Abstract:
:The signaling network involved in the pathogenesis of periodontal disease is not yet fully understood. This review aims to describe possible mechanisms through which the bacterial modulators may be linked directly or indirectly to the process of alveolar bone loss in periodontitis. From the late 1970s to present, new paradigm shifts have been developed regarding our understanding of pathological bone remodeling in periodontal disease. Upcoming evidence suggests that in periodontal disease the local immune response is exacerbated and involves the existence of signaling pathways that have been shown to modulate bone-cell function leading to alveolar bone loss. Those complex signaling pathways have been observed not only between bacteria but also between bacteria and the gingival surface of the host. More specifically, it has been shown that bacteria, through their secretion molecules, may interact indirectly and directly with immune-type cells of the host, resulting in the production of osteolytic agents that enhance bone resorption. Further research is required to provide a clear understanding of the role of these molecules in the pathogenesis of periodontal disease, and the availability of new technologies, such as next-generation sequencing and metagenomic analysis, may be useful tools in achieving this.
journal_name
Periodontol 2000journal_title
Periodontology 2000authors
Henderson B,Kaiser Fdoi
10.1111/prd.12160subject
Has Abstractpub_date
2018-02-01 00:00:00pages
97-108issue
1eissn
0906-6713issn
1600-0757journal_volume
76pub_type
杂志文章,评审abstract::Treatment of periodontitis aims at preventing further disease progression with the intentions to reduce the risk of tooth loss, minimize symptoms and perception of the disease, possibly restore lost periodontal tissue and provide information on maintaining a healthy periodontium. Therapeutic intervention includes intr...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12201
更新日期:2017-10-01 00:00:00
abstract::Studies ranging from preclinical animal models to human clinical trials support the basic hypothesis that the inhibition of local arachidonic acid metabolites with nonsteroidal anti-inflammatory drugs slows periodontal disease progression. Data on modulation of other host mediators such as cytokines and NO remain rest...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0757.2000.2240112.x
更新日期:2000-10-01 00:00:00
abstract::Two dominant factors dictate which ingredients are used in formulating toothpaste and mouthwashes. The major one is the type of active ingredient chosen, especially cationic active ingredients such as chlorhexidine; the other factor is the needs of the consumer. Apart from gum health benefits, the consumer expects to ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1997.tb00102.x
更新日期:1997-10-01 00:00:00
abstract::Diagnostic radiology is an essential component of treatment planning in the field of implant dentistry. This narrative review will present current concepts for the use of cone beam computed tomography imaging, before and after implant placement, in daily clinical practice and research. Guidelines for the selection of ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12161
更新日期:2017-02-01 00:00:00
abstract::This paper is aimed to present a biomaterials perspective in implant therapy that fosters improved bone response and long-term biomechanical competence from surgical instrumentation to final prosthetic rehabilitation. Strategies to develop implant surface texturing will be presented and their role as an ad hoc treatme...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12288
更新日期:2019-10-01 00:00:00
abstract::Maxillary sinus augmentation is the most predictable of the pre-prosthetic surgical procedures. There are, however, known and well-documented complications that can and do occur. The most common are the intraoperative complications of sinus membrane perforation and bleeding, and the postoperative complications of sinu...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12286
更新日期:2019-10-01 00:00:00
abstract::Despite the fact that several clinical studies have shown additional benefits when certain systemic antibiotics are used as adjuncts to periodontal treatment, clear guidelines for the use of these agents in the clinical practice are not yet available. Basic questions concerning the use of systemic antibiotics to treat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12075
更新日期:2015-02-01 00:00:00
abstract::There has been immense interest in the uses of saliva in the diagnosis of systemic disease over the past decade and longer because it is recognized that saliva possesses great potential as a diagnostic fluid. In spite of this, the usefulness of saliva in studies of the epidemiology of human disease has still to be pro...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12108
更新日期:2016-02-01 00:00:00
abstract::For computer-guided surgery a static surgical guide is used that transfers the virtual implant position from computerized tomographic data to the surgical site. These guides are produced by computer-aided design/computer-assisted manufacture technology, such as stereolithography, or manually in a dental laboratory (us...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12056
更新日期:2014-10-01 00:00:00
abstract::Translation of experimental data to the clinical setting requires the safety and efficacy of such data to be confirmed in animal systems before application in humans. In dental research, the animal species used is dependent largely on the research question or on the disease model. Periodontal disease and, by analogy, ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12052
更新日期:2015-06-01 00:00:00
abstract::Periodontitis is a complex infectious disease that affects low-income individuals disproportionately. Periodontitis is associated with specific bacterial species and herpesviruses, and successful prevention and treatment of the disease is contingent upon effective control of these pathogens. This article presents an e...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/j.1600-0757.2011.00429.x
更新日期:2012-10-01 00:00:00
abstract::The primary goal of periodontal therapy is to produce an environment that is conducive to oral health. This is achieved by eliminating the subgingival infection and implementing supragingival plaque control measures designed to prevent the re-colonization of the sulcus. Local etiologic factors, as described above, my ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1046/j.0906-6713.2003.003429.x
更新日期:2004-01-01 00:00:00
