Systemic antibiotics in the treatment of periodontitis.

Abstract:

:Despite the fact that several clinical studies have shown additional benefits when certain systemic antibiotics are used as adjuncts to periodontal treatment, clear guidelines for the use of these agents in the clinical practice are not yet available. Basic questions concerning the use of systemic antibiotics to treat periodontitis remain unanswered, such as: which drug(s) should be used; which patients would most benefit from treatment; which are the most effective protocols (i.e. doses and durations); and in which phase of the mechanical therapy should the drug(s) be administered? Although not all of those questions have been directly addressed by controlled randomized clinical trials, recent concepts related to the ecology of periodontal diseases, as well as the major advances in laboratory and clinical research methods that have occurred in the past decade, have significantly broadened our knowledge in this field. This article endeavored to provide a 'state of the art' overview on the use of systemic antibiotics in the treatment of periodontitis, based on the most recent literature on the topic as well as on a compilation of data from studies conducted at the Center of Clinical Trials at Guarulhos University (São Paulo, Brazil) from 2002 to 2012.

journal_name

Periodontol 2000

journal_title

Periodontology 2000

authors

Feres M,Figueiredo LC,Soares GM,Faveri M

doi

10.1111/prd.12075

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

131-86

issue

1

eissn

0906-6713

issn

1600-0757

journal_volume

67

pub_type

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