Effects of mibefradil, a novel calcium channel blocking agent with T-type activity, in acute experimental myocardial ischemia: maintenance of ventricular fibrillation threshold without inotropic compromise.

Abstract:

OBJECTIVES:We tested whether mibefradil, a selective T-type calcium channel blocking agent, could differentially inhibit experimental ventricular arrhythmogenesis more than contractility during acute regional ischemia and reperfusion compared with that during L-channel blockade by verapamil. BACKGROUND:T-type calcium channels are found in nodal and conduction tissue and in vascular smooth muscle, but in much lower density in contractile myocardium. The potential role of mibefradil in ventricular arrhythmogenesis remains unclear. METHODS:Mibefradil (Ro 40-5967, 1 mg/kg body weight intravenously [i.v.]) was given as a bolus 30 min before anterior descending coronary artery ligation, followed by 2 mg/kg per h i.v. during 20 min of ischemia and 25 min of reperfusion in open chest pigs. In a second group, mibefradil was given in a dose twice as high. A third group received verapamil (0.3 mg/kg i.v.), followed by an infusion of 0.6 mg/kg per h. RESULTS:During the ischemic period, the low (clinically relevant) dose of mibefradil prevented the fall of the ventricular fibrillation threshold, without depressing the maximal rate of pressure development of the left ventricle (LVmax dP/dt). This low dose increased left ventricular blood flow, whereas peripheral arterial pressure remained unchanged. The higher dose of both mibefradil and verapamil was antiarrhythmic during ischemia, at the cost of depressed contractile activity. During reperfusion, only the higher dose of mibefradil and verapamil was antiarrhythmic but both depressed contractile activity. CONCLUSIONS:Mibefradil is antiarrhythmic, without inotropic compromise. Speculatively, both T-type and L-type calcium channel blockade are involved in these effects.

journal_name

J Am Coll Cardiol

authors

Muller CA,Opie LH,McCarthy J,Hofmann D,Pineda CA,Peisach M

doi

10.1016/s0735-1097(98)00182-x

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

268-74

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(98)00182-X

journal_volume

32

pub_type

杂志文章
  • Primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT). A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath.

    abstract:OBJECTIVES:The purpose of this study was to examine the relationships among B-type natriuretic peptide (BNP) levels within the diagnostic range, perceived congestive heart failure (CHF) severity, clinical decision making, and outcomes of the CHF patients presenting to emergency department (ED). BACKGROUND:Since BNP co...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.jacc.2004.06.015

    authors: Maisel A,Hollander JE,Guss D,McCullough P,Nowak R,Green G,Saltzberg M,Ellison SR,Bhalla MA,Bhalla V,Clopton P,Jesse R,Rapid Emergency Department Heart Failure Outpatient Trial investigators.

    更新日期:2004-09-15 00:00:00

  • Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance.

    abstract:UNLABELLED:We evaluated the response to clopidogrel among aspirin-resistant versus aspirin-sensitive patients undergoing elective coronary stenting. Patients (n = 150) treated with aspirin but not clopidogrel had blood samples drawn at baseline and 24 h after clopidogrel loading. Depending on the definition used, 9% to...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2005.08.058

    authors: Lev EI,Patel RT,Maresh KJ,Guthikonda S,Granada J,DeLao T,Bray PF,Kleiman NS

    更新日期:2006-01-03 00:00:00

  • STICH (Surgical Treatment for Ischemic Heart Failure) trial enrollment.

    abstract:OBJECTIVES:The aim of this study was to assess the influence of enrolling site location and enrollment performance on the generalizability of STICH (Surgical Treatment for Ischemic Heart Failure) trial results. BACKGROUND:The international STICH trial seeks to define the role of cardiac surgery for patients with ische...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jacc.2009.11.102

    authors: Jones RH,White H,Velazquez EJ,Shaw LK,Pietrobon R,Panza JA,Bonow RO,Sopko G,O'Connor CM,Rouleau JL

    更新日期:2010-08-03 00:00:00

  • Percutaneous transluminal coronary angioplasty in the elderly: early and long-term results.

