Abstract:
OBJECTIVES:The purpose of this research was to determine the levels of platelet, leukocyte, and endothelial activation and markers of cellular interactions in patients with venous thromboembolism (VTE). BACKGROUND:The details of interactions between endothelium, platelets, and leukocytes in VTE are not well understood. METHODS:We studied 25 patients with VTE and compared 25 healthy controls. We used flow cytometry to measure: 1) endothelial microparticles (EMP) identified by CD31+/CD42b- (EMP(31)) or E-selectin (EMP(62E)); 2) platelet microparticles (CD31+/CD42b+); 3) surface expression of P-selectin in platelets and CD11b in leukocytes; 4) EMP-monocyte conjugates (percentage of monocytes positive for E-selectin); and 5) platelet-leukocyte conjugates (PLC) expressed as percentage of leukocytes positive for CD41. RESULTS:Patients with VTE had marked elevations of EMP(31) (2,193 vs. 383 counts/microl; p = 0.003), EMP(62E) (368 vs. 223 counts/microl; p = 0.001), and EMP-monocyte conjugates (3.3% vs. 2.5%; p = 0.002), as well as increased activation of platelets (35.2 vs. 5.0 fluorescence intensity units for P-selectin; p < 0.0001) and leukocytes (13.9 vs. 7.7 U for CD11b; p = 0.004). Also elevated in VTE were PLC (61.7% vs. 39.6%; p = 0.01). Expression of CD11b in leukocytes strongly correlated with PLC (r = 0.74; p < 0.0001). CONCLUSIONS:Marked activation of endothelium, platelets, and leukocytes occurs in VTE, and VTE, or the accompanying inflammatory process, involves the release of EMP and formation of EMP-monocyte conjugates and PLC. These findings support prior studies suggesting that release of EMP and their binding to monocytes are key events in thrombogenesis. Our findings also support the concept that the formation of PLC regulates leukocyte activation and participates in linking thrombosis with inflammation.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Chirinos JA,Heresi GA,Velasquez H,Jy W,Jimenez JJ,Ahn E,Horstman LL,Soriano AO,Zambrano JP,Ahn YSdoi
10.1016/j.jacc.2004.12.075subject
Has Abstractpub_date
2005-05-03 00:00:00pages
1467-71issue
9eissn
0735-1097issn
1558-3597pii
S0735-1097(05)00369-4journal_volume
45pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to confirm clinically a hypothesis that cilostazol inhibits leukocyte Mac-1, leading to prevention of post-stent restenosis. BACKGROUND:The platelet phosphodiesterase III inhibitor called cilostazol also inhibits alpha-granule release of P-selectin in platelets. The P-selectin-medi...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jacc.2004.06.066
更新日期:2004-10-06 00:00:00
abstract:OBJECTIVES:This study tested the hypothesis that response to antiarrhythmic drugs (AADs) is modulated by 3 common loci associated with atrial fibrillation (AF). BACKGROUND:Recent genome-wide association studies have identified 3 loci, on chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), that associ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2012.01.070
更新日期:2012-08-07 00:00:00
abstract::The mechanism of electrocardiographic ST segment changes during acute coronary occlusion was evaluated in 28 consecutive patients with single vessel coronary artery disease undergoing coronary angioplasty. Patients were continuously monitored with a six lead electrocardiogram. Twenty-three patients showed ST changes i...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(85)80250-3
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abstract:OBJECTIVES:This study sought to determine the long-term outcome of adult patients undergoing percutaneous balloon aortic valvuloplasty. BACKGROUND:Percutaneous balloon aortic valvuloplasty has been offered as an alternative to aortic valve replacement for selected patients with valvular aortic stenosis. Although ballo...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(95)00363-0
更新日期:1995-11-15 00:00:00
abstract::To test the value of acceleration flow signals proximal to the leaking orifice in assessing the severity of prosthetic mitral valve regurgitation, 39 consecutive patients undergoing left ventriculography were examined by Doppler color flow imaging. Acceleration flow signals proximal to the regurgitant orifice were det...
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doi:10.1016/0735-1097(92)90487-8
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abstract:OBJECTIVES:Apoptosis develops in several heart diseases, but the therapeutic options are limited. It was hypothesized that nicotine, which inhibits apoptosis in several cells, inhibits cardiac apoptosis induced by lipopolysaccharide (LPS). BACKGROUND:Over-the-counter nicotine produces sustained levels (10 to 25 ng/ml)...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(02)02820-6
更新日期:2003-02-05 00:00:00
abstract::The efficacy and safety of oral nadolol in supraventricular tachycardia were evaluated prospectively in 27 children (median age 5.5 years). Fifteen patients had an unsuccessful trial of digoxin therapy. Intravenous nadolol was given to seven patients during electrophysiologic study; five of these had an excellent resp...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:1992-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0735-1097(93)90791-x
更新日期:1993-12-01 00:00:00
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更新日期:2012-08-14 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2005-07-19 00:00:00
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doi:10.1016/s0735-1097(97)00535-4
更新日期:1998-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2005.11.012
更新日期:2006-02-07 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(03)01059-3
更新日期:2003-10-15 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jacc.2016.03.529
更新日期:2016-06-14 00:00:00
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更新日期:2008-03-04 00:00:00
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更新日期:2018-06-12 00:00:00
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更新日期:2010-07-27 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-05 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(01)01266-9
更新日期:2001-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1988-07-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2011.08.082
更新日期:2012-03-20 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
abstract::The patient with heart disease and the physician providing cardiovascular health care have experienced dramatic change since the American College of Cardiology first published its journal 25 years ago. During the decade before 1958, cardiology and cardiovascular surgery emerged as specialties. Surgery by closed techni...
journal_title:Journal of the American College of Cardiology
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更新日期:1983-01-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00