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From Focal Lipid Storage to Systemic Inflammation: JACC Review Topic of the Week.

Abstract：

:Concepts of atherogenesis have evolved considerably with time. Early animal experiments showed that a cholesterol-rich diet could induce fatty lesion formation in arteries. The elucidation of lipoprotein metabolism ultimately led to demonstrating the clinical benefits of lipid lowering. The view of atheromata as bland accumulations of smooth muscle cells that elaborated an extracellular matrix that could entrap lipids then expanded to embrace inflammation as providing pathways that could link risk factors to atherogenesis. The characterization of leukocyte adhesion molecules and their control by proinflammatory cytokines, the ability of chemokines to recruit leukocytes, and the identification of inflammatory cell subtypes in lesions spurred the unraveling of innate and adaptive immune pathways that contribute to atherosclerosis and its thrombotic complications. Such pathophysiologic insights have led to the identification of biomarkers that can define categories of risk and direct therapies and to the development of new treatments.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Libby P,Hansson GK

doi

10.1016/j.jacc.2019.07.061

subject

Has Abstract

pub_date

2019-09-24 00:00:00

pages

1594-1607

issue

12

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(19)36161-3

journal_volume

74

pub_type

杂志文章,评审

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