Estimating Longitudinal Risks and Benefits From Cardiovascular Preventive Therapies Among Medicare Patients: The Million Hearts Longitudinal ASCVD Risk Assessment Tool: A Special Report From the American Heart Association and American College of Cardiolog

Abstract:

:The Million Hearts Initiative has a goal of preventing 1 million heart attacks and strokes-the leading causes of mortality-through several public health and healthcare strategies by 2017. The American Heart Association and American College of Cardiology support the program. The Cardiovascular Risk Reduction Model was developed by Million Hearts and the Center for Medicare & Medicaid Services as a strategy to assess a value-based payment approach toward reduction in 10-year predicted risk of atherosclerotic cardiovascular disease (ASCVD) by implementing cardiovascular preventive strategies to manage the "ABCS" (aspirin therapy in appropriate patients, blood pressure control, cholesterol management, and smoking cessation). The purpose of this special report is to describe the development and intended use of the Million Hearts Longitudinal ASCVD Risk Assessment Tool. The Million Hearts Tool reinforces and builds on the "2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk" by allowing clinicians to estimate baseline and updated 10-year ASCVD risk estimates for primary prevention patients adhering to the appropriate ABCS over time, alone or in combination. The tool provides updated risk estimates based on evidence from high-quality systematic reviews and meta-analyses of the ABCS therapies. This novel approach to personalized estimation of benefits from risk-reducing therapies in primary prevention may help target therapies to those in whom they will provide the greatest benefit, and serves as the basis for a Center for Medicare & Medicaid Services program designed to evaluate the Million Hearts Cardiovascular Risk Reduction Model.

journal_name

J Am Coll Cardiol

authors

Lloyd-Jones DM,Huffman MD,Karmali KN,Sanghavi DM,Wright JS,Pelser C,Gulati M,Masoudi FA,Goff DC Jr

doi

10.1016/j.jacc.2016.10.018

subject

Has Abstract

pub_date

2017-03-28 00:00:00

pages

1617-1636

issue

12

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(16)36692-X

journal_volume

69

pub_type

杂志文章
  • Echocardiographic-morphologic correlations in tricuspid atresia.

    abstract:OBJECTIVES:Our aim was to clarify the anatomic substrate in hearts diagnosed as having tricuspid atresia by studying autopsy specimens and comparing the findings with those in two-dimensional echocardiograms. BACKGROUND:Traditionally, tricuspid atresia was thought, and is still believed by some, to be due to an imperf...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(95)00250-8

    authors: Orie JD,Anderson C,Ettedgui JA,Zuberbuhler JR,Anderson RH

    更新日期:1995-09-01 00:00:00

  • Epicardial coronary artery tone and reactivity in patients with normal coronary arteriograms and reduced coronary flow reserve (syndrome X)

    abstract::The vasomotor response of proximal and distal angiographically normal coronary artery segments was studied in 12 patients with syndrome X, 17 age- and gender-matched patients with chronic stable angina and 10 control subjects with atypical chest pain and a normal coronary arteriogram. Ergonovine (300 micrograms by int...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(10)80216-5

    authors: Kaski JC,Tousoulis D,Galassi AR,McFadden E,Pereira WI,Crea F,Maseri A

    更新日期:1991-07-01 00:00:00

  • Health status identifies heart failure outpatients at risk for hospitalization or death.

    abstract:OBJECTIVES:We tested the hypothesis that one health status measure, the Kansas City Cardiomyopathy Questionnaire (KCCQ), provides prognostic information independent of other clinical data in outpatients with heart failure (HF). BACKGROUND:Health status measures are used to describe a patient's clinical condition and h...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2005.11.021

    authors: Heidenreich PA,Spertus JA,Jones PG,Weintraub WS,Rumsfeld JS,Rathore SS,Peterson ED,Masoudi FA,Krumholz HM,Havranek EP,Conard MW,Williams RE,Cardiovascular Outcomes Research Consortium.

    更新日期:2006-02-21 00:00:00

  • Dispersion of monophasic action potential duration: demonstrable in humans after premature ventricular extrastimulation but not in steady state.

    abstract::Abnormal dispersion of repolarization may contribute to the arrhythmogenic physiologic substrate of ventricular arrhythmia. Geographic dispersion of monophasic action potential duration was determined in steady state (drive cycle lengths 600 and 430 ms) between widely spaced right ventricular endocardial sites (geogra...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(92)90331-g

    authors: Morgan JM,Cunningham D,Rowland E

    更新日期:1992-05-01 00:00:00

  • Relation between volume of exercise and clinical outcomes in patients with heart failure.

    abstract:OBJECTIVES:This study determined whether greater volumes of exercise were associated with greater reductions in clinical events. BACKGROUND:The HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial showed that among patients with heart failure (HF), regular exercise confers a ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jacc.2012.08.958

    authors: Keteyian SJ,Leifer ES,Houston-Miller N,Kraus WE,Brawner CA,O'Connor CM,Whellan DJ,Cooper LS,Fleg JL,Kitzman DW,Cohen-Solal A,Blumenthal JA,Rendall DS,Piña IL,HF-ACTION Investigators.

