). CHADS(2) (congestive heart failure, hypertension, age [75 years and older], diabetes mellitus, and a history of stroke or transient ischemic attack) risk scores of 1 and > or =2 were recorded in 723 (27%) and 347 (13%) Off-OAT group patients and in 261 (39%) and 247 (37%) On-OAT group patients, respectively. RESULTS:During follow-up (mean 28 +/- 13 months vs. 24 +/- 15 months), 2 (0.07%) Off-OAT group patients and 3 (0.45%) On-OAT group patients had an ischemic stroke (p = 0.06). No other thromboembolic events occurred. No Off-OAT group patient with a CHADS(2) risk score of > or =2 had an ischemic stroke. A major hemorrhage was observed in 1 (0.04%) Off-OAT group patient and 13 (2%) On-OAT group patients (p < 0.0001). CONCLUSIONS:In this nonrandomized study, the risk-benefit ratio favored the suspension of OAT after successful AF ablation even in patients at moderate-high risk of TE. This conclusion needs to be confirmed by future large randomized trials.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Themistoclakis S,Corrado A,Marchlinski FE,Jais P,Zado E,Rossillo A,Di Biase L,Schweikert RA,Saliba WI,Horton R,Mohanty P,Patel D,Burkhardt DJ,Wazni OM,Bonso A,Callans DJ,Haissaguerre M,Raviele A,Natale A

doi

10.1016/j.jacc.2009.11.039

subject

Has Abstract

pub_date

2010-02-23 00:00:00

pages

735-43

issue

8

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(09)04080-7

journal_volume

55

pub_type

临床试验,杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • "Ischemia at a distance" during intermittent coronary artery occlusion: a coronary anatomic explanation.

    abstract：:The mechanism of electrocardiographic ST segment changes during acute coronary occlusion was evaluated in 28 consecutive patients with single vessel coronary artery disease undergoing coronary angioplasty. Patients were continuously monitored with a six lead electrocardiogram. Twenty-three patients showed ST changes i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80250-3

    authors： Brymer JF,Khaja F,Marzilli M,Goldstein S

    更新日期：1985-07-01 00:00:00

  • Pulmonary atresia in prenatal life.

    abstract：:Seven cases of pulmonary atresia with intact ventricular septum were detected in prenatal life. In two of these cases, there was a small hypertrophied right ventricle of the type commonly seen postnatally. In the remaining five cases, the right atrium and right ventricle were grossly dilated to a degree that caused lu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80392-8

    authors： Allan LD,Crawford DC,Tynan MJ

    更新日期：1986-11-01 00:00:00

  • Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study.

    abstract：OBJECTIVES:This study aimed to determine the diagnostic and prognostic value of urinary biomarkers of intrinsic acute kidney injury (AKI) when patients were triaged in the emergency department. BACKGROUND:Intrinsic AKI is associated with nephron injury and results in poor clinical outcomes. Several urinary biomarkers ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2011.10.854

    authors： Nickolas TL,Schmidt-Ott KM,Canetta P,Forster C,Singer E,Sise M,Elger A,Maarouf O,Sola-Del Valle DA,O'Rourke M,Sherman E,Lee P,Geara A,Imus P,Guddati A,Polland A,Rahman W,Elitok S,Malik N,Giglio J,El-Sayegh S,Dev

    更新日期：2012-01-17 00:00:00

  • Ultrastructural findings in endomyocardial biopsy of patients with Kearns-Sayre syndrome.

    abstract：:Kearns-Sayre syndrome is clinically defined by progressive external ophthalmoplegia, atypical retinitis pigmentosa and the potential occurrence of complete atrioventricular (AV) block. Right septal endomyocardial biopsy specimens from nine patients (four men and five women with a mean [+/- SD] [corrected] age of 36.3 ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(88)80020-2

    authors： Schwartzkopff B,Frenzel H,Breithardt G,Deckert M,Lösse B,Toyka KV,Borggrefe M,Hort W

