Abstract:
:A number of systemic disorders increase a patient's susceptibility to destructive periodontitis and have impacts on periodontal disease progression and severity. The underlying factors are usually genetic and are mainly related to alterations in the immune response and in certain endocrine functions, leading to various syndromes in which periodontitis and/or early tooth loss are secondary manifestations. Neutrophils are important immune defense cells that play a significant role in controlling the spread of microbial plaque infections in the dentogingival region. This review focuses on a selected group of systemic disorders that are associated with alterations in either neutrophil counts (quantitative disorders) or function (qualitative disorders), and defects in the mineralization of bone and dental tissues. In most of these diseases controlling the periodontal disease progression is very challenging. Proper diagnosis is a prerequisite for proper management of the periodontal problem. Future advances in research, including gene targeting and the resolution of enzyme deficiencies, may bring about remedies of the underlying systemic disorders and may significantly improve the outcome of periodontal treatment in these patients.
journal_name
Periodontol 2000journal_title
Periodontology 2000authors
Khocht A,Albandar JMdoi
10.1111/prd.12015subject
Has Abstractpub_date
2014-06-01 00:00:00pages
134-48issue
1eissn
0906-6713issn
1600-0757journal_volume
65pub_type
杂志文章,评审abstract::Cardiovascular diseases still account for the majority of deaths worldwide, although significant improvements in survival, after being affected by cardiovascular disease, have been achieved in the last decades. Periodontal diseases are also a common global burden. Several studies have shown a link between cardiovascul...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12302
更新日期:2020-06-01 00:00:00
abstract::There is increasing public interest in natural or herbal-based healthcare products. This trend is not only visible in supermarkets and dental practices, but also in the scientific world. An improving number of clinical trials are being conducted to validate the claims made about these products in regards to periodonta...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12339
更新日期:2020-10-01 00:00:00
abstract::There has been immense interest in the uses of saliva in the diagnosis of systemic disease over the past decade and longer because it is recognized that saliva possesses great potential as a diagnostic fluid. In spite of this, the usefulness of saliva in studies of the epidemiology of human disease has still to be pro...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12108
更新日期:2016-02-01 00:00:00
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journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12075
更新日期:2015-02-01 00:00:00
abstract::This review provides an update on genome-wide association studies in periodontitis. Studies in populations with European ancestry have dominated the landscape of periodontitis genetics studies but, increasingly, studies in Asian populations are being reported. The review also summarizes evidence for suggested associat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12232
更新日期:2018-10-01 00:00:00
abstract::The concept of precision dentistry as it relates to precision medicine is relatively new to the field of oral health. Precision dentistry is a contemporary, multifaceted, data-driven approach to oral health care that uses individual characteristics to stratify similar patients into phenotypic groups. The objective is ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12314
更新日期:2020-02-01 00:00:00
abstract::Recall sessions are an integral part of supportive periodontal therapy. The aim of the current article is to review the existing evidence to support if and to what extent a predefined frequency of periodontal recall sessions ensures periodontal health and stability. Factors that potentially affect the time interval fo...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12340
更新日期:2020-10-01 00:00:00
abstract::Studies ranging from preclinical animal models to human clinical trials support the basic hypothesis that the inhibition of local arachidonic acid metabolites with nonsteroidal anti-inflammatory drugs slows periodontal disease progression. Data on modulation of other host mediators such as cytokines and NO remain rest...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0757.2000.2240112.x
更新日期:2000-10-01 00:00:00
abstract::Translation of experimental data to the clinical setting requires the safety and efficacy of such data to be confirmed in animal systems before application in humans. In dental research, the animal species used is dependent largely on the research question or on the disease model. Periodontal disease and, by analogy, ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12052
更新日期:2015-06-01 00:00:00
abstract::Periodontal microbiology has historically been based on an "us against them" paradigm, one that focuses mainly on identifying microbes and viruses that cause disease. However, such a bottom-up approach limits our appreciation of the incredible diversity of this ecosystem and the essential ways in which microbial inter...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12373
更新日期:2021-02-01 00:00:00
abstract::For computer-guided surgery a static surgical guide is used that transfers the virtual implant position from computerized tomographic data to the surgical site. These guides are produced by computer-aided design/computer-assisted manufacture technology, such as stereolithography, or manually in a dental laboratory (us...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12056
更新日期:2014-10-01 00:00:00
abstract::An extensive body of experimental and clinical evidence documents the negative impact of chronic psychological stress and depression on the immune system and health. Chronic stress and depression can result in general dysregulation of the immune system, of both cellular and humoral pathways, which may contribute to pa...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12036
更新日期:2014-02-01 00:00:00
abstract::Periodontitis is a complex infectious disease that affects low-income individuals disproportionately. Periodontitis is associated with specific bacterial species and herpesviruses, and successful prevention and treatment of the disease is contingent upon effective control of these pathogens. This article presents an e...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/j.1600-0757.2011.00429.x
更新日期:2012-10-01 00:00:00
