Digoxin immune fab treatment for severe preeclampsia.

Abstract:

:We evaluated the efficacy, safety, and biological mechanisms of digoxin immune Fab (DIF) treatment of severe preeclampsia. Fifty-one severe preeclamptic patients were randomized in double-blind fashion to DIF ( N = 24) or placebo ( N = 27) for 48 hours. Primary outcomes were change in creatinine clearance (CrCl) at 24 to 48 hours and antihypertensive drug use. Serum sodium pump inhibition, a sequela of endogenous digitalis-like factors (EDLF), was also assessed. CrCl in DIF subjects was essentially unchanged from baseline versus a decrease with placebo (-3 +/- 10 and -34 +/- 10 mL/min, respectively, P = 0.02). Antihypertensive use was similar between treatments (46 and 52%, respectively, P = 0.7). Serum sodium pump inhibition was decreased with DIF compared with placebo at 24 hours after treatment initiation (least squares mean difference, 19 percentage points, P = 0.03). DIF appeared to be well tolerated. These results suggest DIF prevents a decline in renal function in severe preeclampsia by neutralizing EDLF. Sodium pump inhibition was significantly improved. Further research is warranted.

journal_name

Am J Perinatol

authors

Adair CD,Buckalew VM,Graves SW,Lam GK,Johnson DD,Saade G,Lewis DF,Robinson C,Danoff TM,Chauhan N,Hopoate-Sitake M,Porter KB,Humphrey RG,Trofatter KF,Amon E,Ward S,Kennedy L,Mason L,Johnston JA

doi

10.1055/s-0030-1249762

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

655-62

issue

8

eissn

0735-1631

issn

1098-8785

journal_volume

27

pub_type

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