abstract::Surgical procedures of the oral cavity can be performed by a number of dental specialists and clinicians. Because of the limited number of surgical procedures that can be performed inside the oral cavity, the boundaries between specialties may become indistinct and lead to confusion for general dentists in terms of pa...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12196
更新日期:2017-06-01 00:00:00
abstract::Oral mucosal diseases encompass a diverse array of conditions and disorders arising from malignant, potentially malignant, and nonneoplastic processes. Considerable attention has been paid to the former in recent years, much less to the wide range of nonneoplastic disease processes, which constitute a sizeable proport...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12272
更新日期:2019-06-01 00:00:00
abstract::The periodontium is a very dynamic organ that responds rapidly to mechanical and chemical stimuli. It is very complex in that it is composed of two hard tissues (cementum and bone) and two soft connective tissues (periodontal ligament and gingiva). Together these tissues are defined by the molecules expressed by the r...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/prd.12037
更新日期:2013-10-01 00:00:00
abstract::The focus of this review on periodontal self-care will be based primarily on the results of systematic reviews and meta-analyses. Based on the evidence gleaned from systematic reviews, it is notable that most authors of these reviews commented on the relatively small number of trials that could pass the quality-assess...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12012
更新日期:2013-06-01 00:00:00
abstract::This paper focuses on plaque control and the management of gingivitis in adults and summarizes the evidence of commercially available dentifrices as gathered from existing systematic reviews. Three internet sources were used to search for appropriate papers (up to and including February 2017). The search strategy was ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12257
更新日期:2019-02-01 00:00:00
abstract::The zygoma implant has been an effective option in the management of the atrophic edentulous maxilla as well as for maxillectomy defects. Brånemark introduced the zygoma implant not only as a solution to obtain posterior maxillary anchorage but also to expedite the rehabilitation process. The zygoma implant is a thera...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12038
更新日期:2014-10-01 00:00:00
abstract::Periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. Herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. In 26 recent studies from 15 countries, subgingival cyt...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12085
更新日期:2015-10-01 00:00:00
abstract::The most important development in the epidemiology of periodontitis in the USA during the last decade is the result of improvements in survey methodologies and statistical modeling of periodontitis in adults. Most of these advancements have occurred as the direct outcome of work by the joint initiative known as the Pe...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12323
更新日期:2020-02-01 00:00:00
abstract::We have compiled, in this Periodontology 2000 review, all Latin American literature on experimental and clinical studies of periodontal plastic procedures. The body of literature on this subject has led to a discussion of the features and treatment outcomes of root-coverage procedures. Over time, knowledge on periodon...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12247
更新日期:2019-02-01 00:00:00
abstract::This article provides an up-to-date review of the more robust salivary biomarkers, as well as of panels of combinatorial markers and periodontal pathogens, that reveal high sensitivity and specificity for enhancing clinical decision-making in periodontal disease progression, risk and diagnosis. Periodontal diseases ar...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12103
更新日期:2016-02-01 00:00:00
abstract::This chapter affirms that drugs and medicaments may have a profound effect on the periodontal structures. In some instances, such as drug-induced melanosis, the effect may be insignificant to the health of the patient. In other circumstances, drug-induced disorders may initiate painful, destructive disease processes t...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1998.tb00136.x
更新日期:1998-10-01 00:00:00
abstract::Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging on the composition of subgingival biofilms remains unclear. In the present article, we provide an overview...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12136
更新日期:2016-10-01 00:00:00
abstract::An extensive body of experimental and clinical evidence documents the negative impact of chronic psychological stress and depression on the immune system and health. Chronic stress and depression can result in general dysregulation of the immune system, of both cellular and humoral pathways, which may contribute to pa...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12036
更新日期:2014-02-01 00:00:00
abstract::A number of systemic disorders increase a patient's susceptibility to destructive periodontitis and have impacts on periodontal disease progression and severity. The underlying factors are usually genetic and are mainly related to alterations in the immune response and in certain endocrine functions, leading to variou...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12015
更新日期:2014-06-01 00:00:00
abstract::Cardiovascular diseases still account for the majority of deaths worldwide, although significant improvements in survival, after being affected by cardiovascular disease, have been achieved in the last decades. Periodontal diseases are also a common global burden. Several studies have shown a link between cardiovascul...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12302
更新日期:2020-06-01 00:00:00
abstract::The discovery of neutrophil extracellular traps in 2004 opened a fascinating new chapter in immune-mediated microbial killing. Brinkman et al. demonstrated that neutrophils, when catastrophically stimulated, undergo a novel form of programmed cell death (neutrophil extracellular trap formation) whereby they decondense...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12025
更新日期:2013-10-01 00:00:00
abstract::Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Since the 1990s, multiple epidemiologic, experimental...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12344
更新日期:2020-06-01 00:00:00
abstract::MicroRNAs (miRNAs) are a family of small, noncoding RNA molecules that negatively regulate protein expression either by inhibiting initiation of the translation of mRNA or by inducing the degradation of mRNA molecules. Accumulating evidence suggests that miRNA-mediated repression of protein expression is of paramount ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12095
更新日期:2015-10-01 00:00:00