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In vitro activity of linezolid as assessed through the 2013 LEADER surveillance program.

Abstract：

:The 2013 LEADER surveillance program monitored the in vitro activity of linezolid and comparator agents against Gram-positive bacteria at 60 medical centers in the United States. A total of 7183 pathogens were contributed from 6 predetermined pathogen groups. The groups were Staphylococcus aureus, coagulase-negative staphylococci, enterococci, Streptococcus pneumoniae, β-hemolytic streptococci, and viridans group streptococci. The MIC90 value for each of the 6 pathogen groups was 1 μg/mL. Susceptibility of "all organisms" to linezolid was 99.83%. Only 12 isolates (2 S. aureus, 3 Staphylococcus epidermidis, 1 Streptococcus sanguinis, 5 Enterococcus faecium, and 1 Enterococcus faecalis) were nonsusceptible to linezolid (0.17%). Three of these (2 S. aureus and 1 E. faecium) harbored the cfr resistance mechanism. The findings indicate that linezolid activity remains stable, although there are examples of clonal dissemination within several monitored institutions.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Flamm RK,Mendes RE,Hogan PA,Ross JE,Farrell DJ,Jones RN

doi

10.1016/j.diagmicrobio.2014.12.009

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

283-9

issue

4

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(14)00519-7

journal_volume

81

pub_type

杂志文章

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