[Mechanical circulatory support saves lives -- three years' experience of the newly established assist device program at Semmelweis University, Budapest, Hungary].

Abstract:

INTRODUCTION:Since the celebration of the 20th anniversary of the first heart transplantation in Hungary in 2012 the emerging need for modern heart failure management via mechanical circulatory support has evolved. In May 2012 the opening of a new heart failure and transplant unit with 9 beds together with the procurement of necessary devices at Semmelweis University accomplished this need. AIM:The aim of the authors was to report their initial experience obtained in this new cardiac assist device program. METHOD:Since May, 2012, mechanical circulatory support system was applied in 89 cases in 72 patients. Indication for support were end stage heart failure refractory to medical treatment and acute left or right heart failure. RESULTS:Treatment was initiated for acute graft failure after heart transplantation in 27 cases, for end stage heart failure in 24 cases, for acute myocardial infarction in 21 cases, for acute postcardiotomy heart failure in 14 cases, for severe respiratory insufficiency in 2 cases and for drug intoxication in one case. Among the 30 survivor of the whole program 13 patients were successfully transplanted. CONCLUSIONS:The available devices can cover all modalities of current bridge therapy from short term support through medium support to heart transplantation or long term support and destination therapy. These conditions made possible the successful start of a new cardiac assist device program. :Bevezetés: Magyarországon 2012-ben ünnepelte 20 éves évfordulóját a szívtranszplantáció, ám a mechanikus keringéstámogató eszközök ezalatt az idő alatt a végstádiumú szívelégtelenség korszerű terápiájának hiányzó láncszemét alkották. 2012 májusában, a Semmelweis Egyetem Szív- és Érgyógyászati Klinikáján átadott szívtranszplantációs és szívelégtelenség intenzív osztály, valamint az ehhez társuló eszközfejlesztések tették lehetővé a műszívprogram elindulását. Célkitűzés: A szerzők a program tapasztalatairól számolnak be. Módszer: 2012 májusa és 2014 decembere között 72 beteget 89 esetben kezeltek mechanikus keringéstámogató eszközökkel. A támogatás indikációja valamennyi esetben terápiarefrakter végstádiumú szívelégtelenség, illetve akut bal- vagy jobbszívfél-elégtelenség volt. Eredmények: Huszonhét esetben szívtranszplantáció utáni akut graftelégtelenség, 24 esetben súlyos végstádiumú szívelégtelenség, 21 esetben akut infarktus, 14 esetben szívműtét utáni akut balszívfél-elégtelenség, két esetben súlyos légzési elégtelenség, egy esetben gyógyszermérgezés következtében kialakult malignus ritmuszavar miatt kezdték el a terápiát. A teljes program 30 túlélő betege közül 13 került sikeres szívtranszplantációra. Következtetések: A rendelkezésre álló sokoldalú műszerparkkal a ma létező valamennyi lehetséges terápiás modalitás megvalósítható a rövid távú keringéstámogatástól a középtávú támogatáson át a szívtranszplantációig vagy a végleges műszívbeültetésig. Orv. Hetil., 2015, 156(13), 521–527.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Fazekas L,Sax B,Hartyánszky I,Pólos M,Horkay F,Varga T,Rácz K,Németh E,Székely A,Paulovich E,Heltai K,Zima E,Szabolcs Z,Merkely B

doi

10.1556/OH.2015.30115

subject

Has Abstract

pub_date

2015-03-29 00:00:00

pages

521-7

issue

13

eissn

0030-6002

issn

1788-6120

pii

807388U251140873

journal_volume

156

pub_type

杂志文章
  • [Gastric and duodenal intramural hematoma: report of two cases].

    abstract::Two cases of intramural hematoma arising in the duodenum and the stomach are reported. Both patients were male, aged 40 and 58 years, and suffered from chronic pancreatitis. Hematoma of the duodenal wall may have resulted from the acute exacerbation of the chronic pancreatitis in the first patient. As to the second ca...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Dibuz M,Szabó T,Monoki E,Nagymélykuti L,Illyés M,Varga E,Csípö L

    更新日期:1998-12-06 00:00:00

  • [De Quervain thyroiditis. Corner points of the diagnosis].

    abstract::Inflammatory disorders of the thyroid gland are divided into three groups according to their duration (acute, subacute and chronic). De Quervain's thyroiditis (also termed giant cell or granulomatous thyroiditis) is a subacute inflammation of the thyroid, which accounts for 5% of thyroid disorders. The etiology is unk...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2014.29865

    authors: Oláh R,Hajós P,Soós Z,Winkler G

    更新日期:2014-04-27 00:00:00

  • [Granulomatous hepatitis successfully treated with ursodeoxycholic acid].