    更新日期：1988-12-01 00:00:00

  • Local treatment with antithrombotic drugs can prevent thrombus formation: an angioscopic and angiographic study.

    abstract：OBJECTIVES:This study was designed to evaluate the efficacy of local versus systemic treatment of thrombosis with various antithrombotic drugs. BACKGROUND:Local use of low dose antithrombotic drugs has been proposed as being effective and safe. METHODS:Heparin (30 U/kg), an antithrombin agent (argatroban, 0.05 mg/kg ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00324-X

    authors： Tomaru T,Nakamura F,Fujimori Y,Omata M,Kawai S,Okada R,Murata Y,Uchida Y

    更新日期：1995-11-01 00:00:00

  • Isolated systolic hypertension in young and middle-aged adults and 31-year risk for cardiovascular mortality: the Chicago Heart Association Detection Project in Industry study.

    abstract：BACKGROUND:Isolated systolic hypertension (ISH), defined as systolic blood pressure (SBP) ≥140 mm Hg and diastolic blood pressure (DBP) <90 mm Hg, in younger and middle-aged adults is increasing in prevalence. OBJECTIVE:The aim of this study was to assess the risk for cardiovascular disease (CVD) with ISH in younger a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.10.060

    authors： Yano Y,Stamler J,Garside DB,Daviglus ML,Franklin SS,Carnethon MR,Liu K,Greenland P,Lloyd-Jones DM

    更新日期：2015-02-03 00:00:00

  • An epidemic of dyssynchrony: but what does it mean?

    abstract：:Cardiac resynchronization therapy (CRT) is used to treat a subset of heart failure patients with discoordinate wall motion. Defining appropriate patients is important, and, although electrical delay (wide QRS) is commonly used, recent data show that measures of mechanical dyssynchrony improve the sensitivity and speci...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2007.09.027

    authors： Kass DA

    更新日期：2008-01-01 00:00:00

  • Rupture of a left ventricular papillary muscle during acute myocardial infarction: analysis of 22 necropsy patients.

    abstract：:Certain clinical and cardiac morphologic findings are described in 22 patients, aged 45 to 80 years (mean 64) (15 men [68%]), in whom rupture of a papillary muscle occurred during acute myocardial infarction. In most, the acute infarction associated with papillary muscle rupture was a first coronary event (only 18% ha...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80182-6

    authors： Barbour DJ,Roberts WC

    更新日期：1986-09-01 00:00:00

  • A randomized assessment of the incremental role of ablation of complex fractionated atrial electrograms after antral pulmonary vein isolation for long-lasting persistent atrial fibrillation.

    abstract：OBJECTIVES:This study sought to determine whether ablation of complex fractionated atrial electrograms (CFAEs) after antral pulmonary vein isolation (APVI) further improves the clinical outcome of APVI in patients with long-lasting persistent atrial fibrillation (AF). BACKGROUND:Ablation of CFAEs has been reported to ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jacc.2008.10.054

    authors： Oral H,Chugh A,Yoshida K,Sarrazin JF,Kuhne M,Crawford T,Chalfoun N,Wells D,Boonyapisit W,Veerareddy S,Billakanty S,Wong WS,Good E,Jongnarangsin K,Pelosi F Jr,Bogun F,Morady F

    更新日期：2009-03-03 00:00:00

  • Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization.

    abstract：BACKGROUND:Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. OBJECTIVES:This study sought to determine if treatment with sacubitril/valsartan (LCZ696) reduces rates of hospital readmission at 30-days following HF hospitalization compared with ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2016.04.047

    authors： Desai AS,Claggett BL,Packer M,Zile MR,Rouleau JL,Swedberg K,Shi V,Lefkowitz M,Starling R,Teerlink J,McMurray JJV,Solomon SD,PARADIGM-HF Investigators.

