[Interleukin-6 acts in different ways via soluble and membrane-bound receptors].

Abstract:

:Interleukin-6 is a multifunctional cytokine participating in the regulation of several immunologic and other cell-physiological phenomena. It acts via a receptor consisting of two components, that besides the ligand-specific chain also contains a second component of 130 kD (gp 130). The soluble form of the ligand-specific component of this receptor was shown to occur physiologically in body fluids and -following the binding of interleukin-6-to be capable of associating with the membrane-bound receptor component and inducing signal-transduction. We studied the possible differences between the effects of interleukin-6 exerted via membrane-bound or soluble receptors on HepG2 human hepatoma and primary rat hepatocyte cultures. We used two methods to study the action of interleukin-6: the mRNA expression of the protooncogene junB as an early marker, and the protein production of fibrinogen as a late one. The effect of interleukin-6 on both cell types examined with both methods used was lower via the soluble than the membrane-bound receptor. In addition, the soluble receptors alone (without interleukin-6) could induce the expression of the junB gene. Considering the wide-spread biological and pathological activities of interleukin-6 these phenomena could have some role in the pathogenesis of some diseases.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Igaz P,Tóth S,Madurka I,Falus A

subject

Has Abstract

pub_date

1998-07-19 00:00:00

pages

1741-4

issue

29

eissn

0030-6002

issn

1788-6120

journal_volume

139

pub_type

杂志文章
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    doi:

    authors: Kónya A,Vigváry Z

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  • [Pseudophaeochromocytoma (hypertensive crisis as a result of beta receptor hypersensitivity?)].

    abstract::The diagnosis of phaeocromocytoma could be excluded in a 57 year-old man suffering from "typical" hypertensive paroxysms by using modern standardized technics. The presented disorder which has been named pseudophaeochromocytoma may include different pathogenetical entities. In the observed case the background of the d...

    journal_title:Orvosi hetilap

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    doi:

    authors: Radó J,Arányi J,Deák G,Rétai G

    更新日期:1993-04-25 00:00:00

  • [Diagnostic possibilities in gastric leiomyoma in relation to two of our cases].

    abstract::Two cases of rare, benignant gastric tumors are reported. The suggest that while in the diagnosis of tumors with a mucous membrane involvement endoscopy has doubtless a leading role, tumors not infiltrating the mucous membrane are usually better recognizable by radiological (ultrasonography, computer tomography and do...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Pásztor E,Décsy J,Dévényi K,Sikula J,Altorjay I,Mikita J,Palatka K,Reményi G,Péter M

    更新日期:1999-11-07 00:00:00

  • [The use of Integra dermal regeneration matrix in the surgical treatment of a recurrent, extensive, malignant skin lesion in the temporal region].

    abstract::Authors report on the use of Integra dermal regeneration template after excision of an extended, recurrent skin tumor in the temporal region. The area covered with Integra was 180 cm2. Skin grafting to cover Integra was performed on the 28th day. Both Integra and the skin transplant were taken 100%. Integra dermal reg...

    journal_title:Orvosi hetilap

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    doi:10.1556/OH.2013.29535

    authors: Halmy C,Nádai Z,Csőre K,Vajda A,Tamás R

    更新日期:2013-02-10 00:00:00

  • [Immunohistologic changes of the intestinal mucosa in chronic inflammatory bowel diseases].

    abstract::In the pathogenesis of inflammatory bowel disease abnormally increased immune reactions in the intestinal mucosa play a basic role. The revealing of these reactions was facilitated by the rapidly spreading immunohistological methods in last decades. This review discusses in detail the characteristic distribution of ly...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Arató A

    更新日期:2002-12-08 00:00:00

  • [The effect of oxygenation on the biological behaviour of tumours].

    abstract::Malignant tumours often display hypoxic tissue areas where the oxygen tension is < 7 mm Hg. Studies in this field have proved that the hypoxic state boosts tumour progression and aggressive behaviour. In tissue culture experiments "in vitro" oxygenation was found to inhibit in itself the proliferation of cells of heal...