    abstract::The etiology of granulomatous hepatitis is extremely extensive for which the granulomatous reaction induced hepatic inflammation is characteristic. In the majority of cases it is part of a systemic disease but sometimes there is primer hepatic lesion in the background. The 21 year-old Caucasian female patient was take...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Németh E,Bugovics E,Lengyel G,Pécsi G,Schaff Z,Fehér J

    更新日期:2006-08-06 00:00:00

  • [The importance of the doctor-patient communication in the care of somatizing patients].

    abstract::The term "somatization" refers to the manifestation of multiple somatic complaints not explained by organic changes. According to the literature, 15-25 percent of all medical visits are related to somatization. As medical training does not put enough emphasis on the evaluation of the possible psychological background ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2016.30453

    authors: Stauder A,Eörsi D,Pilling J

    更新日期:2016-04-24 00:00:00

  • Effect of the surgical exposure on the early postoperative period after total knee arthroplasty

    abstract:INTRODUCTION:Total knee arthroplasty has become one of the most successful and safest surgical procedures in orthopedic surgery. Of the many different types of surgical exposure, the most common, so-called medial parapatellar (MP) incision is the cut of the quadriceps tendon, which impairs extensor function. In contras...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2020.31774

    authors: Bejek Z,Holnapy G,Skaliczki G,Stubnya B,Szatmári A

    更新日期:2020-07-01 00:00:00

  • [Sjögren's syndrome and multiple myeloma].

    abstract::In our recent work we present two cases of coexisting Sjögren's syndrome and myeloma multiplex. Our results obtained studying a high number of patients suggest that the occurrence of myeloma in Sjögren's syndrome is much higher than in normal population. This can possibly be explained by the common pathogenetical fact...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gál I,Zeher M

    更新日期:2000-09-17 00:00:00

  • [Evaluation of the teratogenic effects of occupational hazards during pregnancy].

    abstract::The Hungarian Case-Control Surveillance System of Congenital Anomalies, 1980-1987 contains 10,937 index patients affected by congenital anomalies and 10,937 matched control cases. Their comparative analysis indicated a significantly higher rate of some congenital anomaly types in the offspring of women worked in agric...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Király J,Czeizel E

    更新日期:1990-05-27 00:00:00

  • [Polymyositis-dermatomyositis recognized during the follow-up of a patient with type 2 diabetes].

    abstract::Polymyositis-dermatomyositis is a rare systemic autoimmune disease which belongs to the class of idiopathic inflammatory myopathies. The disease exhibits high inter-individual variability, but chronic myositis is a common feature. As different manifestations often appear in atypical forms, establishing the precise dia...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2012.29300

    authors: Samer F,Csóka M,Dankó K

    更新日期:2012-03-25 00:00:00

  • [Psychological factors of successful kidney transplantations. The effects of anxiety and intrapsychic integration of the organ on recovery].

    abstract:UNLABELLED:Transplant patients' attitudes and representations related to their illness, their body, and the healing process have a significant impact on their recovery. AIMS:The study involved 51 patients from the Department of Surgery, University of Szeged, Hungary. The primary aim was to examine the possible connect...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2012.29327

    authors: Látos M,Barabás K,Lázár G,Marofka F,Szederkényi E,Szenohradszky P,Csabai M

    更新日期:2012-04-15 00:00:00

  • [First decade of post-genomic era. Hopes, disappointments, new answers].

    abstract::The first decade after the announcement of the draft sequence of human genome has brought spectacular advances in basic science, however, the fact that human health did not benefit that much caused disappointment, as well. In order to explore the causes of the absence of revolution in medicine, beside the extension of...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2010.29014

    authors: Kosztolányi G

    更新日期:2010-12-19 00:00:00

  • Importance of the imaging techniques in the management of COVID-19-infected patients

    abstract::Critical-care physicians are facing a challenging process in healthcare due to the overwhelming case number of hypoxic respiratory failure patients. Pneumonia has an utmost importance in the primary pathomechanism of the development of critical illness in the COVID-19 patients. Thus, imaging techniques are situated in...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2020.31814

    authors: Lovas A,Hankovszky P,Korsós A,Kupcsulik S,Molnár T,Szabó Z,Babik B

    更新日期:2020-04-01 00:00:00

  • [Diagnostic value of tumor markers in ENT oncology].

    abstract::Control serum samples of young, healthy volunteers (N = 5) were compared with serum samples and laryngeal cancer extracts of patients (N = 12) with stage 3 and 4 cancers. Eight patients were primarily treated by total laryngectomy, 4 patient by palliative irradiation therapy (60 Gy). Ethanol (80%, pH 2) extracts of se...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章

    doi:

    authors: Tamás L,Sziklai I,Ribári O

    更新日期:1997-05-18 00:00:00

  • [Evaluation of survival in mixed connective tissue disease (MCTD)].

