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Coexistent pulmonary and portal hypertension: morphologic and clinical features.

Abstract：

:Patients with portal hypertension of varying etiology may develop pulmonary artery hypertension. In the present autopsy study, pulmonary and hepatic tissue was studied in 12 patients in whom pulmonary and portal hypertension coexisted. Plexogenic pulmonary arteriopathy was present in 10 patients, 7 of whom had coexistent thromboembolic lesions. One patient had isolated medial hypertrophy, which may be an early stage in the plexogenic category, whereas isolated thromboembolic pulmonary vascular disease was observed in one subject. Hepatic disease was consistent with alcoholic cirrhosis in seven patients, cryptogenic cirrhosis in four and extrahepatic portal hypertension without cirrhosis in one. Thrombocytopenia was present in all 10 patients whose platelet count was determined. This study suggests that pulmonary hypertension associated with portal hypertension commonly has a plexogenic appearance on histologic examination. However, thrombosis (whether embolic or in situ) may also contribute to vascular obstruction.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Edwards BS,Weir EK,Edwards WD,Ludwig J,Dykoski RK,Edwards JE

doi

10.1016/s0735-1097(87)80123-7

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

1233-8

issue

6

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(87)80123-7

journal_volume

10

pub_type

杂志文章

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