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Inflammation in Heart Failure: JACC State-of-the-Art Review.

Abstract：

:It has long been observed that heart failure (HF) is associated with measures of systemic inflammation. In recent years, there have been significant advancements in our understanding of how inflammation contributes to the pathogenesis and progression of HF. However, although numerous studies have validated the association between measures of inflammation and HF severity and prognosis, clinical trials of anti-inflammatory therapies have proven mostly unsuccessful. On this backdrop emerges the yet unmet goal of targeting precise phenotypes within the syndrome of HF; if such precise definitions can be realized, and with better understanding of the roles played by specific inflammatory mediators, the expectation is that targeted anti-inflammatory therapies may improve prognosis in patients whose HF is driven by inflammatory pathobiology. Here, the authors describe mechanistic links between inflammation and HF, discuss traditional and novel inflammatory biomarkers, and summarize the latest evidence from clinical trials of anti-inflammatory therapies.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Murphy SP,Kakkar R,McCarthy CP,Januzzi JL Jr

doi

10.1016/j.jacc.2020.01.014

subject

Has Abstract

pub_date

2020-03-24 00:00:00

pages

1324-1340

issue

11

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(20)30257-6

journal_volume

75

pub_type

杂志文章,评审

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