Abstract:
:Periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. Herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. In 26 recent studies from 15 countries, subgingival cytomegalovirus, Epstein-Barr virus and herpes simplex virus type 1, respectively, yielded median prevalences of 49%, 45% and 63% in aggressive periodontitis, 40%, 32% and 45% in chronic periodontitis, and 3%, 7% and 12% in healthy periodontium. An active herpesvirus infection of the periodontium exhibits site specificity, is a potent stimulant of cellular immunity, may cause upgrowth of periodontopathic bacteria and tends to be related to disease-active periodontitis. Pro-inflammatory cytokines induced by the herpesvirus infection may activate matrix metalloproteinases and osteoclasts, leading to breakdown of the tooth-supportive tissues. The notion that a co-infection of herpesviruses and specific bacteria causes periodontitis provides a plausible etiopathogenic explanation for the disease. Moreover, herpesvirus virions from periodontal sites may dislodge into saliva or enter the systemic circulation and cause diseases beyond the periodontium. Periodontal treatment can diminish significantly the periodontal load of herpesviruses, which may lower the incidence and magnitude of herpesvirus dissemination within and between individuals, and subsequently the risk of acquiring a variety of medical diseases. Novel and more effective approaches to the prevention and treatment of periodontitis and related diseases may depend on a better understanding of the herpesvirus-bacteria-immune response axis.
journal_name
Periodontol 2000journal_title
Periodontology 2000authors
Slots Jdoi
10.1111/prd.12085subject
Has Abstractpub_date
2015-10-01 00:00:00pages
28-45issue
1eissn
0906-6713issn
1600-0757journal_volume
69pub_type
杂志文章,评审abstract::This article provides an up-to-date review of the more robust salivary biomarkers, as well as of panels of combinatorial markers and periodontal pathogens, that reveal high sensitivity and specificity for enhancing clinical decision-making in periodontal disease progression, risk and diagnosis. Periodontal diseases ar...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12103
更新日期:2016-02-01 00:00:00
abstract::Treatment of periodontitis aims at preventing further disease progression with the intentions to reduce the risk of tooth loss, minimize symptoms and perception of the disease, possibly restore lost periodontal tissue and provide information on maintaining a healthy periodontium. Therapeutic intervention includes intr...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12201
更新日期:2017-10-01 00:00:00
abstract::The periodontium is a very dynamic organ that responds rapidly to mechanical and chemical stimuli. It is very complex in that it is composed of two hard tissues (cementum and bone) and two soft connective tissues (periodontal ligament and gingiva). Together these tissues are defined by the molecules expressed by the r...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/prd.12037
更新日期:2013-10-01 00:00:00
abstract::In the 1960s and 1970s, implant-supported prostheses based on subperiosteal or blade implants had a poor reputation because of questionable clinical outcomes and lack of scientific documentation. The change to a scientifically sound discipline was initiated by the two scientific pioneers of modern implant dentistry, P...
journal_title:Periodontology 2000
pub_type: 历史文章,杂志文章,评审
doi:10.1111/prd.12185
更新日期:2017-02-01 00:00:00
abstract::There is increasing public interest in natural or herbal-based healthcare products. This trend is not only visible in supermarkets and dental practices, but also in the scientific world. An improving number of clinical trials are being conducted to validate the claims made about these products in regards to periodonta...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12339
更新日期:2020-10-01 00:00:00
abstract::For computer-guided surgery a static surgical guide is used that transfers the virtual implant position from computerized tomographic data to the surgical site. These guides are produced by computer-aided design/computer-assisted manufacture technology, such as stereolithography, or manually in a dental laboratory (us...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12056
更新日期:2014-10-01 00:00:00
abstract::Periodontal diseases are chronic inflammatory, multifactorial diseases where the major triggering factors for disease onset are bacteria and their toxins, but the major part of tissue destruction occurs as a result of host response towards the periodontal microbiome. Periodontal microbiome consists of a wide range of ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12355
更新日期:2021-02-01 00:00:00
abstract::The discovery of neutrophil extracellular traps in 2004 opened a fascinating new chapter in immune-mediated microbial killing. Brinkman et al. demonstrated that neutrophils, when catastrophically stimulated, undergo a novel form of programmed cell death (neutrophil extracellular trap formation) whereby they decondense...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12025
更新日期:2013-10-01 00:00:00
abstract::Recall sessions are an integral part of supportive periodontal therapy. The aim of the current article is to review the existing evidence to support if and to what extent a predefined frequency of periodontal recall sessions ensures periodontal health and stability. Factors that potentially affect the time interval fo...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12340
更新日期:2020-10-01 00:00:00
abstract::This paper focuses on plaque control and the management of gingivitis in adults and summarizes the evidence of commercially available dentifrices as gathered from existing systematic reviews. Three internet sources were used to search for appropriate papers (up to and including February 2017). The search strategy was ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12257
更新日期:2019-02-01 00:00:00
abstract::The definition of osteoporosis has evolved beyond low bone mineral density to include impaired bone morphology and matrix properties. As such, the subsequent bone density insufficiencies extend beyond the skeletal risks of fracture and have implications for oral health management patients. As our population ages there...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.2011.00400.x
更新日期:2013-02-01 00:00:00
abstract::Numerous biological and cultural factors influence the microbial communities (microbiota) that inhabit the human mouth, including diet, environment, hygiene, physiology, health status, genetics, and lifestyle. As oral microbiota can underpin oral and systemic diseases, tracing the evolutionary history of oral microbio...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/prd.12353
