当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography.

Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography.

Abstract：

OBJECTIVES:The aim of this study was to compare treadmill exercise (TEX) and dipyridamole stress on the uptake and retention of N-13 ammonia. BACKGROUND:Size and severity of stress-induced myocardial perfusion defects are clinically important. Because ammonia uptake and retention seems to be related to perfusion, viability, and metabolism, exercise stress might induce larger perfusion defects than dipyridamole stress. METHODS:Twenty-six patients underwent TEX and dipyridamole stress N-13 ammonia positron emission tomography (PET). Images were assessed with a 17-segment model and a five-point score. Summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) were calculated. Left ventricular (LV) defect sizes were measured quantitatively with a 70% threshold for abnormal perfusion. RESULTS:Compared with dipyridamole stress, TEX yielded larger SSS (9.1 +/- 5.7 vs. 6.9 +/- 5.9; p < 0.01), SDS (5.8 +/- 4.7 vs. 3.7 +/- 4.6; p < 0.02), and percentage of LV stress defect (19.3 +/- 11.5% vs. 13.8 +/- 13.6%; p < 0.02). CONCLUSIONS:In patients achieving adequate exercise, TEX N-13 ammonia PET myocardial perfusion imaging (MPI) yields larger stress perfusion defects than dipyridamole stress and might reflect the true myocardial ischemic burden. Treadmill exercise might be the preferred method of stress for routine N-13 ammonia PET MPI.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Chow BJ,Beanlands RS,Lee A,DaSilva JN,deKemp RA,Alkahtani A,Ruddy TD

doi

10.1016/j.jacc.2005.09.027

subject

Has Abstract

pub_date

2006-01-17 00:00:00

pages

411-6

issue

2

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(05)02578-7

journal_volume

47

pub_type

杂志文章,随机对照试验

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