Abstract:
OBJECTIVES:Using both in vitro and in vivo techniques, we investigated the extent to which cardiac motion alters Doppler-measured blood flow velocity and thus potentially can alter the calculation of valve areas or pressure gradients. BACKGROUND:Blood flow velocity measured by Doppler ultrasound represents the net motion of the blood relative to the transducer. It is widely assumed that the measured velocity represents the actual flow. It has been demonstrated that cardiac motion generates regularly occurring low velocity Doppler signals that are commonly treated as artifact. METHODS:We used an in vitro model that allowed us to measure and independently control the flow of a liquid through a chamber and the motion of the chamber relative to the Doppler beam. A cornstarch-water slurry was driven by a pulsatile pump through tubing to simulate the blood flow within the heart, and the tubing was cyclically moved by a piston to simulate the heart motion. We also measured cardiac motion using M-mode and two-dimensional echocardiography and compared the results with the Doppler signal derived from cardiac motion in subjects without cardiac disease. RESULTS:In the in vitro model, alteration in the motion of the tubing resulted in apparent changes in the measured maximal velocity of the fluid. The Doppler spectrum of the combined motion of the tubing and the fluid was the algebraic sum of their Doppler signals. In human subjects, the maximal slope of the M-mode tracing of the aortic annular motion and the peak Doppler signal due to cardiac motion were compared and were highly correlated. CONCLUSIONS:Cardiac motion alters the Doppler signal derived from blood flow. This effect can be demonstrated in vitro and in vivo.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Cao T,Shapiro SM,Bersohn MM,Liu SC,Ginzton LEdoi
10.1016/0735-1097(93)90843-psubject
Has Abstractpub_date
1993-07-01 00:00:00pages
271-6issue
1eissn
0735-1097issn
1558-3597pii
0735-1097(93)90843-Pjournal_volume
22pub_type
杂志文章abstract:OBJECTIVES:We investigated whether the serum markers of collagen turnover differed in various forms of atrial fibrillation (AF) and in sinus rhythm (SR) in humans. BACKGROUND:Structural alterations and fibrosis have been implicated in the generation and perpetuation of AF. METHODS:Serum C-terminal propeptide of colla...
journal_title:Journal of the American College of Cardiology
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更新日期:2008-07-15 00:00:00
abstract:BACKGROUND:The currently recommended duration of dual antiplatelet therapy (DAPT) in drug-eluting stent (DES) recipients is 12 months to reduce the risk of late stent thrombosis, particularly in those with acute coronary syndrome (ACS). OBJECTIVES:This study hypothesized that antiplatelet treatment with DAPT for 6 mon...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-03-03 00:00:00
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更新日期:2000-11-15 00:00:00
abstract::The mechanism of electrocardiographic ST segment changes during acute coronary occlusion was evaluated in 28 consecutive patients with single vessel coronary artery disease undergoing coronary angioplasty. Patients were continuously monitored with a six lead electrocardiogram. Twenty-three patients showed ST changes i...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(85)80250-3
更新日期:1985-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1984-06-01 00:00:00
abstract::A total of 333 patients arriving within 6 h of the onset of suspected or proven but uncomplicated myocardial infarction were randomized to treatment by either the prophylactic or the selective lidocaine strategy. Patients were monitored for 24 h. The major end points were sustained ventricular tachycardia or fibrillat...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:Cardiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (HT). Angiotensin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well studied after HT. OBJECTIVES:This study tested the safety and efficacy of the ACEI ramipril on...
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更新日期:2017-06-13 00:00:00
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更新日期:1994-06-01 00:00:00
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更新日期:2012-04-17 00:00:00
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更新日期:2002-08-07 00:00:00
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pub_type: 指南,杂志文章
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更新日期:1993-01-01 00:00:00
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更新日期:1999-11-01 00:00:00
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更新日期:2003-04-02 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2005.11.056
更新日期:2006-04-04 00:00:00
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更新日期:2001-12-01 00:00:00
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更新日期:2017-01-17 00:00:00
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更新日期:2009-03-17 00:00:00
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更新日期:2010-04-27 00:00:00
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更新日期:1998-03-15 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1994-12-01 00:00:00
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更新日期:2016-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2017.12.054
更新日期:2018-03-06 00:00:00
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更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:This study sought to determine the incidence of aspirin nonresponsiveness in addition to clopidogrel nonresponsiveness and whether this association identifies patients at an increased risk of drug-eluting stent (DES) thrombosis. BACKGROUND:Nonresponsiveness to clopidogrel is a predictor of DES thrombosis. N...
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更新日期:2008-08-26 00:00:00
abstract:OBJECTIVES:The aim of the present study was to investigate whether there is diurnal fluctuation in the endothelial function of patients with variant angina (VA). BACKGROUND:Coronary spasm is induced by acetylcholine and is promptly relieved by nitroglycerin. Thus, it is possible that endothelial dysfunction is involve...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(02)01956-3
更新日期:2002-07-17 00:00:00
abstract::Two patients with complete heart block complicating extensive anterior myocardial infarction underwent late (greater than 40 hours) coronary reperfusion with angioplasty. One to one atrioventricular conduction was restored within minutes of reperfusion despite a lack of measurable ventricular muscle salvage as demonst...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(84)80156-4
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:In patients with coronary artery disease (CAD), low diastolic blood pressure (DBP) is associated with increased risk of myocardial infarction, but its association with angina is unknown. OBJECTIVES:The goal of this study was to examine the association of low DBP and angina in patients with CAD. METHODS:The...
journal_title:Journal of the American College of Cardiology
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更新日期:2018-09-11 00:00:00
abstract:OBJECTIVES:This study sought to evaluate the prognostic value of wavelet correlation functions of the signal-averaged electrocardiogram (ECG) for arrhythmic events in patients after myocardial infarction. BACKGROUND:Wavelet transform of the signal-averaged ECG has been shown to be a nonstationary analysis technique de...
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更新日期:1996-01-01 00:00:00