    abstract::The immediate and long-term efficacy of coronary angioplasty in the elderly was determined by studying 752 patients greater than or equal to 65 years old and comparing patients greater than or equal to 75 years old with those 65 to 74 years old. The oldest patients were more highly symptomatic, were more likely to be ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(10)80130-5

    authors: Thompson RC,Holmes DR Jr,Gersh BJ,Mock MB,Bailey KR

    更新日期:1991-05-01 00:00:00

  • Platelet glycoprotein IIb/IIIa receptor blockade and coronary resistance in unstable angina.

    abstract:OBJECTIVES:We designed a study to explore the effect of glycoprotein (GP) IIb/IIIa blockade on the atherosclerotic plaque and distal coronary vasculature. BACKGROUND:Platelet GP IIb/IIIa blockers have been proven to be beneficial in acute ischemic syndromes. This effect has also been attributed to the prevention of mi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0735-1097(02)02590-1

    authors: Marzilli M,Sambuceti G,Testa R,Fedele S

    更新日期:2002-12-18 00:00:00

  • Prevention of recurrent lone atrial fibrillation by the angiotensin-II converting enzyme inhibitor ramipril in normotensive patients.

    abstract:OBJECTIVES:The aim of the present study was to verify whether angiotensin-II converting enzyme (ACE) inhibition is also effective in preventing relapses of lone atrial fibrillation (LAF), that is, in the absence of hypertension and/or heart disease. BACKGROUND:Several studies have shown that ACE inhibitors are effecti...

    journal_title:Journal of the American College of Cardiology

    pub_type: 评论,杂志文章,随机对照试验

    doi:10.1016/j.jacc.2008.08.071

    authors: Belluzzi F,Sernesi L,Preti P,Salinaro F,Fonte ML,Perlini S

    更新日期:2009-01-06 00:00:00

  • Assessment of left ventricular contractile state by preload-adjusted maximal power using echocardiographic automated border detection.

    abstract:OBJECTIVES:We sought to assess the ability of preload-adjusted maximal power measured by echocardiographic automated border detection (ABD) to quantify left ventricular (LV) contractility by determining the effects of alterations in preload, afterload and contractile state. BACKGROUND:Preload-adjusted maximal power ca...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00005-9

    authors: Mandarino WA,Pinsky MR,Gorcsan J 3rd

    更新日期:1998-03-15 00:00:00

  • Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy. The TAMI Study Group.

    abstract:OBJECTIVES:The aim of this study was to assess the hemorrhagic risk associated with fibrin-specific thrombolytic therapy and invasive procedures with acute myocardial infarction. BACKGROUND:Successful coronary artery reperfusion has important prognostic implications. Because immediate coronary angiography is the only ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/0735-1097(93)90090-n

    authors: Wall TC,Califf RM,Ellis SG,Sigmon K,Kereiakes D,George BS,Samaha J,Sane D,Stump DC,Stack RS

    更新日期:1993-03-01 00:00:00

  • Calcium channel blocking agents and risk of cancer in patients with coronary heart disease. Benzafibrate Infarction Prevention (BIP) Study Research Group.

    abstract:OBJECTIVES:This analysis sought to estimate the risk ratio for cancer incidence and cancer-related mortality associated with the use of calcium channel blocking agents (CCBs) in a large group of patients with chronic coronary heart disease (CHD). BACKGROUND:Recent publications contend that the use of short-acting CCBs...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00008-4

    authors: Braun S,Boyko V,Behar S,Reicher-Reiss H,Laniado S,Kaplinsky E,Goldbourt U

    更新日期:1998-03-15 00:00:00

  • Plasma brain natriuretic peptide concentrations predict survival after acute myocardial infarction.

    abstract:OBJECTIVES:This study sought to examine whether plasma brain natriuretic peptide levels can predict prognosis after myocardial infarction. BACKGROUND:It has been suggested that concentrations of plasma brain natriuretic peptide reflect left ventricular function. Although the prognosis after myocardial infarction depen...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(96)00067-8

    authors: Arakawa N,Nakamura M,Aoki H,Hiramori K

    更新日期:1996-06-01 00:00:00

  • The Essential Role of Educator Development: 10 Years of the ACC Emerging Faculty Program.