    更新日期:2012-11-06 00:00:00

  • Risk stratification before thrombolytic therapy in patients with acute myocardial infarction. The Thrombolysis in Myocardial Infarction (TIMI) Phase II Co-Investigators.

    abstract::Several studies in the prethrombolytic era on the treatment of acute myocardial infarction identified selected variables from the patient's history, physical examination, chest roentgenogram and electrocardiogram that could be used to estimate mortality in patients with evolving infarction. To extend such assessment t...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(90)90579-e

    authors: Hillis LD,Forman S,Braunwald E

    更新日期:1990-08-01 00:00:00

  • Mechanism and location of atrial flutter in transplanted hearts: observations during transient entrainment from distant sites.

    abstract:OBJECTIVES:This study was designed to elucidate the location and mechanism of typical atrial flutter in the transplanted heart. BACKGROUND:Although the F wave morphology in atrial flutter is similar in nontransplanted and transplanted hearts, the surgical incision needed for the atrial anastomosis may create a distinc...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(97)00186-1

    authors: Arenal A,Almendral J,Muñoz R,Villacastín J,Merino JL,Palomo J,García Robles JA,Peinado R,Delcán JL

    更新日期:1997-08-01 00:00:00

  • Clinical correlates of PR-segment depression in asymptomatic patients with pericardial effusion.

    abstract:OBJECTIVES:The purpose of this study was to determine the clinical correlates of PR-segment depression among consecutive asymptomatic patients with pericardial effusion (PE) detected by routine echocardiography. BACKGROUND:Pericardial effusion is a relatively common finding in clinical practice, but not many studies h...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(02)01889-2

    authors: Kudo Y,Yamasaki F,Doi Y,Sugiura T

    更新日期:2002-06-19 00:00:00

  • Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement.

    abstract:OBJECTIVES:The aim of this study was to evaluate the relative impact of demographic and clinical variables versus the cytochrome P450 2C19 (CYP2C19) polymorphism on antiplatelet effects of clopidogrel. BACKGROUND:Platelet responses to clopidogrel show a marked interindividual variability with substantial impact on cli...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jacc.2010.02.031

    authors: Hochholzer W,Trenk D,Fromm MF,Valina CM,Stratz C,Bestehorn HP,Büttner HJ,Neumann FJ

    更新日期:2010-06-01 00:00:00

  • Diagnosis of coronary stenosis by two-dimensional echographic study of dysfunction of ventricular segments during and immediately after pacing.

    abstract::The adequacy of two-dimensional echocardiography during right atrial pacing for the detection and characterization of coronary artery stenosis was examined in 10 closed chest dogs. Pacing at successively higher rates up to 210 beats/min was carried out in the control state and again during a 70% left anterior descendi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(83)80309-x

    authors: Kondo S,Meerbaum S,Sakamaki T,Shimoura K,Tei C,Shah PM,Corday E

    更新日期:1983-10-01 00:00:00

  • Effect of prior myocardial infarction and extent and location of coronary disease on accuracy of exercise echocardiography.

    abstract::Exercise echocardiography is an emerging technique for the evaluation of patients with suspected coronary artery disease. In this study, rest and immediate postexercise echocardiograms were performed in 123 patients who were stratified on the basis of prior myocardial infarction and the number and location of coronary...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80195-x

    authors: Armstrong WF,O'Donnell J,Ryan T,Feigenbaum H

    更新日期:1987-09-01 00:00:00

  • Direct coronary angioplasty in acute myocardial infarction: outcome in patients with single vessel disease.

    abstract::Percutaneous transluminal coronary angioplasty was performed as primary therapy in 215 consecutive patients (aged 56 +/- 11 years, 75% male) with acute myocardial infarction and single vessel coronary artery disease. Wide patency of the infarct-related artery was restored in 212 patients (99%). Complications consisted...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(90)90621-u

    authors: Stone GW,Rutherford BD,McConahay DR,Johnson WL Jr,Giorgi LV,Ligon RW,Hartzler GO

    更新日期:1990-03-01 00:00:00

  • The QT interval is associated with incident cardiovascular events: the MESA study.

    abstract:BACKGROUND:Prolonged heart rate-corrected QT interval on electrocardiograms (ECGs) is associated with increased risk of myocardial infarction and cardiovascular disease (CVD)-related deaths in patients with prevalent coronary heart disease. OBJECTIVES:This study sought to examine the prognostic association between the...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2014.08.039

    authors: Beinart R,Zhang Y,Lima JA,Bluemke DA,Soliman EZ,Heckbert SR,Post WS,Guallar E,Nazarian S

