Abstract:
OBJECTIVES:This clinical trial was performed to determine the safety and clinical impact of titrated metoprolol therapy in patients with heart failure, documented coronary artery disease and a low ejection fraction. BACKGROUND:Despite known cardiodepressant effects, long-term use of beta-adrenergic antagonists appears to be beneficial in patients with idiopathic dilated cardiomyopathy. However, this therapy has not been critically evaluated in patients with heart failure and coronary artery disease. METHODS:In 50 patients with heart failure, known coronary artery disease and an ejection fraction < or = 0.40, we examined the impact of metoprolol therapy in a 6-month double-blind, placebo-controlled randomized trial, assessing the frequency of heart failure exacerbations and changes in symptoms (New York Heart Association functional class), ejection fraction and exercise duration. Placebo-treated patients who completed 6-month follow-up studies then underwent a trial with metoprolol therapy (crossover group). RESULTS:Metoprolol was titrated to a mean maximal dose of 87 mg/day (range 25 to 100) without serious adverse reactions. During double-blind therapy, use of a beta-blocker was associated with a significant reduction in the number of hospital admissions (4% vs. 32%, p < 0.05), overall improved functional class (p = 0.02), increased ejection fraction (4 +/- 7% [mean +/- SD] compared with 0 +/- 6%, p < 0.05) and a greater increase in exercise duration (193 +/- 276 vs. 38 +/- 213 s with placebo, p < 0.01). Crossover outcome paralleled the favorable impact seen during randomized metoprolol therapy. CONCLUSIONS:Cautious use of titrated metoprolol appears to be safe and beneficial when added to standard heart failure therapy in patients with dilated cardiomyopathy associated with coronary artery disease.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Fisher ML,Gottlieb SS,Plotnick GD,Greenberg NL,Patten RD,Bennett SK,Hamilton BPdoi
10.1016/0735-1097(94)90641-6subject
Has Abstractpub_date
1994-03-15 00:00:00pages
943-50issue
4eissn
0735-1097issn
1558-3597pii
0735-1097(94)90641-6journal_volume
23pub_type
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journal_title:Journal of the American College of Cardiology
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更新日期:2007-03-27 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Journal of the American College of Cardiology
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更新日期:1988-09-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
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pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1998-12-01 00:00:00
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更新日期:1991-05-01 00:00:00
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doi:10.1016/s0735-1097(00)00960-8
更新日期:2000-11-15 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(90)90222-b
更新日期:1990-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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更新日期:2014-06-24 00:00:00
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更新日期:2019-05-21 00:00:00
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更新日期:2004-09-15 00:00:00
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更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1985-10-01 00:00:00
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更新日期:2013-11-12 00:00:00
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更新日期:2018-12-11 00:00:00
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更新日期:2017-06-27 00:00:00
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更新日期:1996-12-01 00:00:00
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更新日期:1998-12-01 00:00:00