Abstract：
:The primary objective of this study was to determine whether having the sickle cell trait is independently associated with preeclampsia. We performed a retrospective cohort study of 1998 pregnant patients who either did or did not have the sickle cell trait. All patients were screened for the sickle trait using the "Sickledex" test. Data on neonatal and maternal outcome, including preeclampsia, and potential confounding variables were abstracted from medical records. Unadjusted, stratified, and multiple logistic regression analyses were used to identify interactions, and confounding between multiple variables and the association between sickle cell trait and preeclampsia. With an anticipated 6.5% rate of preeclampsia, and alpha = 0.05, this cohort study has 80% power to detect a relative risk (RR) of 2.3 for preeclampsia. Univariate analysis revealed that the two cohorts were similar with regard to primiparity, maternal age, chronic diseases, birth weight, and gestational age at delivery, but the sickle cell trait cohort was more likely to have gestational diabetes and had a higher mean body mass index (BMI). In the univariate analysis, the sickle cell trait cohort was not at increased risk for preeclampsia [unadjusted RR = 0.5, 95% CI (0.2-1.6)]. After controlling for potential confounding variables with logistic regression analysis, sickle trait was not independently associated with preeclampsia [adjusted RR = 0.5, 95% CI (0.2- 1.6)]. In contrast to prior work, these data suggest that the sickle cell trait is not an independent risk factor for preeclampsia or postpartum complications. In fact, the data are more consistent with the sickle trait being protective for developing preeclampsia.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Stamilio DM,Sehdev HM,Macones GAdoi
10.1055/s-2003-37953subject
Has Abstractpub_date
2003-01-01 00:00:00pages
41-8issue
1eissn
0735-1631issn
1098-8785journal_volume
20pub_type
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994638
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0031-1285827
更新日期：2012-04-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993872
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999837
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journal_title：American journal of perinatology
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doi：10.1055/s-2007-999893
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journal_title：American journal of perinatology
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doi：10.1055/s-2007-994468
更新日期：1995-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章
doi：10.1055/s-2007-999685
更新日期：1988-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1586500
更新日期：2016-11-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
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journal_title：American journal of perinatology
pub_type： 杂志文章,随机对照试验
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更新日期：2010-09-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0030-1270113
更新日期：2011-06-01 00:00:00
abstract：:With the increasing survival of extremely premature infants there is a large number of them who are developing chronic lung disease (CLD), but the severity of the lung damage is considerably less than that observed in the classic form of bronchopulmonary dysplasia (BPD). Because many of these infants have only a mild ...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-2001-12940
更新日期：2001-01-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-970079
更新日期：2007-02-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1710009
更新日期：2020-05-23 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0038-1660463
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:This study aims to determine if transabdominal (TA) cervical length may be used to rule out a short cervix on transvaginal (TV) ultrasound. STUDY DESIGN:We conducted a prospective cohort study of women undergoing routine anatomic survey at 17 to 23 weeks gestation. TA and TV cervical length measurements were...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0035-1566308
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to estimate the contemporary national rate of severe maternal morbidity (SMM) and its associated hospital cost during delivery hospitalization. STUDY DESIGN:We conducted a retrospective study identifying all delivery hospitalizations in the United States between 2011 and 2012....
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1649481
更新日期：2018-11-01 00:00:00
