[Epidemiology, risk factors and molecular pathogenesis of primary liver cancer].

Abstract:

:Primary liver cancer is the fifth most common cancer worldwide. Hepatocellular carcinoma accounts for 85-90% of primary liver cancers. Distribution of hepatocellular carcinoma shows variations among geographic regions and ethnic groups. Males have higher liver cancer rates than females. Hepatocellular carcinoma occurs within an established background of chronic liver disease and cirrhosis (70-90%). Major causes (80%) of hepatocellular carcinoma are hepatitis B, C virus infection, and aflatoxin exposition. Its development is a multistep process. We have a growing understanding on the molecular pathogenesis. Genetic and epigenetic changes activate oncogenes, inhibit tumorsuppressor genes, which result in autonomous cell proliferation. The chromosomal instability caused by telomere dysfunction, the growth-retrained environment and the alterations of the micro- and macroenvironment help the expansion of the malignant cells. Understanding the molecular mechanisms could improve the screening of patients with chronic liver disease, or cirrhosis, and the prevention as well as treatment of hepatocellular carcinoma.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Hagymási K,Tulassay Z

doi

10.1556/OH.2008.28313

subject

Has Abstract

pub_date

2008-03-23 00:00:00

pages

541-8

issue

12

eissn

0030-6002

issn

1788-6120

pii

R640002577T2638X

journal_volume

149

pub_type

杂志文章,评审
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  • [Surgical treatment of laryngocele].

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    authors: Tóth K,Fabula J

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  • [Two successful pregnancies after total thyroidectomy and parathyroidectomy].

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    doi:

    authors: Kovács EM,Rigó J Jr,Tóth M

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  • [Current pharmacotherapy of Parkinson's disease].

    abstract::Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The morbidity is about 1-2 of 1000 under 65 years, but it increases to 1-2 of 100 in the population over 65 years. PD became the model of degenerative disorders either concerning the etiopathogenesis or the therapeutic possibilities. Recen...

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    doi:

    authors: Takáts A

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  • [Laparoscopic appendectomy].

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    doi:

    authors: Antal A,Kiss T,Ezer P,Bátfai L

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  • [Pacemaker in MR: absolute contraindication?].

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    doi:10.1556/OH.2008.28122

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  • [Granulomatous hepatitis successfully treated with ursodeoxycholic acid].

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    doi:

    authors: Németh E,Bugovics E,Lengyel G,Pécsi G,Schaff Z,Fehér J

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  • [Introduction of a quality index in a Hungarian endoscopy unit].

    abstract:UNLABELLED:The quality of endoscopic examinations substantially determines their value. In developed countries, Continuous Quality Management is used to improve it permanently. In Hungary there is no example for measuring quality in the field of gastrointestinal endoscopy. AIM:The measurement and improvement of qualit...

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    doi:10.1556/OH.2012.29408

    authors: Gyökeres T,Rusznyák K,Visnyei Z,Schäfer E,Szamosi T,Banai J

    更新日期:2012-07-22 00:00:00

  • [Favourable effects of kidney transplantation on vascular condition of patients: Potential prognostic significance of non-invasive measurement of arterial stiffness].

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    doi:

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  • [Use of polymerase chain reaction DNA studies in Hungarian legal practice].

    abstract::The authors survey the application of polymerase chain reaction (PCR)-based DNA polymorphisms in the Hungarian forensic practice. The combined application of the presented 17 PCR-based sequence- or length-polymorphic DNA systems to criminal cases gives the power of individualization to the hand of the forensic scienti...

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    pub_type: 杂志文章,评审

    doi:

    authors: Woller J,Füredi S,Pádár Z

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  • [Experimental models in research of the pathomechanism of diabetes mellitus].

    abstract::The authors review the knowledge accumulated on animal models of diabetes during the last decade. The most commonly used diabetes models and the underlying disease processes are summarized, respectively. The best known diabetogenic substances, Streptozotocin and Alloxan are described, including their usage, dosage dos...

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  • [Successful operation of bleeding perforated Curling's ulcer].

    abstract::The Curling's ulcer is a special form of the stress ulcers which occurs in the stomach and duodenum in 2.0-25%. It's pathogenesis is unknown even though it is clearly related to larger burns poor early treatment and septic complications. Since the institution of routine prophylaxis of H2 receptor antagonists and antac...

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    doi:

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  • [Arrhytmogenic right ventricle--prognostic significance of exercise test].

    abstract:UNLABELLED:The authors summarize the present knowledge on arrhythmogenic right ventricular cardiomyopathy/dysplasia. Limited data are available about natural history of asymptomatic patients with arrhythmogenic right ventricle cardiomyopathy/dysplasia, who have a ventricular tachycardia during exercise test. A 25-year ...

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    pub_type: 杂志文章

    doi:10.1556/OH.2010.28995

    authors: Jánosi A,Vágó H,Hubay M

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  • [Antioxidant effect of vitamin E in experimental hyperlipidemia].

    abstract::The effect of Vitamin E treatment was studied in experimental hyperlipidaemia. The male Wistar rats got control diet and parallel fat rich diet contained 2% cholesterol, 0.5% cholic acid and 20% sunflower oil added into LATI food during 9 days. The treated hyperlipidemic animals got vitamin E for 9 days in daily 8.56 ...