    更新日期：2016-07-19 00:00:00

  • Therapy for ST-segment elevation myocardial infarction patients who present late or are ineligible for reperfusion therapy.

    abstract：:Despite the wide contemporary availability of pharmacological and mechanical means of reperfusion, a very significant proportion of ST-segment elevation myocardial infarction (STEMI) patients are still not offered any reperfusion therapy, and some of them are considered "ineligible for reperfusion." Spontaneous reperf...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2009.11.087

    authors： Cohen M,Boiangiu C,Abidi M

    更新日期：2010-05-04 00:00:00

  • Impaired response of left ventricular relaxation to exercise-induced adrenergic stimulation in patients with hypertrophic cardiomyopathy.

    abstract：OBJECTIVES:We investigated the effect of adrenergic stimulation on left ventricular relaxation in patients with hypertrophic cardiomyopathy. BACKGROUND:Exercise-induced decreases in acceleration of left ventricular relaxation have been observed in patients with hypertrophic cardiomyopathy. However, data on sequential ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/S0735-1097(96)00378-6

    authors： Izawa H,Yokota M,Nagata K,Iwase M,Sobue T

    更新日期：1996-12-01 00:00:00

  • Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction.

    abstract：BACKGROUND:In addition to scalability, human embryonic stem cells (hESCs) have the unique advantage of allowing their directed differentiation toward lineage-specific cells. OBJECTIVES:This study tested the feasibility of leveraging the properties of hESCs to generate clinical-grade cardiovascular progenitor cells and...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jacc.2017.11.047

    authors： Menasché P,Vanneaux V,Hagège A,Bel A,Cholley B,Parouchev A,Cacciapuoti I,Al-Daccak R,Benhamouda N,Blons H,Agbulut O,Tosca L,Trouvin JH,Fabreguettes JR,Bellamy V,Charron D,Tartour E,Tachdjian G,Desnos M,Larghero J

    更新日期：2018-01-30 00:00:00

  • Drug-eluting stents in the treatment of intermediate lesions: pooled analysis from four randomized trials.

    abstract：OBJECTIVES:To address the safety and efficacy of drug-eluting stents (DES) in the treatment of intermediate lesions, we performed a pooled analysis of four randomized DES versus bare-metal stent (BMS) trials and assessed outcomes among patients with intermediate lesions. BACKGROUND:Before the introduction of DES, inte...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jacc.2006.01.068

    authors： Moses JW,Stone GW,Nikolsky E,Mintz GS,Dangas G,Grube E,Ellis SG,Lansky AJ,Weisz G,Fahy M,Na Y,Russell ME,Donohoe D,Leon MB,Mehran R

    更新日期：2006-06-06 00:00:00

  • Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness.

    abstract：OBJECTIVES:The purpose of this study was to use cardiac magnetic resonance (CMR) imaging and invasive left ventricular (LV) pressure-volume (PV) measurements to explore the relationship between diffuse myocardial fibrosis and indexes of diastolic performance in a cohort of cardiac transplant recipients. BACKGROUND:The...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2013.10.084

    authors： Ellims AH,Shaw JA,Stub D,Iles LM,Hare JL,Slavin GS,Kaye DM,Taylor AJ

    更新日期：2014-03-25 00:00:00

  • Isolated left main coronary ostial stenosis in Oriental people: operative, histopathologic and clinical findings in six patients.

    abstract：OBJECTIVES:This study was performed to determine whether there are differences in the operative, histopathologic, angiographic and clinical findings of isolated ostial stenosis between Oriental and western patients. BACKGROUND:Angiographic, clinical and histologic findings in isolated ostial stenosis have been reporte...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90677-s

    authors： Koh KK,Hwang HK,Kim PG,Lee SH,Cho SK,Kim SS,Han JJ,Lee YT,Park PW,Yoon DH

    更新日期：1993-02-01 00:00:00

  • Sustained ventricular tachyarrhythmias during the early postinfarction period: electrophysiologic findings and prognosis for survival.

