Abstract:
OBJECTIVES:We tested whether mibefradil, a selective T-type calcium channel blocking agent, could differentially inhibit experimental ventricular arrhythmogenesis more than contractility during acute regional ischemia and reperfusion compared with that during L-channel blockade by verapamil. BACKGROUND:T-type calcium channels are found in nodal and conduction tissue and in vascular smooth muscle, but in much lower density in contractile myocardium. The potential role of mibefradil in ventricular arrhythmogenesis remains unclear. METHODS:Mibefradil (Ro 40-5967, 1 mg/kg body weight intravenously [i.v.]) was given as a bolus 30 min before anterior descending coronary artery ligation, followed by 2 mg/kg per h i.v. during 20 min of ischemia and 25 min of reperfusion in open chest pigs. In a second group, mibefradil was given in a dose twice as high. A third group received verapamil (0.3 mg/kg i.v.), followed by an infusion of 0.6 mg/kg per h. RESULTS:During the ischemic period, the low (clinically relevant) dose of mibefradil prevented the fall of the ventricular fibrillation threshold, without depressing the maximal rate of pressure development of the left ventricle (LVmax dP/dt). This low dose increased left ventricular blood flow, whereas peripheral arterial pressure remained unchanged. The higher dose of both mibefradil and verapamil was antiarrhythmic during ischemia, at the cost of depressed contractile activity. During reperfusion, only the higher dose of mibefradil and verapamil was antiarrhythmic but both depressed contractile activity. CONCLUSIONS:Mibefradil is antiarrhythmic, without inotropic compromise. Speculatively, both T-type and L-type calcium channel blockade are involved in these effects.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Muller CA,Opie LH,McCarthy J,Hofmann D,Pineda CA,Peisach Mdoi
10.1016/s0735-1097(98)00182-xsubject
Has Abstractpub_date
1998-07-01 00:00:00pages
268-74issue
1eissn
0735-1097issn
1558-3597pii
S0735-1097(98)00182-Xjournal_volume
32pub_type
杂志文章abstract:OBJECTIVES:We investigated whether a higher serum erythropoietin (EPO) level in patients with acute myocardial infarction (MI) subjected to successful primary percutaneous coronary intervention (PCI) can predict a smaller infarct size determined by creatine kinase (CK) release. BACKGROUND:Erythropoietin has been shown...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2005.01.043
更新日期:2005-05-03 00:00:00
abstract::Certain clinical and cardiac morphologic findings are described in 22 patients, aged 45 to 80 years (mean 64) (15 men [68%]), in whom rupture of a papillary muscle occurred during acute myocardial infarction. In most, the acute infarction associated with papillary muscle rupture was a first coronary event (only 18% ha...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(86)80182-6
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更新日期:1997-11-15 00:00:00
abstract:OBJECTIVES:The aim of the study was to compare the diagnostic yield and the costs of implantable loop recorder (ILR) with those of the conventional strategy in patients with unexplained palpitations. BACKGROUND:In patients with unexplained palpitations, especially in those with infrequent symptoms, the conventional st...
journal_title:Journal of the American College of Cardiology
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更新日期:2007-05-15 00:00:00
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doi:10.1016/0735-1097(92)90376-x
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更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether the release of nitric oxide (NO) from the ischemic heart increases during exercise in patients with effort angina. BACKGROUND:Myocardial ischemia increases NO production in the canine heart, but no such increase has been demonstrated in the ischemic human heart...
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abstract::Patients with diabetes mellitus experience a more adverse outcome after acute myocardial infarction compared with nondiabetic patients, although the mechanisms responsible for these findings are not clear. From the Multicenter Investigation of the Limitation of Infarct Size (MILIS) study, the course of acute infarctio...
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更新日期:2021-01-05 00:00:00
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更新日期:2004-08-04 00:00:00
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doi:10.1016/s0735-1097(98)00054-0
更新日期:1998-04-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2017.05.043
更新日期:2017-07-11 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-03-13 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2013-09-10 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:2002-08-21 00:00:00
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更新日期:1994-07-01 00:00:00
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更新日期:2006-05-02 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(87)80467-9
更新日期:1987-06-01 00:00:00
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更新日期:1991-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2020-03-24 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jacc.2017.06.054
更新日期:2017-08-22 00:00:00