Personalized medicine: an update of salivary biomarkers for periodontal diseases.

Abstract:

:This article provides an up-to-date review of the more robust salivary biomarkers, as well as of panels of combinatorial markers and periodontal pathogens, that reveal high sensitivity and specificity for enhancing clinical decision-making in periodontal disease progression, risk and diagnosis. Periodontal diseases are complex and require an inflammatory response to bacterial pathogens in a susceptible host to stimulate tissue destruction. When used alone, traditional clinical assessments provide a diagnosis of periodontitis only after the biologic onset of the disease process, and are unable to substantiate disease activity or future risk. New technologies are becoming available that are capable of measuring combinations of inflammatory cytokines and proteinases for rapid chair-side testing. Utilizing saliva to identify and measure specific phenotypes and host-derived mediators will allow highly individualized diagnosis, prognosis and treatments for periodontal diseases. This personalized medicine approach will strengthen the power of the clinical oral examination and medical history assessments, providing patients with evidence-based, targeted risk care.

journal_name

Periodontol 2000

journal_title

Periodontology 2000

authors

Korte DL,Kinney J

doi

10.1111/prd.12103

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

26-37

issue

1

eissn

0906-6713

issn

1600-0757

journal_volume

70

pub_type

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