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    pub_type: 杂志文章,评审

    doi:10.1556/OH.2007.28024

    authors: Tóth J

    更新日期:2007-07-29 00:00:00

  • [Traveler's disease].

    abstract::The author expounds the reason of travellers' disease (bacterial-, viral-, parazitic infections). the most recently recognized pathogens (yersinia, campylobacterium, Clostridium perfringens, B. cereus, Cryptosporidium, rotavirus etc.), as well as the newest data on the pathomechanism of enteric infections have been sh...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Ferencz A

    更新日期:1998-07-12 00:00:00

  • [Dermatomyositis: clinical study of 34 patients].

    abstract::Clinical data of 34 patients with DM, who have been treated during the years 1971 and 1998 were evaluated. 79% of the patients (27 patients) were female, 21% of them (7 patients) were male. 59% of the patients (20 pts) were between the ages of 41 and 50 years. The characteristic heliotrop rash were observed in 26 pati...

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    pub_type: 杂志文章

    doi:

    authors: Marschalkó M,Pónyai G,Ablonczy E,Horváth A

    更新日期:2000-01-30 00:00:00

  • [Physical measurement of the dorsal kyphosis in 14-17-year old patients with Scheuermann's disease and in matched healthy controls].

    abstract::The modified use of the Debrunner-kyphometer (a special protractor to measure the dorsal kyphosis by an objective physical method) is presented. After proving the validity and reproducibility of the measuring method, the dorsal kyphosis of patients with Scheuermann's disease and of matched healthy controls was measure...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Somhegyi A,Tóth Z,Ratkó I

    更新日期:1992-03-22 00:00:00

  • [Perspectives in the management of congenital heart defects in adult patients].

    abstract::Due to improving results in congenital heart surgery, the number of adult patients with congenital heart defect is increasing. The question is: what kind of problems can be managed in this patient-group? The authors review the different problems of management of congenital heart defects in adults based on national and...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2015.30072

    authors: Hartyánszky I,Varga S,Havasi K,Babik B,Katona M,Bogáts G

    更新日期:2015-01-18 00:00:00

  • [Successful operation of bleeding perforated Curling's ulcer].

    abstract::The Curling's ulcer is a special form of the stress ulcers which occurs in the stomach and duodenum in 2.0-25%. It's pathogenesis is unknown even though it is clearly related to larger burns poor early treatment and septic complications. Since the institution of routine prophylaxis of H2 receptor antagonists and antac...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Baksa J

    更新日期:1991-02-24 00:00:00

  • [Movement-activated [15O]-butanol PET scan in patients with Parkinson disease].

    abstract::The regional cerebral perfusion has been studied by [15O]-butanol PET in bradykinetic patients with Parkinson's disease. In comparison with the rest condition significantly higher perfusion was detected in the primary sensorimotor cortex, parietal cortex, premotor cortex and supplementary motor area. A decrease of act...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Valálik I,Emri M,Lengyel Z,Julow J,Trón L

    更新日期:2002-05-26 00:00:00

  • [Attitude of patients and customers toward on-line purchase of drugs--a Hungarian survey by community pharmacies].

    abstract::As internet is now available to nearly everyone in Hungary, the accessibility of websites offering pharmaceutical products is also increasing. The national and international regulation of these sites is currently an unsolved problem worldwide, thus potentially harmful, counterfeit and prescription only medicines are e...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2010.28974

    authors: Fittler A,Bosze G,Botz L

    更新日期:2010-11-28 00:00:00

  • [Three-dimensional speckle-tracking echocardiography -- a further step in non-invasive three-dimensional cardiac imaging].

    abstract::Three-dimensional speckle-tracking echocardiography is a new cardiac imaging methodology, which allows three-dimensional non-invasive evaluation of the myocardial mechanics. The aim of this review is to present this new tool emphasizing its diagnostic potentials and demonstrating its limitations, as well. ...

