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Diffuse myocardial fibrosis evaluated by post-contrast t1 mapping correlates with left ventricular stiffness.

Abstract：

OBJECTIVES:The purpose of this study was to use cardiac magnetic resonance (CMR) imaging and invasive left ventricular (LV) pressure-volume (PV) measurements to explore the relationship between diffuse myocardial fibrosis and indexes of diastolic performance in a cohort of cardiac transplant recipients. BACKGROUND:The precise mechanism of LV diastolic dysfunction in the presence of myocardial fibrosis has not previously been established. METHODS:We performed CMR with T1 mapping and obtained invasive LV PV measurements via a conductance catheter in 20 cardiac transplant recipients at the time of clinically-indicated coronary angiography. RESULTS:Both post-contrast myocardial T1 time and extracellular volume fraction correlated with β, the load-independent passive LV stiffness constant (r = -0.71, p = 0.001, and r = 0.58, p = 0.04, respectively). After multivariate analysis, post-contrast myocardial T1 time remained the only independent predictor of β. No significant associations were observed between myocardial T1 time and τ, the active LV relaxation constant, or other load-dependent parameters of diastolic function. CONCLUSIONS:Diffuse myocardial fibrosis, assessed by post-contrast myocardial T1 time, correlates with invasively-demonstrated LV stiffness in cardiac transplant recipients. In patients with increased diffuse myocardial fibrosis, abnormal passive ventricular stiffness is therefore likely to be a major contributor to diastolic dysfunction.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Ellims AH,Shaw JA,Stub D,Iles LM,Hare JL,Slavin GS,Kaye DM,Taylor AJ

doi

10.1016/j.jacc.2013.10.084

subject

Has Abstract

pub_date

2014-03-25 00:00:00

pages

1112-8

issue

11

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(13)06537-6

journal_volume

63

pub_type

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