    abstract：:Forty patients with sustained tachycardia occurring 3 to 65 days after myocardial infarction underwent programmed ventricular stimulation within 3 months of the infarction. Patients were characterized clinically by a complicated initial 48 hours of hospitalization for their acute infarction (85% of study group). The d...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80159-4

    authors： Marchlinski FE,Waxman HL,Buxton AE,Josephson ME

    更新日期：1983-08-01 00:00:00

  • Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults.

    abstract：BACKGROUND:Previous studies have revealed inconsistent findings regarding the association of light to moderate alcohol consumption with cardiovascular disease (CVD) and cancer mortality. OBJECTIVES:The aim of this study was to examine the association between alcohol consumption and risk of mortality from all causes, c...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2017.06.054

    authors： Xi B,Veeranki SP,Zhao M,Ma C,Yan Y,Mi J

    更新日期：2017-08-22 00:00:00

  • Effect of a passive endocardial electrode on defibrillation efficacy of a nonthoracotomy lead system.

    abstract：OBJECTIVES:We investigated the impact of an inactive endocardial lead on the 50% effective dose (ED50%) for successful ventricular defibrillation. BACKGROUND:The presence of abandoned epicardial mesh patch electrodes detrimentally affects the defibrillation efficacy of an endocardial lead system. It is not known wheth...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(96)00573-6

    authors： Fotuhi PC,Kenknight BH,Melnick SB,Smith WM,Baumann GF,Ideker RE

    更新日期：1997-03-15 00:00:00

  • Quality and Equitable Health Care Gaps for Women: Attributions to Sex Differences in Cardiovascular Medicine.

    abstract：:The present review synthesizes evidence and discusses issues related to health care quality and equity for women, including minority population subgroups. The principle of "sameness" or women and men receiving equitable, high-quality care is a near-term target, but optimal population health cannot be achieved without ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2017.05.051

    authors： Shaw LJ,Pepine CJ,Xie J,Mehta PK,Morris AA,Dickert NW,Ferdinand KC,Gulati M,Reynolds H,Hayes SN,Itchhaporia D,Mieres JH,Ofili E,Wenger NK,Bairey Merz CN

    更新日期：2017-07-18 00:00:00

  • Ventricular arrhythmias in the absence of structural heart disease.

    abstract：:Ventricular arrhythmia (VA) in structurally normal hearts can be broadly considered under non-life-threatening monomorphic and life-threatening polymorphic rhythms. Monomorphic VA is classified on the basis of site of origin in the heart, and the most common areas are the ventricular outflow tracts and left ventricula...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2012.01.036

    authors： Prystowsky EN,Padanilam BJ,Joshi S,Fogel RI

    更新日期：2012-05-15 00:00:00

  • Comparison of frequency and time domain analysis of the signal-averaged electrocardiogram in patients with ventricular tachycardia and coronary artery disease: methodologic validation and clinical relevance.

    abstract：:Frequency analysis with fast Fourier transform and time domain analysis after signal averaging of the electrocardiogram (ECG) have given contradictory results in patients with sustained ventricular tachycardia after myocardial infarction. Therefore, the same orthogonal ECGs were analyzed in the frequency domain (Black...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(88)90368-3

    authors： Haberl R,Jilge G,Pulter R,Steinbeck G

    更新日期：1988-07-01 00:00:00

  • The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram: a population-based study of four decades.

    abstract：OBJECTIVES:We sought to demonstrate the prevalence, incidence and prognostic value of the Brugada-type electrocardiogram (ECG) in a general population. BACKGROUND:The Brugada syndrome is characterized by evidence of right bundle branch block and ST segment elevation in the right precordial leads, as well as sudden dea...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01421-8

    authors： Matsuo K,Akahoshi M,Nakashima E,Suyama A,Seto S,Hayano M,Yano K

    更新日期：2001-09-01 00:00:00

  • Age as a risk factor for stroke in atrial fibrillation patients: implications for thromboprophylaxis.