    abstract::The American College of Cardiology Emerging Faculty program was developed in 2005 to promote a systematic approach to "educate the educators" through training and mentorship. A primary focus of the program is the biennial Teaching Skills Workshop, which has had 130 participants since its inception and is focused on th...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2016.02.052

    authors: Auseon AJ,O'Gara PT,Klodas E,Holmes DR Jr,Jackson MJ,Green JS,Konstam MA,Nishimura RA

    更新日期:2016-05-10 00:00:00

  • Failure of calcium channel blockers to improve ventricular relaxation in humans.

    abstract:OBJECTIVES:The objective of this study was to ascertain whether the reversal of low peak filling rates after administration of calcium channel blockers in patients with diastolic dysfunction indicates true improvement in the rate of ventricular relaxation and left ventricular end-diastolic pressure measured by invasive...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(93)90735-j

    authors: Nishimura RA,Schwartz RS,Holmes DR Jr,Tajik AJ

    更新日期:1993-01-01 00:00:00

  • Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia.

    abstract:BACKGROUND:Patients with familial hypercholesterolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-density lipoprotein cholesterol (LDL-C), which is associated with accelerated atherogenesis and increased cardiovascular risk. OBJECTIVES:This study used (18)F-fluorodeoxygluco...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2014.01.088

    authors: van Wijk DF,Sjouke B,Figueroa A,Emami H,van der Valk FM,MacNabb MH,Hemphill LC,Schulte DM,Koopman MG,Lobatto ME,Verberne HJ,Fayad ZA,Kastelein JJ,Mulder WJ,Hovingh GK,Tawakol A,Stroes ES

    更新日期:2014-10-07 00:00:00

  • Biphasic response to dobutamine predicts improvement of global left ventricular function after surgical revascularization in patients with stable coronary artery disease: implications of time course of recovery on diagnostic accuracy.

    abstract:OBJECTIVES:This study sought to evaluate the time course of improvement of left ventricular (LV) dysfunction in stable patients and its implications on the accuracy of dobutamine echocardiography for predicting improvement after surgical revascularization. BACKGROUND:Little is known about the optimal timing for evalua...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00067-9

    authors: Cornel JH,Bax JJ,Elhendy A,Maat AP,Kimman GJ,Geleijnse ML,Rambaldi R,Boersma E,Fioretti PM

    更新日期:1998-04-01 00:00:00

  • Long-term retention of cardiac resynchronization therapy.

    abstract:OBJECTIVES:The purpose of this study was to determine the frequency and causes of intermittent and permanent loss of cardiac resynchronization therapy (CRT) in patients who have undergone the successful implantation of a transvenous defibrillator that delivers CRT (CRT-D). BACKGROUND:The causes of loss of CRT have not...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.jacc.2004.03.054

    authors: Knight BP,Desai A,Coman J,Faddis M,Yong P

    更新日期:2004-07-07 00:00:00

  • Diabetic retinopathy and risk of heart failure.

    abstract:OBJECTIVES:The purpose of this study was to examine the association of diabetic retinopathy with incident heart failure (HF). BACKGROUND:Microvascular disease might play a more prominent role in the pathogenesis of diabetic cardiomyopathy, a major cause of HF in diabetes. Whether diabetic retinopathy, a microvascular ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2007.11.076

    authors: Cheung N,Wang JJ,Rogers SL,Brancati F,Klein R,Sharrett AR,Wong TY,ARIC (Atherosclerosis Risk In Communities) Study Investigators.