    abstract:INTRODUCTION:179 patients with mixed connective tissue disease (MCTD) were follow-up, and the cause of death was analyzed in 12 died patients. PATIENTS AND METHODS:The survival of 179 patients with MCTD was evaluated by using Kaplan-Meier's method. Clinically and immunological data of the patients were analyzed betwee...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Bodolay E,Gaál J,Végh J,Soltész P,Szodoray P,Lakos G,Nemes Z,Dezsö B,Szegedi G

    更新日期:2002-11-10 00:00:00

  • [The bone-marrow transplantation program in Hungary: report from the period 1990-1995].

    abstract::The article summarises the statistical data of bone marrow transplantation (BMT) carried out in Hungary between 1990-1995 in yearly distribution. Since the first BMT up to the end of 1995, 168 BMT were performed. The number of transplantations since 1990 to our days was gradually increasing. As a result of this activi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Petrányi G,Masszi T,Tímár L,Kriván G,Pálóczi K,Nagy K,Fekete S,Reményi P,Torbágyi E,Dénes R,Kelemen E

    更新日期:1996-10-06 00:00:00

  • [Epidemiology, risk factors and molecular pathogenesis of primary liver cancer].

    abstract::Primary liver cancer is the fifth most common cancer worldwide. Hepatocellular carcinoma accounts for 85-90% of primary liver cancers. Distribution of hepatocellular carcinoma shows variations among geographic regions and ethnic groups. Males have higher liver cancer rates than females. Hepatocellular carcinoma occurs...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2008.28313

    authors: Hagymási K,Tulassay Z

    更新日期:2008-03-23 00:00:00

  • [Effect of ACE gene polymorphism on carbohydrate metabolism, on oxidative stress and on end-organ damage in type-2 diabetes mellitus].

    abstract::ACE gene insertion/deletion (I/D) polymorphism is a well-known risk factor of hypertension, cardiovascular diseases and progression of diabetic nephropathy. In carriers of allele D, serum level of angiotensin-II is higher, which can be associated with increased oxidative stress and subsequent endothelial damage. Album...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Molnár GA,Wagner Z,Wagner L,Melegh B,Kószegi T,Degrell P,Bene J,Tamaskó M,Laczy B,Nagy J,Wittmann I

    更新日期:2004-04-18 00:00:00

  • [Effect of fructose-1,6-diphosphate on myocardial purin and pyrimidin metabolism during coronary artery bypass grafting surgery].

    abstract::During ischaemia, the glycolytic pathway (Embden-Meyerhof) is up regulated in an attempt to produce ATP anaerobically. However, this is short-lived due to negative feedback on the key glycolytic enzyme phosphofructokinase by accumulating lactate. Fructose-1,6-diphosphate (FDP), a high energy intermediary metabolite of...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Gál J,Riedel BJ,Róth E,Bogár L,Tekeres M,Royston D

    更新日期:2000-09-10 00:00:00

  • [Gastrointestinal tuberculosis--an almost forgotten clinical picture].

    abstract::Incidence of gastrointestinal tuberculosis increases in the western world. Exact epidemiological data about this rare extrapulmonological disease are not available in Hungary. Three advanced cases with intestinal tuberculosis have been reported, all of them recognised during surgery due to complications. The clinicopa...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Kisfaludy N,Schneider F,Fauszt J,Faludi S

    更新日期:1998-02-01 00:00:00

  • [Ayurveda for the treatment of obesity].

    abstract::Obesity is an increasing problem all over the world as the lifestyle changes and fast food chains gain popularity. In India, 31% of men and 29% of women are overweight, which is a growing trend over the last 11 years. Obesity increases the risk of many diseases such as cardiovascular diseases, reflux disease, gastroin...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2016.30534

    authors: Korossy A,Blázovics A

    更新日期:2016-08-01 00:00:00

  • [The severity of gestational diabetes mellitus affects microvascular dysfunction measured three years after pregnancy that may be related to increased oxidative stress].

    abstract:INTRODUCTION:Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. AIM:The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2015.30307

    authors: Horváth EM,Mágenheim R,Domján BA,Ferencz V,Tänczer T,Szabó E,Benkő R,Szabó C,Tabák Á,Somogyi A

    更新日期:2015-11-22 00:00:00

  • [Intracranial pressure increase and changes in cerebrovascular circulation, associated with brain death, studied by transcranial Doppler sonography].