abstract::Evidence indicates that periodontal regeneration is an efficacious and predictable procedure for the treatment of isolated and multiple intrabony defects. Meta-analyses from systematic reviews indicate an added benefit, in terms of clinical attachment level gain, when demineralized freeze-dried bone allograft, barrier...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12048
更新日期:2015-06-01 00:00:00
abstract::This paper focuses on plaque control and the management of gingivitis in adults and summarizes the evidence of commercially available dentifrices as gathered from existing systematic reviews. Three internet sources were used to search for appropriate papers (up to and including February 2017). The search strategy was ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12257
更新日期:2019-02-01 00:00:00
abstract::Dentists need to make daily decisions regarding patient care, and these decisions should essentially be scientifically sound. Evidence-based dentistry is meant to empower clinicians to provide the most contemporary treatment. The benefits of applying the evidence-based method in clinical practice include application o...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.2011.00437.x
更新日期:2012-06-01 00:00:00
abstract::Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Since the 1990s, multiple epidemiologic, experimental...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12344
更新日期:2020-06-01 00:00:00
abstract::The periodontium is a very dynamic organ that responds rapidly to mechanical and chemical stimuli. It is very complex in that it is composed of two hard tissues (cementum and bone) and two soft connective tissues (periodontal ligament and gingiva). Together these tissues are defined by the molecules expressed by the r...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/prd.12037
更新日期:2013-10-01 00:00:00
abstract::This paper is aimed to present a biomaterials perspective in implant therapy that fosters improved bone response and long-term biomechanical competence from surgical instrumentation to final prosthetic rehabilitation. Strategies to develop implant surface texturing will be presented and their role as an ad hoc treatme...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12288
更新日期:2019-10-01 00:00:00
abstract::This chapter affirms that drugs and medicaments may have a profound effect on the periodontal structures. In some instances, such as drug-induced melanosis, the effect may be insignificant to the health of the patient. In other circumstances, drug-induced disorders may initiate painful, destructive disease processes t...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1998.tb00136.x
更新日期:1998-10-01 00:00:00
abstract::Periodontal diseases are chronic inflammatory, multifactorial diseases where the major triggering factors for disease onset are bacteria and their toxins, but the major part of tissue destruction occurs as a result of host response towards the periodontal microbiome. Periodontal microbiome consists of a wide range of ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12355
更新日期:2021-02-01 00:00:00
abstract::In the 1960s and 1970s, implant-supported prostheses based on subperiosteal or blade implants had a poor reputation because of questionable clinical outcomes and lack of scientific documentation. The change to a scientifically sound discipline was initiated by the two scientific pioneers of modern implant dentistry, P...
journal_title:Periodontology 2000
pub_type: 历史文章,杂志文章,评审
doi:10.1111/prd.12185
更新日期:2017-02-01 00:00:00
abstract::Two dominant factors dictate which ingredients are used in formulating toothpaste and mouthwashes. The major one is the type of active ingredient chosen, especially cationic active ingredients such as chlorhexidine; the other factor is the needs of the consumer. Apart from gum health benefits, the consumer expects to ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1997.tb00102.x
更新日期:1997-10-01 00:00:00
abstract::Although the prevalence of tobacco use has declined in some parts of the world, tobacco use remains a persistent and, in some cases, growing problem that will continue to be a fundamental challenge facing dental practitioners in the decades ahead. Dental practitioners have a unique opportunity and professional obligat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12120
更新日期:2016-06-01 00:00:00
abstract::The definition of osteoporosis has evolved beyond low bone mineral density to include impaired bone morphology and matrix properties. As such, the subsequent bone density insufficiencies extend beyond the skeletal risks of fracture and have implications for oral health management patients. As our population ages there...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.2011.00400.x
更新日期:2013-02-01 00:00:00
abstract::Oral mucosal diseases encompass a diverse array of conditions and disorders arising from malignant, potentially malignant, and nonneoplastic processes. Considerable attention has been paid to the former in recent years, much less to the wide range of nonneoplastic disease processes, which constitute a sizeable proport...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12272
更新日期:2019-06-01 00:00:00
abstract::Diagnostic radiology is an essential component of treatment planning in the field of implant dentistry. This narrative review will present current concepts for the use of cone beam computed tomography imaging, before and after implant placement, in daily clinical practice and research. Guidelines for the selection of ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12161
更新日期:2017-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are a family of small, noncoding RNA molecules that negatively regulate protein expression either by inhibiting initiation of the translation of mRNA or by inducing the degradation of mRNA molecules. Accumulating evidence suggests that miRNA-mediated repression of protein expression is of paramount ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12095
更新日期:2015-10-01 00:00:00
abstract::We have compiled, in this Periodontology 2000 review, all Latin American literature on experimental and clinical studies of periodontal plastic procedures. The body of literature on this subject has led to a discussion of the features and treatment outcomes of root-coverage procedures. Over time, knowledge on periodon...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12247
更新日期:2019-02-01 00:00:00
abstract::The primary goal of periodontal therapy is to produce an environment that is conducive to oral health. This is achieved by eliminating the subgingival infection and implementing supragingival plaque control measures designed to prevent the re-colonization of the sulcus. Local etiologic factors, as described above, my ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1046/j.0906-6713.2003.003429.x
更新日期:2004-01-01 00:00:00