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    pub_type: 杂志文章,评审

    doi:10.1556/OH.2012.29466

    authors: Nemes A,Kalapos A,Domsik P,Forster T

    更新日期:2012-10-07 00:00:00

  • [Identifying rare genomic disorders with array comparative genomic hybridization in Hungary].

    abstract:INTRODUCTION:In the past decade the study of genomic disorders has received more interest. Array comparative genome hybridization is a widely spread diagnostic method in the research of genomic disorders. This method was implemented in the laboratory of the authors in 2012. AIM:This molecular cytogenetic method was fi...

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    doi:10.1556/OH.2014.29825

    authors: Duga B,Czakó M,Hadzsiev K,Komlósi K,Sümegi K,Kisfali P,Kosztolányi G,Melegh B

    更新日期:2014-03-02 00:00:00

  • [Williams-Beuren syndrome (Williams syndrome). Case report].

    abstract::Williams syndrome is a rare genetic disorder, that occurs equally in all ethnic groups and both sexes. The diagnosis might be missed during childhood in mild cases. However, establishing the diagnosis is important, not only to find the cause of intellectual disability but to look for cardiovascular, endocrine, psychia...

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    pub_type: 杂志文章

    doi:10.1556/650.2017.30905

    authors: Miklós G,Fekete G,Haltrich I,Tóth M,Reismann P

    更新日期:2017-11-01 00:00:00

  • [Therapy of mental states at high risk for psychosis: preliminary results from Hungary].

    abstract:INTRODUCTION:Recent evidence raised the possibility that low-dose antipsychotic treatment during the prodromal phase may prevent the development of full-blown psychosis. AIMS:To investigate the effectiveness of low-dose antipsychotic medication in the prevention of psychosis. METHODS:Fifty-two persons who fulfilled t...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kéri S,Kelemen O,Janka Z

    更新日期:2006-02-05 00:00:00

  • [Onset of Philadelphia chromosome negative chronic myeloid leukemia with symptoms of intrahepatic cholestasis].

    abstract::The case of a chronic myelogenous leukemia (CML) starting in an unusual form in a young woman is reported. Rapidly progressing icterus was the first and leading symptom of the disease. Simultaneously with the exclusion of the possibility of hepatitis and extrahepatic obstruction of the bile duct the qualitative blood ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Döbrönte Z,Bodnár M,Löcsei Z,Brittig F,Varga L,István L

    更新日期:1989-10-22 00:00:00

  • [Subacute ischemic damage in jejunal loops used for esophageal reconstruction].

    abstract::The authors observed ischaemic damages in jejunal loops used for esophageal reconstruction with full or partial regeneration. In addition to the case reports, they discuss the cause, the mechanism, the possible prevention and correction of this rare complication. ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Vereczkei A,Rozsos I,Dérczy K,Horváth OP

    更新日期:1997-11-23 00:00:00

  • [Acute viral hepatitis: pathogenesis and clinical manifestations].

    abstract::This is a review of several mechanisms in the acute and chronic progress of viral hepatitis. Investigation of these mechanisms may have an important role in the diagnosis and treatment of chronic hepatitis. Clinical features of acute non-A, non-B hepatitis were studied in 110 patients. Most of the patients had a surgi...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Dalmi L,Weisz G,Kovács J

    更新日期:1992-07-05 00:00:00

  • [Extracellular vesicles and their role in hematological malignancies].

    abstract::Extracellular vesicles are produced in all organisms. The most intensively investigated categories of extracellular vesicles include apoptotic bodies, microvesicles and exosomes. Among a very wide range of areas, their role has been confirmed in intercellular communication, immune response and angiogenesis (in both ph...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2016.30532

    authors: Rzepiel A,Kutszegi N,Cs Sági J,Kelemen A,Pálóczi K,F Semsei Á,Buzás E,Erdélyi DJ

    更新日期:2016-08-01 00:00:00

  • [Vitamin D and calcium in the mirror of clinical evidence].

    abstract::The biological mechanisms, ecological and observational studies indicate increased morbidity and mortality in vitamin D deficiency, while the controlled, randomized supplementation trials - carried out mostly in vitamin D deficient patients - have shown no or some marginal benefits, mostly in preventing institutionali...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/650.2016.30419

    authors: Bajnok L

    更新日期:2016-07-01 00:00:00

  • [Lycopene--a natural antioxidant].

