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The QT interval is associated with incident cardiovascular events: the MESA study.

Abstract：

BACKGROUND:Prolonged heart rate-corrected QT interval on electrocardiograms (ECGs) is associated with increased risk of myocardial infarction and cardiovascular disease (CVD)-related deaths in patients with prevalent coronary heart disease. OBJECTIVES:This study sought to examine the prognostic association between the baseline QT interval and incident cardiovascular events in individuals without prior known CVD. METHODS:The corrected baseline 12-lead ECG QT interval duration (QTcorr) was determined by adjustment for age, sex, race/ethnicity, and RR interval duration in 6,273 participants in MESA (Multi-Ethnic Study of Atherosclerosis). Cox proportional hazards models adjusting for demographic and clinical risk factors were used to examine the association of baseline QTcorr with incident cardiovascular events. RESULTS:The mean age at enrollment was 61.7 ± 10 years, and 53.4% of participants were women. Cardiovascular events occurred in 291 participants over a mean follow-up of 8.0 ± 1.7 years. Each 10-ms increase in the baseline QTcorr was associated with incident heart failure (hazard ratio [HR]: 1.25; 95% CI: 1.14 to 1.37), CVD events (HR: 1.12; 95% CI: 1.05 to 1.20), and stroke (HR: 1.19; 95% CI: 1.07 to 1.32) after adjustment for CVD risk factors and potential confounders. There was no evidence of interaction with sex or ethnicity. CONCLUSIONS:The QT interval was associated with incident cardiovascular events in middle-aged and older adults without prior CVD.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Beinart R,Zhang Y,Lima JA,Bluemke DA,Soliman EZ,Heckbert SR,Post WS,Guallar E,Nazarian S

doi

10.1016/j.jacc.2014.08.039

subject

Has Abstract

pub_date

2014-11-18 00:00:00

pages

2111-9

issue

20

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(14)06209-3

journal_volume

64

pub_type

杂志文章

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