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Changes in the balance between Treg and Th17 cells in patients with chronic hepatitis B.

Abstract：

:The purpose of this study was to explore the role of Treg cells, Th17 cells and cytokines associated with Treg/Th17 differentiation in the occurrence, development and outcome of chronic hepatitis B (CHB). To do so, we detected populations of Treg and Th17 cells and their associated cytokines in the peripheral blood of CHB patients. The populations of Treg cells (CD4(+)CD25(high)CD127(low) T cells) and Th17 cells (CD3(+)CD8(-)IL-17(+) T cells) were analyzed in 46 patients with low to moderate chronic hepatitis B (CHB-LM), 24 patients with severe chronic hepatitis B (CHB-S) and 20 healthy controls (HC) using flow cytometry. The levels of cytokines associated with Treg/Th17 differentiation, including IL-10, TGF-β1, IL-17 and IL-23, were measured by enzyme-linked immunosorbent assay (ELISA). Our study showed that the imbalance of Treg and Th17 cells might play an important role in the occurrence, development and outcome of CHB.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Su ZJ,Yu XP,Guo RY,Ming DS,Huang LY,Su ML,Deng Y,Lin ZZ

doi

10.1016/j.diagmicrobio.2013.04.026

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

437-44

issue

4

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(13)00265-4

journal_volume

76

pub_type

杂志文章

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