    abstract::Lycopene is a carotenoid found predominantly in tomatoes and tomato products. In contrast to beta-carotene it is not a precursor of vitamin A in humans. Lycopene is not destroyed during food processing, moreover its bioavailability improves. Lycopene is the most powerful antioxidant amongst carotenoids. Beside the ant...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Bánhegyi G

    更新日期:2005-07-31 00:00:00

  • [New lasers in dermatologic surgery].

    abstract::Developments in the fields of laser technology and application have significantly broadened its clinical use over the past two decades. As lasers became more smaller, more reliable and less expensive, dermatology will benefit new laser-based therapeutic and diagnostic methods. Relevant laser systems and their clinical...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Morvay M

    更新日期:1995-04-30 00:00:00

  • ["Folie a deux hallucinatoire"--a new case of induced hallucinatory psychosis. A new entity?].

    abstract::The authors in their case report show a case of induced hallucinatory psychosis induced in a wife of a patient with alcoholic hallucinosis. They deal with the nosological position of "folie a deux hallucinatoire" (induced hallucinatory psychosis) and integrate the consequences of the case to the general psychopatholog...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Tényi T,Tamás L,Pásztor A,Herold R,Trixler M

    更新日期:1999-06-20 00:00:00

  • [Transient left ventricular dysfunction: special form of stress cardiomyopathy].

    abstract:INTRODUCTION:The phenomenon of stress induced left ventricular dysfunction has been long recognised. A special reversible form of it, characterized by left ventricular apical dilatation, is the so-called "tako-tsubo" or ampoule cardiomyopathy, based on its first description by Sato et al. in 1990. The tako-tsubo cardio...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:10.1556/OH.2008.28181

    authors: Tomcsányi J,Somlói M,Frész T,Arabadzisz H,Toldy-Schedel E,Sármán B,Zsoldos A,Nagy E,Farbaky Z

    更新日期:2008-02-24 00:00:00

  • [Urinary calcium excretion. (Normal values for urinary calcium/creatinine ratio in Hungary). Multicenter study].

    abstract::Metabolic bone disorders have attracted increasing attention in Hungary due to their significant impact on public health care. Measuring urinary calcium excretion is the first step in the biochemical assessment of bone metabolism. Fasting urinary calcium corrected by creatinine excretion is widely used all over the wo...

    journal_title:Orvosi hetilap

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Lakatos P,Takács I,Büki B,Németh J,Horváth C

    更新日期:1997-06-01 00:00:00

  • [Radiosurgery of the brain at the beginning of the 21st century: gamma knife with C-table].

    abstract::The goal of stereotactic radiosurgery by definition is "the delivery of a single, high dose of radiation allowing the precise and complete destruction of chosen target structures containing healthy and/or pathological cells, without significant concomitant or late radiation damage to adjacent tissues". This effect is ...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

    authors: Szeifert G,Levivier M,Kondziolka D,Lunsford D,Brotchi J,Nyáry I

    更新日期:2001-10-07 00:00:00

  • [Benign tumor of the small intestine causing recurrent hemorrhage].

    abstract::The authors reported a 56-year-old man, who suffered from repeated massive gastrointestinal bleeding. The source of the bleeding was leiomyoma of the ileum. Abdominal computertomography and selective enterography confirmed the tumour's localisation. After partial resection of the ileum the patient had no more complain...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Györi I,Márton E,Kiss J,Petrovics A,Rapi J,Nagy B,Vértes E

    更新日期:1999-03-14 00:00:00

  • [Noninvasive imaging of the proximal coronary arteries by transesophageal echocardiography].

    abstract::Authors give an account of their experiences about the visualization of the proximal coronary arteries on the basis of the transesophageal echocardiographic examination of 45 patients. According to their observations the left main coronary artery, the bifurcation, the left anterior descending artery and the circumflex...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章

    doi:

    authors: Horváth M,Radó J,Gonda F,Varga M

    更新日期:1992-10-04 00:00:00