Abstract:
:Periodontal microbiology has historically been based on an "us against them" paradigm, one that focuses mainly on identifying microbes and viruses that cause disease. However, such a bottom-up approach limits our appreciation of the incredible diversity of this ecosystem and the essential ways in which microbial interactions contribute to health and homeostasis of the subgingival niche. Microbiomics-the science of collectively characterizing and quantifying molecules responsible for the structure, function, and dynamics of a microbial community-has enabled us to study these communities in their natural habitat, thereby revolutionizing our knowledge of host-associated microbes and reconceptualizing our definition of "human." When this systems-biology approach is combined with ecologic principles, it explicates the complex relationship that exist between microbiota and between them and us, the human. In this volume of Periodontology 2000, a group of 12 female scientists take the lead in investigating how metagenomics, genomics, metatranscriptomics, proteomics, metaproteomics, and metabolomics have achieved the following: (a) widened our view of the periodontal microbiome; (b) expanded our understanding of the evolution of the human oral microbiome; (c) shone a light on not just bacteria, but also other prokaryotic and eukaryotic members of the community; (d) elucidated the effects of anthropogenic behavior and systemic diseases on shaping these communities; and (e) influenced traditional patterns of periodontal therapeutics.
journal_name
Periodontol 2000journal_title
Periodontology 2000authors
Kumar PSdoi
10.1111/prd.12373subject
Has Abstractpub_date
2021-02-01 00:00:00pages
8-11issue
1eissn
0906-6713issn
1600-0757journal_volume
85pub_type
杂志文章,评审abstract::This chapter affirms that drugs and medicaments may have a profound effect on the periodontal structures. In some instances, such as drug-induced melanosis, the effect may be insignificant to the health of the patient. In other circumstances, drug-induced disorders may initiate painful, destructive disease processes t...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1998.tb00136.x
更新日期:1998-10-01 00:00:00
abstract::The primary goal of periodontal therapy is to produce an environment that is conducive to oral health. This is achieved by eliminating the subgingival infection and implementing supragingival plaque control measures designed to prevent the re-colonization of the sulcus. Local etiologic factors, as described above, my ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1046/j.0906-6713.2003.003429.x
更新日期:2004-01-01 00:00:00
abstract::There has been immense interest in the uses of saliva in the diagnosis of systemic disease over the past decade and longer because it is recognized that saliva possesses great potential as a diagnostic fluid. In spite of this, the usefulness of saliva in studies of the epidemiology of human disease has still to be pro...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12108
更新日期:2016-02-01 00:00:00
abstract::The periodontium is a very dynamic organ that responds rapidly to mechanical and chemical stimuli. It is very complex in that it is composed of two hard tissues (cementum and bone) and two soft connective tissues (periodontal ligament and gingiva). Together these tissues are defined by the molecules expressed by the r...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/prd.12037
更新日期:2013-10-01 00:00:00
abstract::Oral mucosal diseases encompass a diverse array of conditions and disorders arising from malignant, potentially malignant, and nonneoplastic processes. Considerable attention has been paid to the former in recent years, much less to the wide range of nonneoplastic disease processes, which constitute a sizeable proport...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12272
更新日期:2019-06-01 00:00:00
abstract::The most important development in the epidemiology of periodontitis in the USA during the last decade is the result of improvements in survey methodologies and statistical modeling of periodontitis in adults. Most of these advancements have occurred as the direct outcome of work by the joint initiative known as the Pe...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12323
更新日期:2020-02-01 00:00:00
abstract::Studies ranging from preclinical animal models to human clinical trials support the basic hypothesis that the inhibition of local arachidonic acid metabolites with nonsteroidal anti-inflammatory drugs slows periodontal disease progression. Data on modulation of other host mediators such as cytokines and NO remain rest...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0757.2000.2240112.x
更新日期:2000-10-01 00:00:00
abstract::Periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. Herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. In 26 recent studies from 15 countries, subgingival cyt...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12085
更新日期:2015-10-01 00:00:00
abstract::Translation of experimental data to the clinical setting requires the safety and efficacy of such data to be confirmed in animal systems before application in humans. In dental research, the animal species used is dependent largely on the research question or on the disease model. Periodontal disease and, by analogy, ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12052
更新日期:2015-06-01 00:00:00
abstract::The focus of this review on periodontal self-care will be based primarily on the results of systematic reviews and meta-analyses. Based on the evidence gleaned from systematic reviews, it is notable that most authors of these reviews commented on the relatively small number of trials that could pass the quality-assess...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12012
更新日期:2013-06-01 00:00:00
abstract::Periodontal diseases are chronic inflammatory, multifactorial diseases where the major triggering factors for disease onset are bacteria and their toxins, but the major part of tissue destruction occurs as a result of host response towards the periodontal microbiome. Periodontal microbiome consists of a wide range of ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12355
更新日期:2021-02-01 00:00:00
abstract::Cardiovascular diseases still account for the majority of deaths worldwide, although significant improvements in survival, after being affected by cardiovascular disease, have been achieved in the last decades. Periodontal diseases are also a common global burden. Several studies have shown a link between cardiovascul...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12302
更新日期:2020-06-01 00:00:00
abstract::Although the prevalence of tobacco use has declined in some parts of the world, tobacco use remains a persistent and, in some cases, growing problem that will continue to be a fundamental challenge facing dental practitioners in the decades ahead. Dental practitioners have a unique opportunity and professional obligat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12120
更新日期:2016-06-01 00:00:00
abstract::The signaling network involved in the pathogenesis of periodontal disease is not yet fully understood. This review aims to describe possible mechanisms through which the bacterial modulators may be linked directly or indirectly to the process of alveolar bone loss in periodontitis. From the late 1970s to present, new ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12160
更新日期:2018-02-01 00:00:00
abstract::In the 1960s and 1970s, implant-supported prostheses based on subperiosteal or blade implants had a poor reputation because of questionable clinical outcomes and lack of scientific documentation. The change to a scientifically sound discipline was initiated by the two scientific pioneers of modern implant dentistry, P...
