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Relevance of autoantibody detection to the rapid diagnosis of brucellosis.

Abstract：

:The rose bengal test is often used for rapid diagnosis of human brucellosis in endemic areas. However, autoantibodies have never been investigated as a reason for false-positive or false-negative results. Therefore, the aim of this study was to show the effect of autoantibody detection on the rapid diagnosis of human brucellosis in an endemic area. The study included 2 groups: antinuclear antibody (ANA)-positive and ANA-negative groups. Diagnosis of brucellosis was established by isolation of Brucella spp. from blood culture. The overall sensitivity and specificity of the rose bengal test were 100% and 90.8%, respectively. The specificity (100% versus 89%) and positive predictive value of the test (100% versus 8%) fell markedly from the ANA-negative to the ANA-positive group. As a conclusion, this study verified our suspicion about the effect of autoantibodies on rose bengal test results to the diagnosis of human brucellosis. However, to have definite decisions, extensive studies with larger populations are needed.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Yumuk Z,Afacan G,Calişkan S,Irvem A,Arslan U

doi

10.1016/j.diagmicrobio.2007.01.003

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

271-3

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(07)00027-2

journal_volume

58

pub_type

杂志文章

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