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Challenges in the Design and Interpretation of Noninferiority Trials: Insights From Recent Stent Trials.

Abstract：

:The noninferiority design is used extensively in current clinical research, but its complex features may hamper the appropriate interpretation of such trials. Thus, understanding the pillars of noninferiority design is indispensable. The authors discuss fundamental concepts regarding the design and interpretation of noninferiority trials and then explore some common methodological criticism by analyzing a sample of contemporary coronary stent trials. Finally, the authors give an overall perspective to enhance the design and conduct of future trials.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Macaya F,Ryan N,Salinas P,Pocock SJ

doi

10.1016/j.jacc.2017.06.039

subject

Has Abstract

pub_date

2017-08-15 00:00:00

pages

894-903

issue

7

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(17)37927-5

journal_volume

70

pub_type

杂志文章,评审

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