journal_title:Periodontology 2000
pub_type: 历史文章,杂志文章,评审
doi:10.1111/prd.12185
更新日期:2017-02-01 00:00:00
abstract::Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Since the 1990s, multiple epidemiologic, experimental...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12344
更新日期:2020-06-01 00:00:00
abstract::Surgical procedures of the oral cavity can be performed by a number of dental specialists and clinicians. Because of the limited number of surgical procedures that can be performed inside the oral cavity, the boundaries between specialties may become indistinct and lead to confusion for general dentists in terms of pa...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12196
更新日期:2017-06-01 00:00:00
abstract::Evidence indicates that periodontal regeneration is an efficacious and predictable procedure for the treatment of isolated and multiple intrabony defects. Meta-analyses from systematic reviews indicate an added benefit, in terms of clinical attachment level gain, when demineralized freeze-dried bone allograft, barrier...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12048
更新日期:2015-06-01 00:00:00
abstract::Two dominant factors dictate which ingredients are used in formulating toothpaste and mouthwashes. The major one is the type of active ingredient chosen, especially cationic active ingredients such as chlorhexidine; the other factor is the needs of the consumer. Apart from gum health benefits, the consumer expects to ...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.1997.tb00102.x
更新日期:1997-10-01 00:00:00
abstract::Periodontitis is a complex infectious disease that affects low-income individuals disproportionately. Periodontitis is associated with specific bacterial species and herpesviruses, and successful prevention and treatment of the disease is contingent upon effective control of these pathogens. This article presents an e...
journal_title:Periodontology 2000
pub_type: 杂志文章
doi:10.1111/j.1600-0757.2011.00429.x
更新日期:2012-10-01 00:00:00
abstract::This review has highlighted the importance of standardizing future investigations to enable more meaningful interstudy comparisons to be made. This report also makes recommendations for factors that should be considered and incorporated into future investigations, both in vitro and in vivo, in order to achieve more st...
journal_title:Periodontology 2000
pub_type: 历史文章,杂志文章,评审
doi:10.1111/j.1600-0757.2009.00300.x
更新日期:2009-01-01 00:00:00
abstract::We have compiled, in this Periodontology 2000 review, all Latin American literature on experimental and clinical studies of periodontal plastic procedures. The body of literature on this subject has led to a discussion of the features and treatment outcomes of root-coverage procedures. Over time, knowledge on periodon...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12247
更新日期:2019-02-01 00:00:00
abstract::Different mechanisms have been hypothesized to explain the increase in prevalence and severity of periodontitis in older adults, including shifts in the periodontal microbiota. However, the actual impact of aging on the composition of subgingival biofilms remains unclear. In the present article, we provide an overview...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12136
更新日期:2016-10-01 00:00:00
abstract::A number of systemic disorders increase a patient's susceptibility to destructive periodontitis and have impacts on periodontal disease progression and severity. The underlying factors are usually genetic and are mainly related to alterations in the immune response and in certain endocrine functions, leading to variou...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12015
更新日期:2014-06-01 00:00:00
abstract::The discovery of neutrophil extracellular traps in 2004 opened a fascinating new chapter in immune-mediated microbial killing. Brinkman et al. demonstrated that neutrophils, when catastrophically stimulated, undergo a novel form of programmed cell death (neutrophil extracellular trap formation) whereby they decondense...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12025
更新日期:2013-10-01 00:00:00
abstract::Dentists need to make daily decisions regarding patient care, and these decisions should essentially be scientifically sound. Evidence-based dentistry is meant to empower clinicians to provide the most contemporary treatment. The benefits of applying the evidence-based method in clinical practice include application o...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0757.2011.00437.x
更新日期:2012-06-01 00:00:00
abstract::There is increasing public interest in natural or herbal-based healthcare products. This trend is not only visible in supermarkets and dental practices, but also in the scientific world. An improving number of clinical trials are being conducted to validate the claims made about these products in regards to periodonta...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12339
更新日期:2020-10-01 00:00:00
abstract::Despite the fact that several clinical studies have shown additional benefits when certain systemic antibiotics are used as adjuncts to periodontal treatment, clear guidelines for the use of these agents in the clinical practice are not yet available. Basic questions concerning the use of systemic antibiotics to treat...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12075
更新日期:2015-02-01 00:00:00
abstract::For computer-guided surgery a static surgical guide is used that transfers the virtual implant position from computerized tomographic data to the surgical site. These guides are produced by computer-aided design/computer-assisted manufacture technology, such as stereolithography, or manually in a dental laboratory (us...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12056
更新日期:2014-10-01 00:00:00
abstract::An extensive body of experimental and clinical evidence documents the negative impact of chronic psychological stress and depression on the immune system and health. Chronic stress and depression can result in general dysregulation of the immune system, of both cellular and humoral pathways, which may contribute to pa...
journal_title:Periodontology 2000
pub_type: 杂志文章,评审
doi:10.1111/prd.12036
更新日期:2014-02-01 00:00:00