    更新日期:2008-04-22 00:00:00

  • Vascular remodeling during healing after myocardial infarction in the dog model: effects of reperfusion, amlodipine and enalapril.

    abstract:OBJECTIVES:We sought to determine whether reperfusion and the calcium channel blocker amlodipine or the angiotensin-converting enzyme inhibitor enalapril, during healing over six weeks after myocardial infarction (MI), limit structural vascular remodeling in the noninfarct zone (NIZ). BACKGROUND:The effect of reperfus...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(02)01805-3

    authors: Jugdutt BI,Menon V,Kumar D,Idikio H

    更新日期:2002-05-01 00:00:00

  • Ventricular function and infarct size: the Western Washington Intravenous Streptokinase in Myocardial Infarction Trial.

    abstract::The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial randomized 368 patients with symptoms and signs of acute myocardial infarction of less than 6 h duration to either conventional care or 1.5 million units of intravenous streptokinase. The mean time to randomization was 209 min and 52...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(88)90197-0

    authors: Ritchie JL,Cerqueira M,Maynard C,Davis K,Kennedy JW

    更新日期:1988-04-01 00:00:00

  • Percutaneous balloon valvuloplasty in neonates with critical aortic stenosis.

    abstract::Percutaneous balloon valvuloplasty was attempted in 10 newborn infants with critical aortic valve stenosis and severe congestive heart failure. Three had a very small left ventricle and aortic anulus. In one infant, the aortic valve could not be passed, and in another infant, a technical error resulted in severe valvu...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(89)90268-4

    authors: Kasten-Sportes CH,Piechaud JF,Sidi D,Kachaner J

    更新日期:1989-04-01 00:00:00

  • Aneurysmal degeneration of Blalock-Taussig shunts: identification and surgical treatment options.

    abstract::Many Blalock-Taussig shunts (subclavian to pulmonary artery anastomoses) have been created and a significant number are still being done. Two cases of aneurysmal degeneration of a Blalock-Taussig shunt and their management are described. Development of this rare complication may be related to large shunt flow and long...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80188-6

    authors: Scott WC,Zhao HX,Allen M,Kim D,Miller DC

    更新日期:1984-05-01 00:00:00

  • Family history of severe cardiovascular disease in Marfan syndrome is associated with increased aortic diameter and decreased survival.

    abstract:OBJECTIVES:We attempted to determine whether a family history of severe cardiovascular disease in patients with the Marfan syndrome is associated with increased aortic dilation or decreased survival, or both. BACKGROUND:The prognostic importance of a family history of severe cardiovascular disease in patients with the...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(95)00258-0

    authors: Silverman DI,Gray J,Roman MJ,Bridges A,Burton K,Boxer M,Devereux RB,Tsipouras P

    更新日期:1995-10-01 00:00:00

  • Effects of Statins on Memory, Cognition, and Brain Volume in the Elderly.

    abstract:BACKGROUND:There is widespread consumer concern that statin use may be associated with impaired memory and cognitive decline. OBJECTIVES:This study sought to examine the association between statin use and changes in memory and global cognition in the elderly population over 6 years and brain volumes over 2 years. Inte...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2019.09.041

    authors: Samaras K,Makkar SR,Crawford JD,Kochan NA,Slavin MJ,Wen W,Trollor JN,Brodaty H,Sachdev PS

    更新日期:2019-11-26 00:00:00

  • Mechanisms of early death despite thrombolytic therapy: experience from the Thrombolysis in Myocardial Infarction Phase II (TIMI II) study.

    abstract::Mechanisms of death among patients who died within 18 h of enrollment in the Thrombolysis in Myocardial Infarction Phase II (TIMI II) study were analyzed. Of 3,339 patients enrolled, 32 died within the 1st 4 h and 31 died within the subsequent 14 h. Thirteen of the 63 patients had shock at enrollment; 22 had advanced ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/0735-1097(92)90313-c

    authors: Kleiman NS,Terrin M,Mueller H,Chaitman B,Roberts R,Knatterud GL,Solomon R,McMahon RP,Braunwald E

    更新日期:1992-05-01 00:00:00

  • Recommendations for training in vascular medicine. American College of Cardiology Peripheral Vascular Disease Committee.

    abstract::Each trainee in vascular medicine must be eligible for the board certification examination of the American Board of Internal Medicine or its equivalent. Training faculty, preferably at least two members, should meet the qualifications and training requirements described in this report. They must be dedicated, effectiv...

    journal_title:Journal of the American College of Cardiology

    pub_type: 指南,杂志文章

    doi:10.1016/0735-1097(93)90077-e

    authors: Spittell JA Jr,Nanda NC,Creager MA,Ochsner JL,Dorros G,Wexler L,Isner JM,Young JR