    abstract：:The prevalence of atrial fibrillation (AF) is related to age and is projected to rise exponentially as the population ages and the prevalence of cardiovascular risk factors increases. The risk of ischemic stroke is significantly increased in AF patients, and there is evidence of a graded increased risk of stroke assoc...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2010.05.028

    authors： Marinigh R,Lip GY,Fiotti N,Giansante C,Lane DA

    更新日期：2010-09-07 00:00:00

  • Hemodynamic effects of nifedipine in primary pulmonary hypertension.

    abstract：:Progressive dyspnea and syncope occurred in a young woman with primary pulmonary hypertension despite therapy with hydralazine. Abnormal pulmonary artery reactivity was documented by an additional increase in pulmonary artery pressure and pulmonary vascular resistance during exercise and after an episode of hydralazin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80389-1

    authors： Douglas JS Jr

    更新日期：1983-07-01 00:00:00

  • Potentiation of Doxorubicin cardiotoxicity by iron loading in a rodent model.

    abstract：OBJECTIVES:The role of iron toward doxorubicin (DOX) cardiotoxicity was studied using a rodent model of dietary carbonyl iron loading. BACKGROUND:Doxorubicin, a commonly used anticancer drug, is known to cause serious and potentially life-threatening cardiotoxicity. Doxorubicin cardiotoxicity is thought to be mediated...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.02.060

    authors： Panjrath GS,Patel V,Valdiviezo CI,Narula N,Narula J,Jain D

    更新日期：2007-06-26 00:00:00

  • Current perspectives on coronary chronic total occlusions: the Canadian Multicenter Chronic Total Occlusions Registry.

    abstract：OBJECTIVES:The purpose of this study was to determine the prevalence, clinical characteristics, and management of coronary chronic total occlusions (CTOs) in current practice. BACKGROUND:There is little evidence in contemporary literature concerning the prevalence, clinical characteristics, and treatment decisions reg...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2011.12.007

    authors： Fefer P,Knudtson ML,Cheema AN,Galbraith PD,Osherov AB,Yalonetsky S,Gannot S,Samuel M,Weisbrod M,Bierstone D,Sparkes JD,Wright GA,Strauss BH

    更新日期：2012-03-13 00:00:00

  • Electroanatomic mapping of arrhythmogenic right ventricular dysplasia.

    abstract：OBJECTIVES:We tested the hypothesis that spatial association of low-amplitude intracardiac electrograms can identify the presence, location and extent of dysplastic regions in arrhythmogenic right ventricular dysplasia (ARVD). BACKGROUND:Arrhythmogenic right ventricular dysplasia is a right ventricular (RV) cardiomyop...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01625-4

    authors： Boulos M,Lashevsky I,Reisner S,Gepstein L

    更新日期：2001-12-01 00:00:00

  • Morphologic comparison of patients with mitral valve prolapse who died suddenly with patients who died from severe valvular dysfunction or other conditions.

    abstract：:Clinical and necropsy findings are described in 56 patients with mitral valve prolapse: 15 patients, aged 16 to 69 years (mean 39), died suddenly and mitral valve prolapse was the only cardiac condition found at necropsy (hereafter called isolated mitral valve prolapse); the remaining 41 patients had other conditions ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90875-a

    authors： Dollar AL,Roberts WC

    更新日期：1991-03-15 00:00:00

  • Mechanism of prevention of sudden death by nadolol: differential actions on arrhythmia triggers and substrate after myocardial infarction in the dog.

    abstract：:Electrocardiographic monitoring and provocative ventricular pacing were used to evaluate control and nadolol treatment groups 6 to 24 hours after left anterior descending coronary artery ligation in the dog. During the 6 to 24 hour period, the control group (n = 20) developed ventricular triplets at rates exceeding 27...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80309-6

    authors： Patterson E,Scherlag BJ,Lazzara R

    更新日期：1986-12-01 00:00:00