Abstract:
OBJECTIVE:To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined. METHODS:Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk women to prevent pregnancy associated hypertension. Women between 9 and 16 weeks with data for WHR and BMI were analyzed for GDM (n = 2,300). Those with fasting glucose and insulin between 22 and 26 weeks (n = 717) were analyzed for IR by homeostatic model assessment of IR (normal, ≤ 75th percentile). WHR and BMI were categorized as normal (WHR, < 0.80; BMI, < 25 kg/m(2)); overweight (WHR, 0.8-0.84; BMI, 25-29.9 kg/m(2)); and obese (WHR, ≥ 0.85; BMI ≥ 30 kg/m(2)). Receiver operating characteristic curves and logistic regression models were used. RESULTS:Compared with normal, the risks of GDM or IR were higher in obese by BMI or WHR. The subgroup with obesity by WHR but not by BMI had no increased risk of GDM. BMI was a better predictor of IR (area under the curve [AUC]: 0.71 [BMI], 0.65 [WHR], p = 0.03) but similar to WHR for GDM (AUC: 0.68 [BMI], 0.63 [WHR], p = 0.18). CONCLUSION:Increased WHR and BMI in early pregnancy are associated with IR and GDM. BMI is a better predictor of IR compared with WHR. Adding WHR to BMI does not improve its ability to detect GDM or IR.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Basraon SK,Mele L,Myatt L,Roberts JM,Hauth JC,Leveno KJ,Varner MW,Wapner RJ,Thorp JM Jr,Peaceman AM,Ramin SM,Sciscione A,Tolosa JE,Sorokin Y,Eunice Kennedy Shriver National Institute of Child Health and Human Development Matedoi
10.1055/s-0035-1562928subject
Has Abstractpub_date
2016-01-01 00:00:00pages
114-21issue
1eissn
0735-1631issn
1098-8785journal_volume
33pub_type
杂志文章,多中心研究,随机对照试验abstract::The estimation of plasma bilirubin concentration in neonates, using a transcutaneous, noninvasive jaundice meter, is significantly affected by many factors, such as gestational age, birthweight, phototherapy, and skin pigmentation. In an attempt to minimize the influence of skin color and hence circumvent the need for...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2008-1040751
更新日期:1994-05-01 00:00:00
abstract::We studied the relationships between fetal hemoglobin concentration, acid base status, and lactate concentration in umbilical venous and fetal heart blood in 157 fetuses affected by blood group incompatibility who had been exposed for 214 fetal blood sampling procedures (cordocentesis in 153 and intracardiac puncture ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994524
更新日期:1994-01-01 00:00:00
abstract::Multiple gestations are increasing in frequency secondary to assisted reproductive technologies; therefore, it will become increasingly important to know how to manage a multiple pregnancy in which an in utero fetal death has occurred. This case report describes the spontaneous resolution of maternal hypofibrinogenemi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994628
更新日期:1993-11-01 00:00:00
abstract::We report about two newborns with sudden onset of inability of mechanical ventilation due to transient chest wall rigidity after fentanyl i.v. bolus of 2 and 4 microg/kg, respectively, resulting in severe hypoxemia and secondary bradycardia. A third case developed a rigidity of the tongue after fentanyl bolus, which c...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-7289
更新日期:2000-01-01 00:00:00
abstract::Chorioamnionitis contributes to neonatal and maternal morbidity and mortality. We aimed to evaluate of the impact of clinical and histological chorioamnionitis on mortality and morbidity of preterm infants. Maternal and neonatal data were collected in a retrospective cohort of preterm infants less than 30 weeks' gesta...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1321501
更新日期:2013-01-01 00:00:00
abstract::Rh disease has largely disappeared as a result of prophylaxis with anti-D. However, the cases that remain are more complicated with a combination of novel challenges with regard to in utero management with transfusion and its effects on the course of the neonate, both early and late. Thrombocytopenia in the neonate ca...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2003-45392
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Neonatal presentation of vein of Galen aneurysmal malformations (VGAMs) complicated by cardiac failure and pulmonary hypertension is frequently associated with a poor prognosis. Interventional neuroradiology with embolization can offer a chance for survival, although neurological damage can represent a limit...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1666813
更新日期:2019-01-01 00:00:00
abstract::Presented are three cases of fetal death, all of which occurred within 3 days of a normal biophysical profile. Despite the excellent record of this antepartum test in predicting fetal well-being, there is a low incidence of false-negative tests; increasing the frequency of testing will not prevent all false-negative t...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999352
更新日期:1991-03-01 00:00:00
abstract::The objectives of this study are to assess the incidence of congenital complete heart block (CCHB) in pregnant women who are anti-Ro and/or La positive. Between January, 1988 and July 1997, 118 pregnancies in 105 women were assessed by fetal echo at 18, 24, and 32 weeks' gestation. Of these 105, 96 had no history of a...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2002-23555
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE: The study aims to assess the impact on neurodevelopmental outcomes of a prolonged hemodynamically significant patent ductus arteriosus (PDA) after a conservative treatment. STUDY DESIGN: This involves the study of two cohorts of preterm infants 23 to 29 weeks gestation, before (n = 29) and after (n = 54) a ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1697674
更新日期:2019-10-10 00:00:00
abstract::The objective of this article is to prospectively investigate the efficacy of amnioinfusion as a means to reduce febrile morbidity in pregnancies complicated by chorioamnionitis. All laboring patients with a temperature > or =100.1 degrees F were approached for study participation. Exclusion criteria included amnionit...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-994085
更新日期:1998-01-01 00:00:00
abstract::Primary genital herpes simplex virus (HSV) infection in pregnancy is associated with an increased risk of vertical transmission to the fetus, especially with rupture of membranes. Two cases of primary herpes and two cases of recurrent herpes in pregnancy with preterm premature rupture of membranes and expectant manage...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2002-33090
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE: Sepsis is a major cause of neonatal mortality. The gold standard for diagnosis is blood culture which suffers from low sensitivity and huge turn-around time. Flow cytometry has been extensively applied to malignant disorders and is an upcoming tool for diagnosis of nonmalignant disorders due to its rapidity ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1718370
更新日期:2020-09-29 00:00:00
abstract::This investigation was undertaken to determine whether histologic examination of the placenta contributed to a better understanding of the cause of intrauterine fetal growth retardation. Placentas were examined of 151 liveborn infants whose birthweights were in the lower 10th percentile for gestational age. One or mor...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999546
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE: Potentially avoidable maternity complications (PAMCs) have been validated as an indicator of access to quality prenatal care. African-American mothers have exhibited a higher incidence of PAMCs, which has been attributed to unequal health coverage. The objective of this study was to assess if racial disparit...
journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-01-27 00:00:00
abstract::Periventricular leukomalacia, a condition characterized by hpoxic-ischemic infarction of deep cerebral white matter, can now be recognized by cranial sonography. The case presented here demonstrates the association of periventricular leukomalacia present at birth with intrauterine paroxysmal supraventricular tachycard...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999826
更新日期:1986-01-01 00:00:00
abstract::Acute mitral regurgitation due to ruptured chordae tendineae is a dramatic and life-threatening clinical situation. Rarely does this complication occur during pregnancy. We present a case of a 30-year-old woman in week 31 of her pregnancy who developed acute mitral regurgitation, secondary to bacterial endocarditis an...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994418
更新日期:1995-03-01 00:00:00
abstract::We present an unusual case, in which a woman presenting with markedly decreased fetal movements at 29 weeks gestation following a recent increase in fundal height was noted sonographically to have fetal hydrops consisting of scalp edema, marked hepatomegaly, ascites, and polyhydramnios. No lethal structural congenital...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993933
更新日期:1998-04-01 00:00:00
abstract::Placental pathology in preeclampsia (PE) and intrauterine growth retardation (IUGR) is associated with alterations of the placental epidermal growth factor receptor (EGFR). It is encoded by a single gene, which gives rise to two different full-length transcripts and one putative truncated transcript in the placenta. T...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993890
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994407
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate if maternal serum hormones along the maternal-fetal hypothalamic-pituitary-adrenal (HPA) axis, when drawn prior to labor induction, differed between women who delivered vaginally and those who underwent cesarean. STUDY DESIGN:This was a prospective observational study at a single...
journal_title:American journal of perinatology
pub_type: 杂志文章
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994649
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:This study aims to develop a scoring system for the prediction of bronchopulmonary dysplasia (BPD). METHODS:Medical records of 652 infants whose gestational age and birth weight were below 32 weeks and 1,500 g, respectively, and who survived beyond 28th postnatal day were reviewed retrospectively. Logistic r...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1393935
更新日期:2015-06-01 00:00:00
abstract::Nine patients with posthemipelvectomy with subsequent delivery of 13 living children are reported in the world's literature. This radical procedure is possible only in a modern age of intensive medical and surgical support. Additional cases can be expected in the future. We present two additional patients and three ch...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-999616
更新日期:1989-07-01 00:00:00
abstract::We investigated the correlation of fetal heart rate patterns and fetal acid-base findings with the occurrence of early periventricular/intraventricular hemorrhage and variants. Ninety-five consecutive singleton neonates with birthweights less than or equal to 2000 gm were investigated. One-third of them showed early p...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999819
更新日期:1986-01-01 00:00:00
abstract::Phototherapy is one of the most common therapeutic interventions in modern neonatal medicine. Analysis of physiological responses to phototherapy requires understanding the physical effects of incident light under different modes of environmental control. In this study, we tested the effect of initiation of photothera...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994402
更新日期:1995-01-01 00:00:00
abstract::The pregnant woman with idiopathic thrombocytopenic purpura (ITP) and her fetus-neonate present a number of challenging issues for both the perinatologist and neonatologist. A review of these issues within a single format is helpful because of the widely scattered nature of the pertinent information in the medical lit...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-1000014
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE: The study objective was to assess the correlation between hypernatremia during the first week of life and neurodevelopmental outcomes at 18 months of corrected age in premature infants. STUDY DESIGN: A retrospective observational study of preterm infants born at less than 32 weeks of gestation who had a neu...
journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2020-09-24 00:00:00
abstract::Tuberous sclerosis complex (TSC) is an autosomal-dominant phakomatosis that can result in cardiac and central nervous system lesions and may adversely impact fetal and maternal health. We report a case of a 19-year-old primagravida with TSC whose pregnancy was complicated by preeclampsia, preterm labor, and fetal demi...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-861572
更新日期:2005-02-01 00:00:00
abstract::The occurrence of preterm labor is not uncommon in the pregnant quadriplegic. Early diagnosis is hampered by the inability of most quadriplegics to sense uterine contractions in the usual way. A patient we recently treated for preterm labor learned to recognize contractions by the associated symptoms of autonomic hype...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999845
更新日期:1986-04-01 00:00:00