Abstract:
OBJECTIVE:The aim of this study is to evaluate the impact of multiple pregnancies, maternal obesity, and preeclampsia on the effect of antenatal steroids on neonatal respiratory distress syndrome (RDS). STUDY DESIGN:The retrospective cohort study was performed in a level III maternity ward. Population was composed of mother-infant pairs. We included inborn infants < 34 weeks gestation, hospitalized in our neonatal intensive care unit, and mothers delivering before 34 weeks gestation and hospitalized before delivery. Primary measurement outcome was RDS. RESULTS:A total of 1,173 subjects were included: 535 mothers and 638 preterm infants. Antenatal corticosteroid (ACS) doses and pulmonary surfactant doses were negatively correlated (r = -0.15, p = 0.0002). Multiple logistic regression: lower gestational age and cesarean section were significantly associated with RDS in single pregnancies (odds ratio [OR], 95% confidence interval [CI]): 2.0 (1.7-2.4) and 3.6 (1.8-7.1), respectively; only gestational age was associated with RDS in twin or higher-order pregnancies: 2.7 (1.9-4.1) and 1.8 (0.6-5.4), respectively. Preterm infants of obese women did not receive more pulmonary surfactant than other preterm infants: OR = 0.67 (0.13-1.40), neither did those born to women with hypertension or preeclampsia. CONCLUSION:More ACS doses were associated with less pulmonary surfactant doses. Cesarean section and low gestational age increased the risk of RDS, independently from ACS administration, but maternal obesity and multiple pregnancies did not.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Claire L,Vieux Rdoi
10.1055/s-0035-1548537subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1070-7issue
11eissn
0735-1631issn
1098-8785journal_volume
32pub_type
杂志文章abstract::A patient with a homozygous marital partner had three progressively less seriously involved RH-positive babies after a fetal demise due to erythroblastosis. Only the first of the three required fetal transfusions. All were Rh genotypically identical. The case is presented for interest and to illustrate an exception to...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999655
更新日期:1988-01-01 00:00:00
abstract::We evaluated the efficacy, safety, and biological mechanisms of digoxin immune Fab (DIF) treatment of severe preeclampsia. Fifty-one severe preeclamptic patients were randomized in double-blind fashion to DIF ( N = 24) or placebo ( N = 27) for 48 hours. Primary outcomes were change in creatinine clearance (CrCl) at 24...
journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0030-1249762
更新日期:2010-09-01 00:00:00
abstract::It has been suggested that vibroacoustic stimulation might be stressful to the fetus. The present study was designed to evaluate whether the stimulus induces passage of meconium in labor. Patients in labor at term with healthy fetuses and intact membranes were randomized to a vibroacoustic stimulation or sham test. Th...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-994297
更新日期:1996-02-01 00:00:00
abstract::Premature closure of the foramen ovale is a rare cardiac anomaly. Severe right-sided heart failure accounts for the hepatomegaly, ascites, pleural and pericardial effusions, and generalized edema of these hydropic fetuses. Premature closure of the foramen ovale should be a part of the differential diagnosis when unexp...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994616
更新日期:1994-11-01 00:00:00
abstract::It is well established that ultrasound measurement of femur length and biparietal diameter are comparably accurate estimators of gestational age when obtained in the first half of pregnancy. Both estimators, however, become less accurate later in pregnancy. The present study compares the relative accuracy of these est...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999837
更新日期:1986-04-01 00:00:00
abstract::Endotracheal instillation and subsequent suctioning produces fluctuations of intracranial pressure (ICP), mean arterial pressure (MAP), and cerebral perfusion pressure (CPP) in sick preterm infants. In an attempt to observe if these fluctuations could be minimized using sedation, we studied a group of seven sick mecha...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999841
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVE:We sought to determine if maternal prepregnancy body mass index (BMI) is a risk factor for neonatal respiratory morbidity and to determine if increasing BMI decreased the efficacy of betamethasone (BMZ). STUDY DESIGN:This was a secondary analysis of the Antenatal Late Preterm Steroids trial, double-blind, ra...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0039-1696644
更新日期:2020-03-01 00:00:00
abstract::Our objective was to compare the incidence of recurrent spontaneous preterm delivery (SPTD) in patients with cervical cerclage treated with weekly 17 alpha-hydroxyprogesterone caproate (17P) injections versus daily outpatient nursing surveillance (ONS) without 17P. Included in this retrospective cohort study were sing...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2008-1064935
更新日期:2008-05-01 00:00:00
abstract::We present a case of congenital parvovirus B19 infection in a term neonate manifested with isolated massive hydrothorax and mild anemia. Parvovirus B19 DNA was detected in maternal and neonatal blood as well as in pleural fluid despite lack of suggestive serology. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1085621
更新日期:2008-10-01 00:00:00
abstract::The objective of this paper is to determine whether acyclovir suppression provides a greater cost savings over no medical therapy in the management of recurrent genital herpes (HSV) in pregnancy. Estimates of the risk of HSV recurrence and cesarean delivery rates in acyclovir-treated and -untreated patients and freque...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993900
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To develop a model to predict cesarean-associated red blood cell transfusion. STUDY DESIGN:Secondary analysis of all cesarean deliveries in the Maternal-Fetal Medicine Units Network Cesarean Registry. Using a split-sample technique, the derivation group was used to identify associated factors and build predi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1678604
更新日期:2019-07-01 00:00:00
abstract::The primary objective of this study was to determine whether having the sickle cell trait is independently associated with preeclampsia. We performed a retrospective cohort study of 1998 pregnant patients who either did or did not have the sickle cell trait. All patients were screened for the sickle trait using the "S...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2003-37953
更新日期:2003-01-01 00:00:00
abstract::A 27-year-old primigravida women was referred for ultrasound studies at 32 weeks' gestation because of the suspicion of fetal ventriculomegaly. Sonographic examination of the fetal brain found a marked shift of the midline, with enlarged left hemisphere and ipsilateral occipital horn, and abnormal convolutions. A 3500...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999330
更新日期:1991-01-01 00:00:00
abstract::Numerous diagnostic pitfalls were noted among 6 infants with infradiaphragmatic total anomalous pulmonary venous drainage, including prolonged moderate respiratory distress in 2 infants, normal cardiac examination in 2, normal electrocardiograms in 2, arterial PO2 in excess of 100 torr in 3 cases, right radial/umbilic...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-1000010
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE: This article aims to compare long-term neurodevelopmental and health outcomes of twins born at 34 weeks or later, based on the presence of small for gestational age (SGA). STUDY DESIGN: This study is a mail-based survey of twin gestations delivered by a single practice. We compared twins with and without SG...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1607043
更新日期:2018-02-01 00:00:00
abstract::The Diabetes in Pregnancy Study Group of North America (DPSG-NA) was founded in 1997 in San Antonio, Texas, out of the recognition that the field of maternal-fetal medicine should support and conduct research to address the specialized needs of pregnant women with type 1, type 2, or gestational diabetes mellitus. Sinc...