    更新日期:2014-11-18 00:00:00

  • Left Ventricular Noncompaction: A Distinct Genetic Cardiomyopathy?

    abstract::Left ventricular noncompaction (LVNC) describes a ventricular wall anatomy characterized by prominent left ventricular (LV) trabeculae, a thin compacted layer, and deep intertrabecular recesses. Individual variability is extreme, and trabeculae represent a sort of individual "cardioprinting." By itself, the diagnosis ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2016.05.096

    authors: Arbustini E,Favalli V,Narula N,Serio A,Grasso M

    更新日期:2016-08-30 00:00:00

  • Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction.

    abstract::To evaluate the feasibility of detecting denervated myocardium in the infarcted canine heart, the distribution of sympathetic nerve endings using I-123 metaiodobenzylguanidine (MIBG) was compared with the distribution of perfusion using thallium-201, with the aid of color-coded computer functional map in 16 dogs. Twel...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(10)80156-1

    authors: Dae MW,Herre JM,O'Connell JW,Botvinick EH,Newman D,Munoz L

    更新日期:1991-05-01 00:00:00

  • Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects.

    abstract:OBJECTIVES:This study sought to determine the relationship between vascular disease in different arterial territories and advanced age. BACKGROUND:Vascular disease in the peripheral circulation is associated with significant morbidity and mortality. There is little data to assess the prevalence of different phenotypes...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2013.01.054

    authors: Savji N,Rockman CB,Skolnick AH,Guo Y,Adelman MA,Riles T,Berger JS

    更新日期:2013-04-23 00:00:00

  • In vivo detection of reperfused myocardium by nuclear magnetic resonance imaging.

    abstract::To assess the potential of in vivo nuclear magnetic resonance imaging for the detection of reperfused myocardium, in vivo T2-weighted spin echo images were obtained of dogs at 0.15 tesla. Imaging was done during 3 hours of coronary occlusion (group I), and during 3 hours of coronary occlusion followed by 1 hour of rep...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80091-8

    authors: Johnston DL,Liu P,Rosen BR,Levine RA,Beaulieu PA,Brady TJ,Okada RD

    更新日期:1987-01-01 00:00:00

  • Mechanism of prevention of sudden death by nadolol: differential actions on arrhythmia triggers and substrate after myocardial infarction in the dog.

    abstract::Electrocardiographic monitoring and provocative ventricular pacing were used to evaluate control and nadolol treatment groups 6 to 24 hours after left anterior descending coronary artery ligation in the dog. During the 6 to 24 hour period, the control group (n = 20) developed ventricular triplets at rates exceeding 27...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(86)80309-6

    authors: Patterson E,Scherlag BJ,Lazzara R

    更新日期:1986-12-01 00:00:00

  • Relationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging.

    abstract:OBJECTIVES:The aim of this study was to perform a head-to-head comparison between multi-slice computed tomography (MSCT) and myocardial perfusion imaging (MPI) in patients with an intermediate likelihood of coronary artery disease (CAD) and to compare non-invasive findings to invasive coronary angiography. BACKGROUND:...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2006.05.080

    authors: Schuijf JD,Wijns W,Jukema JW,Atsma DE,de Roos A,Lamb HJ,Stokkel MP,Dibbets-Schneider P,Decramer I,De Bondt P,van der Wall EE,Vanhoenacker PK,Bax JJ

    更新日期:2006-12-19 00:00:00

  • Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial.

    abstract:OBJECTIVES:The purpose of this study is to evaluate the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery (CABG), as a post-randomization strategy. BACKGROUND:Ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y(12)-...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2010.10.029

    authors: Held C,Asenblad N,Bassand JP,Becker RC,Cannon CP,Claeys MJ,Harrington RA,Horrow J,Husted S,James SK,Mahaffey KW,Nicolau JC,Scirica BM,Storey RF,Vintila M,Ycas J,Wallentin L

    更新日期:2011-02-08 00:00:00

  • Circadian variability in the occurrence of sudden cardiac death in patients with hypertrophic cardiomyopathy.

    abstract:OBJECTIVES:The present study examined whether sudden death in patients with hypertrophic cardiomyopathy occurred with a particular pattern of frequency throughout the day. BACKGROUND:Previous investigators have shown a circadian distribution in the occurrence of sudden death and other cardiovascular events in patients...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90384-0

    authors: Maron BJ,Kogan J,Proschan MA,Hecht GM,Roberts WC

    更新日期:1994-05-01 00:00:00

  • Plasma tissue factor plus activated peripheral mononuclear cells activate factors VII and X in cardiac surgical wounds.