    更新日期:1993-08-01 00:00:00

  • A prospective case-control study of antibodies to coxsackie B virus in idiopathic dilated cardiomyopathy.

    abstract:OBJECTIVES:This study was conducted to determine the frequency and significance of Coxsackie B virus-specific immunoglobulin-M (IgM) in patients with idiopathic dilated cardiomyopathy and compare them with the frequency in both unmatched and matched control subjects. BACKGROUND:The principal evidence supporting a path...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90742-0

    authors: Keeling PJ,Lukaszyk A,Poloniecki J,Caforio AL,Davies MJ,Booth JC,McKenna WJ

    更新日期:1994-03-01 00:00:00

  • Intravascular stents in congenital heart disease: short- and long-term results from a large single-center experience.

    abstract:OBJECTIVES:This report describes the results of the Food and Drug Administration's phase 1 and 2 clinical trials of intravascular stents at Texas Children's Hospital. BACKGROUND:Since the late 1980s, intravascular stent implantation for the treatment of arterial and venous stenoses in congenital heart disease has been...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(97)00535-4

    authors: Shaffer KM,Mullins CE,Grifka RG,O'Laughlin MP,McMahon W,Ing FF,Nihill MR

    更新日期:1998-03-01 00:00:00

  • Impact of Pre-Procedural Blood Pressure on Long-Term Outcomes Following Percutaneous Coronary Intervention.

    abstract:BACKGROUND:High systolic blood pressure (SBP) increases cardiac afterload, whereas low diastolic blood pressure (DBP) may lead to impaired coronary perfusion. Thus, wide pulse pressure (high systolic, low diastolic [HSLD]) may contribute to myocardial ischemia and also be a predictor of adverse cardiovascular events. ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2019.03.493

    authors: Warren J,Nanayakkara S,Andrianopoulos N,Brennan A,Dinh D,Yudi M,Clark D,Ajani AE,Reid CM,Selkrig L,Shaw J,Hiew C,Freeman M,Kaye D,Kingwell BA,Dart AM,Duffy SJ,Melbourne Interventional Group Investigators.

    更新日期:2019-06-11 00:00:00

  • Independent and incremental value of coronary artery calcium for predicting the extent of angiographic coronary artery disease: comparison with cardiac risk factors and radionuclide perfusion imaging.

    abstract:OBJECTIVES:The study was done to test the ability to predict the extent of angiographically determined coronary artery disease (CAD) by quantification of coronary calcium using electron-beam computed tomography (EBCT) and to compare it with more conventional parameters for delineating the angiographic extent of CAD, th...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(99)00265-x

    authors: Schmermund A,Denktas AE,Rumberger JA,Christian TF,Sheedy PF 2nd,Bailey KR,Schwartz RS

    更新日期:1999-09-01 00:00:00

  • Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation: A Nationwide Cohort Study From Taiwan.

    abstract:BACKGROUND:Recent studies from Asia have suggested that the risk of ischemic stroke for patients with atrial fibrillation (AF) with a "low-risk" congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65 to 74, female (CHA2DS2-VASc) score of 0...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2015.07.026

    authors: Chao TF,Wang KL,Liu CJ,Lin YJ,Chang SL,Lo LW,Hu YF,Tuan TC,Chung FP,Liao JN,Chen TJ,Chiang CE,Lip GY,Chen SA

    更新日期:2015-09-22 00:00:00

  • Cardiac magnetic resonance predicts outcome in patients with premature ventricular complexes of left bundle branch block morphology.

    abstract:OBJECTIVES:We investigated whether the presence of right ventricular (RV) abnormalities detected by cardiovascular magnetic resonance (CMR) predict adverse outcome in patients presenting with frequent premature ventricular complexes (PVCs) of left bundle branch block (LBBB) morphology. BACKGROUND:CMR is a component of...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2010.03.087

    authors: Aquaro GD,Pingitore A,Strata E,Di Bella G,Molinaro S,Lombardi M

    更新日期:2010-10-05 00:00:00