journal_title:American journal of perinatology
pub_type: 历史文章,杂志文章
doi:10.1055/s-0036-1585082
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:This study aims to identify risk factors for cesarean delivery (CD) surgical site infection (SSI). study design: Retrospective analysis of 2,739 CDs performed at the University of Pittsburgh in 2011. CD SSIs were defined using National Healthcare Safety Network (NHSN) criteria. Chi-square test and t-test were...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1563548
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins w...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1677472
更新日期:2019-12-01 00:00:00
abstract::Seventy premature infants (birthweight 1.75 kg or less, gestational age 33 weeks or less) with hemoglobin less than 10 g/dL and hematocrit less than 30% were studied and randomly divided into three groups. All of them received oral elemental iron 3 mg/kg/day and vitamin E 5 mg/kg/day during the study period. Recombina...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-994483
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:Recent guidelines for neonatal cardiopulmonary resuscitation emphasize the importance of adequate ventilation. In cases of failed resuscitation with positive pressure ventilation, tracheal intubation and chest compressions are recommended. The present study compared the utility of the Miller laryngoscope (Mil...
journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0034-1395482
更新日期:2015-07-01 00:00:00
abstract::Liposomal amphotericin B L-Amp B, a novel formulation of Amp B, is effective for the treatment of invasive fungal infections in children and adults and is associated with less toxicity than the conventional preparation. Data on the use of L-Amp B in neonates is scarce. We describe the clinical course of two premature ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994337
更新日期:1997-10-01 00:00:00
abstract::Objective There is limited data regarding the use of oral hypoglycemic agents (OHAs) in pregnant women with type 2 diabetes mellitus (T2DM). Study Design This was a retrospective cohort study of women with T2DM who were treated with OHA or insulin from the first trimester onward. Bivariate and multivariate logistic re...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1597625
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of first-trimester uterine artery Doppler in the prediction of recurrent preeclampsia (PE). METHODS:Uterine artery pulsatility index (UtPI) was measured at 11 to 13 weeks' gestation in 1,810 women with singleton pregnancies who had developed PE in a previous pregnancy. They were categori...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0033-1338172
更新日期:2014-02-01 00:00:00
abstract::In studying the effects of amniotic fluid on bacterial growth in a laboratory model, we noted that the pH of the fluid appeared to exert an independent effect. This study was designed to test the ability to control the growth of Escherichia coli in amniotic fluid simply by controlling two important growth conditions, ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994674
更新日期:1992-03-01 00:00:00
abstract::Interest in centralized monitoring in labor and delivery units is growing because it affords the opportunity to monitor multiple patients simultaneously. However, a long history of research on sustained attention reveals these types of monitoring tasks can be problematic. The goal of the present experiment was to exam...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1268718
更新日期:2011-06-01 00:00:00
abstract::We evaluated the clinical significance of late decelerations (LD) of intrapartum fetal heart rate (FHR) monitoring to detect low pH (< 7.1) in low-risk pregnancies. We selected two secondary and two tertiary-level institutions where 10,030 women delivered. Among them, 5522 were low-risk pregnancies. The last 2 hours o...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-837272
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Despite advances in management of persistent pulmonary hypertension of the newborn (PPHN), the risk of mortality and adverse neurological sequelae remains high. Characterizing variation in practices is a crucial step toward improved patient outcome. OBJECTIVE:Evaluate intensive care practices in Canada and ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1310523
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:Adding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also redu...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1679914
更新日期:2019-07-01 00:00:00
abstract::An abdominal gunshot wound in pregnancy warrants prompt surgical exploration but does not mandate uterine evacuation. Despite an entry and exit bullet wound to the uterus an apparent desire for pregnancy termination, a conservative approach was adopted with primary repair of the uterus, in conjunction with surgical re...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999691
更新日期:1988-07-01 00:00:00
abstract::Trichosporon beigelii is an uncommon cause of sepsis in low-birth-weight infants. We present two cases of neonatal trichosporonosis and two cases of neonatal trichosporon colonization to familiarize neonatologists with this entity and to discuss management considerations. A 23-week-gestation male developed clinical ev...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994109
更新日期:1997-02-01 00:00:00