Hemodynamic effects of nifedipine in primary pulmonary hypertension.

Abstract:

:Progressive dyspnea and syncope occurred in a young woman with primary pulmonary hypertension despite therapy with hydralazine. Abnormal pulmonary artery reactivity was documented by an additional increase in pulmonary artery pressure and pulmonary vascular resistance during exercise and after an episode of hydralazine-induced hypotension. Nifedipine reduced rest and exercise pulmonary artery pressure, pulmonary vascular resistance and right ventricular stroke work, and increased cardiac output and markedly improved exercise capacity. Reevaluation after 6 months showed persistence of the favorable hemodynamic and clinical effects. Vasodilator therapy, potentially hazardous because of effects on systemic vascular resistance, can be evaluated safely only with hemodynamic monitoring. Nifedipine may be a useful drug in selected patients with primary pulmonary hypertension.

journal_name

J Am Coll Cardiol

authors

Douglas JS Jr

doi

10.1016/s0735-1097(83)80389-1

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

174-9

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(83)80389-1

journal_volume

2

pub_type

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