    abstract::Blood flow velocity of 24 patients in state of the brain death were examined by transcranial Doppler sonography. Authors expound the characteristic velocity-pulse graphs recorded in progressively increasing intracranial pressure and their chronology as well. The different forms of the oscillating flow and their succes...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Rózsa L,Szabó S,Gombi R,Mikó L,Balázs E

    更新日期:1991-12-15 00:00:00

  • [Morbidity, demography and life style of Hungarian medical doctors 25 years after graduation].

    abstract:UNLABELLED:The health status and social circumstances of medical professionals have been studied worldwide. However, there are only a few published studies pertaining to these topics in the countries of the former Eastern block. The present paper aimed at charting the state of health, the medical career path and some s...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2009.28566

    authors: Rurik I,Kalabay L

    更新日期:2009-03-22 00:00:00

  • [Possibilities of non-hormonal drug treatment of osteoporosis].

    abstract::In many countries osteoporosis is the most common metabolic bone diseases. A great deal is known about the pathophysiology and the treatment of the disease. There is a lot of treatment possibilities and many new treatments are being tested. Therapeutic agents for osteoporosis are correspondingly classified as substanc...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Szathmári M,Châtel R

    更新日期:1999-09-19 00:00:00

  • [Looking back on past decades of vaccinology].

    abstract::Author makes a survey upon the progress of vaccinology from the Jennerian times up to the modern vaccines of our ages, particularly as far as Hungary is concerned. Some pictures of the vaccinology to come are dealt with, too, e.g. genetic methods, mucosal immunization etc. Some changes in vaccinology caused by either ...

    journal_title:Orvosi hetilap

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Budai J

    更新日期:2002-10-06 00:00:00

  • [Gentamycin concentration in the milk of a mother after treatment by implantation of a Septopal chain].

    abstract::The author implanted 90 beads of Septopal into the osteomyelitic femur of a wet mother. The excretion of gentamycin in the mother's milk was continuously examined. The investigations revealed that the excretion of gentamycin with the mother's milk was so minimal that it did not signify any risk for the newborn baby. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Boda A

    更新日期:1990-10-14 00:00:00

  • [Interleukin-6 acts in different ways via soluble and membrane-bound receptors].

    abstract::Interleukin-6 is a multifunctional cytokine participating in the regulation of several immunologic and other cell-physiological phenomena. It acts via a receptor consisting of two components, that besides the ligand-specific chain also contains a second component of 130 kD (gp 130). The soluble form of the ligand-spec...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Igaz P,Tóth S,Madurka I,Falus A

    更新日期:1998-07-19 00:00:00

  • [Comparative functional outcome of reverse shoulder prostheses implanted on degenerative and oncological indications].

    abstract:INTRODUCTION:Several methods (bone graft, endoprosthesis) are used to reconstruct proximal humerus resections due to primary and metastatic tumours. One of the new procedures is the replacement of the joint surfaces and the removed proximal humerus end with reverse shoulder prosthesis, optionally supplemented with bone...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2018.31219

    authors: Szatmári A,Benedek B,Perlaky T,Szalay K,Sallai I,Skaliczki G,Szendrői M,Antal I

    更新日期:2018-11-01 00:00:00

  • [Polarized light as an epigenetic factor in inhibition of inflammation; a genome-wide expression analysis in recurrent respiratory diseases of children].

    abstract:UNLABELLED:Whole-body polarized light therapy has been primarily investigated in various clinical observations and in a few in vitro model systems. AIMS:In the present study, clinical and molecular effects of whole-body polarized light treatment on children suffering from recurrent respiratory infection were studied. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2011.29162

    authors: Falus A,Fenyo M,Eder K,Madarasi A

    更新日期:2011-09-11 00:00:00

  • [The effect of thrombocyte-derived growth factor on experimental inflammatory bowel disease].

    abstract::The role of Platelet-Derived Growth Factor (PDGF) was investigated in treatment of experimental inflammatory bowel disease (IBD) in animal models. A new model of IBD induced by the sulfhydryl (SH) alkylator iodoacetamide revealed that the most appropriate concentration of iodoacetamide is 6% given intracolonically onc...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Sándor Z,Kusstatscher S,Szeli D,Szabó S

    更新日期:1995-05-14 00:00:00

  • [Neuropeptide-containing nerve fibers in the gallbladder].

    abstract::With the use of different antisera and Avidin-Biotin-Peroxidase technique, several immunopositive nerve fibers were observed in the wall of the gallbladder of the cat. A large amount of neuropeptide Y, substance P, somatostatin, vasoactive intestinal polypeptide immunoreactive nerve fibers were found in all layers. Th...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Fehér E,Fodor M,Szentpály O,Koncz E,Fehér J

    更新日期:1993-01-24 00:00:00