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    pub_type: 杂志文章

    doi:

    authors: Horváth EM,Blázovics A,Kemény T,Vásárhelyi B,Weinbrenner Z,Fehér J

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  • Up-to-date management of acute traumatic bleeding and coagulopathy

    abstract::Major trauma is a frequent cause of death, and is the leading cause of death in the younger agegroups. Severe bleeding is often responsible for early mortality. The background of the latter is the trauma-induced coagulopathy (TIC), which - often very early - develops after the onset of bleeding. The high amount of blo...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/650.2020.31885

    authors: Szentkereszty Z

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  • [Post vaccination rotavirus surveillance in Hungary, in 2007].

    abstract::Vaccination is the main strategy to control severe dehydrating gastroenteritis caused by rotaviruses in early childhood. The availability of new generation rotavirus vaccines has led to an intensification of strain surveillance worldwide, in part, to gauge the impact of the possible vaccine-driven immune selection of ...

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  • [Budapest physicians practicing alternative medicine (based on a September 1991 survey)].

    abstract::Our essay is the first attempt to raise the problems related to the Hungarian alternative medicine and to outline the tendencies in this field. In our research we tried to find answers to the following questions: 1. whether the physicians in disadvantageous position show a greater tendency to start dealing with altern...

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    doi:

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  • [Activity of neutral endopeptidase in serum of patients with primary biliary cirrhosis].

    abstract::Neutral endopeptidase (neprilysin; EC 3.4.24.11) is present in the brush border membrane, for example in the bile ducts. We investigated serum neprilysin activity and its correlation with cholestatic markers in patients with primary biliary cirrhosis. Sera of 39 patients with primary biliary cirrhosis (37 females, 2 m...

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    pub_type: 杂志文章

    doi:

    authors: Horvát-Karajz K,Csepregi A,Nemesánszky E,Tulassay Z,Selmeci L,Szalay F

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  • [Role of ultrasonography in the urgent differential diagnosis of acute scrotum].

    abstract:UNLABELLED:Acute scrotum, when testicular torsion is suspected, needs emergency exploration. However, acute scrotum caused by torsion of the Morgagni hydatid and epididymitis can be managed conservatively. Real time colour Doppler ultrasound is becoming a more and more popular tool in the differential diagnosis, howeve...

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    pub_type: 杂志文章

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  • [Correlations between gastroesophageal reflux disease and obstructive sleep apnea].

    abstract:INTRODUCTION:Several studies have reported an increased prevalence of gastroesophageal reflux disease in patients with obstructive sleep apnea. The increasingly negative intrathoracic and transdiaphragmatic pressure should facilitate of reflux-events during apnea. AIMS:The aim of the present study was to investigate w...

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    pub_type: 杂志文章

    doi:

    authors: Demeter P,Várdi VK,Magyar P

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  • [Study of skeletal features in congenital hypodontia].

    abstract:INTRODUCTION:The incidence of congenital hypodontia is increasing in daily practice. Early diagnosis of this dental disorder and the associated skeletal malocclusions is crucial for successful and stable final rehabilitation. AIM:Comparison of cephalometric findings of patients with hypodontia of 1-4 teeth with the me...

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    pub_type: 杂志文章

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  • [Identifying rare genomic disorders with array comparative genomic hybridization in Hungary].

    abstract:INTRODUCTION:In the past decade the study of genomic disorders has received more interest. Array comparative genome hybridization is a widely spread diagnostic method in the research of genomic disorders. This method was implemented in the laboratory of the authors in 2012. AIM:This molecular cytogenetic method was fi...

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    pub_type: 杂志文章

    doi:10.1556/OH.2014.29825

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  • [Dissolving anxiety as an essential ingredient for any therapy].

    abstract::Anxiety frequently develops in human life and it is usually useful for the organism. Anxiety helps accomodation to the social environment, however, it may be harmful when it is intensive and long-lasting. It can also cause psychosomatic diseases. Anxiety may present itself as mild or moderate stress, psychosomatic dis...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2014.29925

    authors: Radics J

    更新日期:2014-06-01 00:00:00

  • [Certain aspects of continuous ventilation].

    abstract::The indication of mechanical ventilation is either a failing ventilatory function of the thorax or a failing gas exchange function of the lung. The ventilation affects every organ function in more or less degree. The starting point of long term ventilation is debated, arbitrary. Some ventilatory devices are simulating...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Incze F

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  • [Primary Spinal Tumor Registry at the National Centre for Spinal Disorders].

    abstract::Primary spinal tumors are rare diseases. Primary spinal tumor registry would be useful to help decision making in this complex field of spine surgery. In this article the authors present the latest findings from the Primary Spinal Tumor Registry at the National Centre for Spinal Disorders, Hungary. The registry is bas...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2014.29920

    authors: Szövérfi Z,Lazáry A,Varga PP

    更新日期:2014-05-11 00:00:00