    abstract:OBJECTIVES:The purpose of this study was to test the hypothesis that activated monocytes with soluble plasma tissue factor (pTF) activate factors VII and X to generate thrombin. BACKGROUND:Despite heparin, thrombin is progressively generated during cardiac surgery with cardiopulmonary bypass (CPB), produces intravascu...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2005.05.040

    authors: Hattori T,Khan MM,Colman RW,Edmunds LH Jr

    更新日期:2005-08-16 00:00:00

  • Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative.

    abstract:BACKGROUND:Reproductive factors reflective of endogenous sex hormone exposure might have an effect on cardiac remodeling and the development of heart failure (HF). OBJECTIVES:This study examined the association between key reproductive factors and the incidence of HF. METHODS:Women from a cohort of the Women's Health...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2017.03.557

    authors: Hall PS,Nah G,Howard BV,Lewis CE,Allison MA,Sarto GE,Waring ME,Jacobson LT,Manson JE,Klein L,Parikh NI

    更新日期:2017-05-23 00:00:00

  • Benign congenital intracardiac thyroid and polycystic tumor causing right ventricular outflow tract obstruction and conduction disturbance.

    abstract::A patient with a rare intracardiac tumor arising from the right side of the interventricular septum who developed conduction disturbances and symptoms of right ventricular outflow tract obstruction is reported. The patient was successfully treated with insertion of a permanent pacemaker and surgical removal of the tum...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80105-5

    authors: Grigg LE,Downey W,Tatoulis J,Hunt D

    更新日期:1987-01-01 00:00:00

  • Use of electrophysiologic testing in patients with nonsustained ventricular tachycardia: prognostic and therapeutic implications.

    abstract::Forty patients with coronary artery disease and nonsustained ventricular tachycardia on ambulatory electrocardiographic monitoring underwent programmed electrical stimulation. In 22 patients, monomorphic ventricular tachycardia was induced at baseline drug-free electrophysiologic testing; 9 of these patients subsequen...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(89)90066-1

    authors: Klein RC,Machell C

    更新日期:1989-07-01 00:00:00

  • Interassociation Consensus Statement on Cardiovascular Care of College Student-Athletes.

    abstract::Cardiovascular evaluation and care of college student-athletes is gaining increasing attention from both the public and medical communities. Emerging strategies include screening of the general athlete population, recommendations of permissible levels of participation by athletes with identified cardiovascular conditi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 共识发展会议,杂志文章

    doi:10.1016/j.jacc.2016.03.527

    authors: Hainline B,Drezner JA,Baggish A,Harmon KG,Emery MS,Myerburg RJ,Sanchez E,Molossi S,Parsons JT,Thompson PD

    更新日期:2016-06-28 00:00:00

  • The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease.

    abstract:OBJECTIVES:This study was designed to examine the use of cardiovascular medications and outcomes in patients with heart failure (HF) and renal dysfunction. BACKGROUND:Renal insufficiency is associated with poorer outcomes in patients with HF, but the mechanisms are uncertain. In particular, the degree of therapeutic n...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.06.072

    authors: Ezekowitz J,McAlister FA,Humphries KH,Norris CM,Tonelli M,Ghali WA,Knudtson ML,APPROACH Investigators.

    更新日期:2004-10-19 00:00:00

  • Changing strategies in the management of heart failure.

    abstract::Forty years ago therapy for congestive heart failure was limited largely to the mercurial diuretics and a variety of cardiac glycoside preparations; these were often ineffective, and the common practice of "pushing" digitalis caused serious, sometimes lethal side effects. Today, a more complete understanding of the re...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/0735-1097(89)90586-x

    authors: Katz AM

    更新日期:1989-03-01 00:00:00

  • Emergency stenting to treat neurological complications occurring after carotid endarterectomy.

    abstract:OBJECTIVES:The purpose of this study was to assess the efficacy of emergency stent implantation for the treatment of perioperative stroke after carotid endarterectomy (CEA). BACKGROUND:Carotid endarterectomy has been proven safe and effective in reducing the risk of stroke in symptomatic and asymptomatic patients with...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01284-0

    authors: Anzuini A,Briguori C,Roubin GS,Pagnotta P,Rosanio S,Airoldi F,Carlino M,Pagnotta P,Di Mario C,Sheiban I,Magnani G,Jannello A,Melissano G,Chiesa R,Colombo A

    更新日期:2001-06-15 00:00:00

  • Imaging systemic inflammatory networks in ischemic heart disease.

    abstract::While acute myocardial infarction mortality declines, patients continue to face reinfarction and/or heart failure. The immune system, which intimately interacts with healthy and diseased tissues through resident and recruited leukocytes, is a central interface for a global host response to ischemia. Pathways that enha...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2015.02.034

    authors: Nahrendorf M,Frantz S,Swirski FK,Mulder WJ,Randolph G,Ertl G,Ntziachristos V,Piek JJ,Stroes ES,Schwaiger M,Mann DL,Fayad ZA

    更新日期:2015-04-21 00:00:00