Abstract:
:Radiation pneumonitis (RP) is a common complication for radiotherapy of esophageal cancer and is associated with the low dose irradiated lung volume. This study aims to reduce the mean lung dose (MLD) and the relative lung volume at 20 Gy (V 20) and at low dose region using various designs of the fan-shaped complete block (FSCB) in helical tomotherapy. Hypothetical esophageal tumor was delineated on an anthropomorphic phantom. The FSCB was defined as the fan-shaped radiation restricted area located in both lungs. Seven treatment plans were performed with nonblock design and FSCB with different fan angles, that is, from 90° to 140°, with increment of 10°. The homogeneous index, conformation number, MLD, and the relative lung volume receiving more than 5, 10, 15, and 20 Gy (V 5, V 10, V 15, and V 20) were determined for each treatment scheme. There was a substantial reduction in the MLD, V 5, V 10, V 15, and V 20 when using different types of FSCB as compared to the nonblock design. The reduction of V 20, V 15, V 10, and V 5 was 6.3%-8.6%, 16%-23%, 42%-57%, and 42%-66% for FSCB 90°-140°, respectively. The use of FSCB in helical tomotherapy is a promising method to reduce the MLD, V 20, and relative lung volume in low dose region, especially in V 5 and V 10 for esophageal cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chang CH,Mok GS,Shueng PW,Yeh HP,Shiau AC,Tien HJ,Lin CT,Wu THdoi
10.1155/2015/959504subject
Has Abstractpub_date
2015-01-01 00:00:00pages
959504eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract::Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autophagy in neurodegene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6701793
更新日期:2016-01-01 00:00:00
abstract::Both human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been explored as attractive mesenchymal stem cells (MSCs) sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative st...
journal_title:BioMed research international
pub_type: 杂志文章,收录出版
doi:10.1155/2013/438243
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/783698
更新日期:2013-01-01 00:00:00
abstract::To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/419376
更新日期:2014-01-01 00:00:00
abstract::In vitro research performed on eukaryotic or prokaryotic cell cultures usually represents the initial step for characterization of a novel photosensitizer (PS) intended for application in photodynamic therapy (PDT) of cancer or photodynamic inactivation (PDI) of microorganisms. Although many experimental steps of PS t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/840417
更新日期:2013-01-01 00:00:00
abstract:Background:Antiretroviral therapy transformed HIV infection into a chronic disease but accelerated cardiovascular disease (CVD). Both of epicardial adipose tissue (EAT) and pericardial fat (PCF) have close relationships with CVD. The associations between these two cardiac adipose tissue and HIV are unclear. Methods:El...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/8234618
更新日期:2020-12-09 00:00:00
abstract::Salinity is a major environmental stress that limits crop production worldwide. In this study, we characterized plant growth-promoting rhizobacteria (PGPR) containing 1-aminocyclopropane-1-carboxylate (ACC) deaminase and examined their effect on salinity stress tolerance in okra through the induction of ROS-scavenging...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6284547
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Noninvasive tools to diagnose nonalcoholic fatty liver disease (NAFLD), including transient elastography (TE) and enhanced liver fibrosis panel (ELF), have only been evaluated in children with biopsy-proven NAFLD. We evaluated the prevalence of ELF and TE abnormalities in obese children without clinical live...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/457473
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Long-term survival of total knee arthroplasty (TKA) is mainly determined by optimal positioning of the components and prosthesis alignment. Implant positioning can be optimized by computer assisted surgery (CAS). Patient specific cutting blocks (PSCB) seem to have the potential to improve component alignment...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/562919
更新日期:2014-01-01 00:00:00
abstract::Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4375075
更新日期:2020-11-14 00:00:00
abstract:Background:The predictive values of monocytes in the prognosis of patients with acute paraquat (PQ) poisoning are unclear. This retrospective study investigated the predictive values of monocytes in the prognosis of patients with acute PQ poisoning. Methods:Adult patients who suffered from acute PQ poisoning in the em...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/6360459
更新日期:2019-07-15 00:00:00
abstract::Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn disease (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of genes during the inflammation and thus co...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4250329
更新日期:2020-07-22 00:00:00
abstract:Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8676343
更新日期:2020-05-21 00:00:00
abstract::Lung cancer consists of two main subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In this study, we have developed a network-based approach to identify molecular biomarkers that can distinguish SCLC from NSCLC. By identifyin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/685303
更新日期:2015-01-01 00:00:00
abstract::Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death. In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis. Recently, antioxidan...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/680615
更新日期:2015-01-01 00:00:00
abstract::Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular function...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/413708
更新日期:2014-01-01 00:00:00
abstract::The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controve...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3571861
更新日期:2017-01-01 00:00:00
abstract::Stimuli responsive pH- and temperature-sensitive hydrogel drug delivery systems, as those based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), have been attracting much of the attention of the scientific community nowadays, especially in the field of drug release. By adjusting comonomer composition, the mat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/364930
更新日期:2014-01-01 00:00:00
abstract::This study evaluated the efficacy and safety of pulmonary rehabilitation (PR) for pneumoconiosis. We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, SinoMed, CNKI, VIP databases and Wanfang Data from their inception to June 1, 2019. A systematic review and meta-analysis of randomized cont...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6174936
更新日期:2020-07-28 00:00:00
abstract::A bioenergetical analysis of swimming at intensities near competitive distances is inexistent. It was aimed to compare the transient VO2 kinetics responses and metabolic contributions whilst swimming at different velocities around VO2max. 12 trained male swimmers performed (i) an incremental protocol to determine the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/675363
更新日期:2014-01-01 00:00:00
abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8751384
更新日期:2017-01-01 00:00:00
abstract::Schistosomiasis is one of the world's major public health problems. Praziquantel is currently the only effective drug against schistosomiasis. As resistance of praziquantel has emerged in some endemic areas, development of new antischistosomal agents should be a high priority. In this study, a phage display peptide li...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9483928
更新日期:2018-06-05 00:00:00
abstract::Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/845032
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/714230.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2016/9325260
更新日期:2016-01-01 00:00:00
abstract::Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
abstract::Although triacylglycerol, the major component for lipid storage, is essential for normal physiology, its excessive accumulation causes obesity in adipose tissue and is associated with organ dysfunction in nonadipose tissue. Here, we focused on the Drosophila model to develop therapeutics for preventing obesity. The br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6293163
更新日期:2016-01-01 00:00:00
abstract:Background:Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology:A cross-sectional study was conducted to assess the practice of diagnosis and treatment of salmonellosis in Addis Aba...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6406405
更新日期:2018-05-23 00:00:00
abstract:Objective:To evaluate the performance of contrast-enhanced mammography (CEM) compared to magnetic resonance imaging (MRI) for estimating residual tumor size after neoadjuvant chemotherapy (NAC) in women with newly diagnosed breast cancer. Methods:The institutional review board approved this study. This prospective stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8531916
更新日期:2018-11-08 00:00:00
abstract::Protein phosphorylation is catalyzed by kinases which regulate many aspects that control death, movement, and cell growth. Identification of the phosphorylation site-specific kinase-substrate relationships (ssKSRs) is important for understanding cellular dynamics and provides a fundamental basis for further disease-re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1826496
更新日期:2017-01-01 00:00:00
abstract::Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/6040379
更新日期:2016-01-01 00:00:00