更新日期:2021-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are a family of small, noncoding RNA molecules that negatively regulate protein expression either by inhibiting initiation of the translation of mRNA or by inducing the degradation of mRNA molecules. Accumulating evidence suggests that miRNA-mediated repression of protein expression is of paramount ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12095
更新日期:2015-10-01 00:00:00
abstract::There has been immense interest in the uses of saliva in the diagnosis of systemic disease over the past decade and longer because it is recognized that saliva possesses great potential as a diagnostic fluid. In spite of this, the usefulness of saliva in studies of the epidemiology of human disease has still to be pro...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12108
更新日期:2016-02-01 00:00:00
abstract::This paper is aimed to present a biomaterials perspective in implant therapy that fosters improved bone response and long-term biomechanical competence from surgical instrumentation to final prosthetic rehabilitation. Strategies to develop implant surface texturing will be presented and their role as an ad hoc treatme...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12288
更新日期:2019-10-01 00:00:00
abstract::Translation of experimental data to the clinical setting requires the safety and efficacy of such data to be confirmed in animal systems before application in humans. In dental research, the animal species used is dependent largely on the research question or on the disease model. Periodontal disease and, by analogy, ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12052
更新日期:2015-06-01 00:00:00
abstract::Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Since the 1990s, multiple epidemiologic, experimental...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12344
更新日期:2020-06-01 00:00:00
abstract::Studies ranging from preclinical animal models to human clinical trials support the basic hypothesis that the inhibition of local arachidonic acid metabolites with nonsteroidal anti-inflammatory drugs slows periodontal disease progression. Data on modulation of other host mediators such as cytokines and NO remain rest...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0757.2000.2240112.x
更新日期:2000-10-01 00:00:00
abstract::This review provides an update on genome-wide association studies in periodontitis. Studies in populations with European ancestry have dominated the landscape of periodontitis genetics studies but, increasingly, studies in Asian populations are being reported. The review also summarizes evidence for suggested associat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12232
更新日期:2018-10-01 00:00:00
abstract::Although the prevalence of tobacco use has declined in some parts of the world, tobacco use remains a persistent and, in some cases, growing problem that will continue to be a fundamental challenge facing dental practitioners in the decades ahead. Dental practitioners have a unique opportunity and professional obligat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12120
更新日期:2016-06-01 00:00:00
abstract::This chapter affirms that drugs and medicaments may have a profound effect on the periodontal structures. In some instances, such as drug-induced melanosis, the effect may be insignificant to the health of the patient. In other circumstances, drug-induced disorders may initiate painful, destructive disease processes t...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1998.tb00136.x
更新日期:1998-10-01 00:00:00
abstract::Maxillary sinus augmentation is the most predictable of the pre-prosthetic surgical procedures. There are, however, known and well-documented complications that can and do occur. The most common are the intraoperative complications of sinus membrane perforation and bleeding, and the postoperative complications of sinu...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12286
更新日期:2019-10-01 00:00:00
abstract::Diagnostic radiology is an essential component of treatment planning in the field of implant dentistry. This narrative review will present current concepts for the use of cone beam computed tomography imaging, before and after implant placement, in daily clinical practice and research. Guidelines for the selection of ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12161
更新日期:2017-02-01 00:00:00
abstract::The zygoma implant has been an effective option in the management of the atrophic edentulous maxilla as well as for maxillectomy defects. Brånemark introduced the zygoma implant not only as a solution to obtain posterior maxillary anchorage but also to expedite the rehabilitation process. The zygoma implant is a thera...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12038
更新日期:2014-10-01 00:00:00
abstract::Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging on the composition of subgingival biofilms remains unclear. In the present article, we provide an overview...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12136
更新日期:2016-10-01 00:00:00
abstract::A number of systemic disorders increase a patient's susceptibility to destructive periodontitis and have impacts on periodontal disease progression and severity. The underlying factors are usually genetic and are mainly related to alterations in the immune response and in certain endocrine functions, leading to variou...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12015
更新日期:2014-06-01 00:00:00
abstract::The primary goal of periodontal therapy is to produce an environment that is conducive to oral health. This is achieved by eliminating the subgingival infection and implementing supragingival plaque control measures designed to prevent the re-colonization of the sulcus. Local etiologic factors, as described above, my ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1046/j.0906-6713.2003.003429.x
更新日期:2004-01-01 00:00:00
abstract::The signaling network involved in the pathogenesis of periodontal disease is not yet fully understood. This review aims to describe possible mechanisms through which the bacterial modulators may be linked directly or indirectly to the process of alveolar bone loss in periodontitis. From the late 1970s to present, new ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12160
更新日期:2018-02-01 00:00:00
abstract::Dentists need to make daily decisions regarding patient care, and these decisions should essentially be scientifically sound. Evidence-based dentistry is meant to empower clinicians to provide the most contemporary treatment. The benefits of applying the evidence-based method in clinical practice include application o...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.2011.00437.x
更新日期:2012-06-01 00:00:00
abstract::The most important development in the epidemiology of periodontitis in the USA during the last decade is the result of improvements in survey methodologies and statistical modeling of periodontitis in adults. Most of these advancements have occurred as the direct outcome of work by the joint initiative known as the Pe...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12323
更新日期:2020-02-01 00:00:00