Abstract:
OBJECTIVE: The study objective was to assess the correlation between hypernatremia during the first week of life and neurodevelopmental outcomes at 18 months of corrected age in premature infants. STUDY DESIGN: A retrospective observational study of preterm infants born at less than 32 weeks of gestation who had a neurodevelopmental assessment with the Bayley scales of infant and toddler development III at 18 ± 6 months of corrected age. Serum sodium levels from birth through 7 days of life were collected. The study cohort was divided into two groups: infants with a peak serum sodium of >145 mmol/L (hypernatremia group) and infants with a peak serum sodium level of <145 mmol/L (no hypernatremia group). Prenatal, intrapartum, and postnatal hospital course and neurodevelopmental data at 18 ± 6 months were collected. Logistic regression analysis was used to assess the correlation between neonatal hypernatremia and neurodevelopment with adjustment for selected population characteristics. RESULTS: Eighty-eight preterm infants with complete neurodevelopmental outcome data at 18 ± 6 months of corrected gestational age were included in the study. Thirty-five neonates were in the hypernatremia group and 53 were in the no hypernatremia group. Maternal and neonatal characteristics were similar between the two groups except that the hypernatremia group had a significantly lower average birth weight and gestational age. Comparison of the mean neurodevelopmental scores between the two groups showed that patients in the hypernatremia group as compared with those in the no hypernatremia group had significantly lower neurodevelopmental scaled scores in the fine motor domain (p = 0.01). This difference remained significant (p = 0.03, odds ratio [OR] = 0.8, 95% confidence interval [CI]: 0.6-0.97) when adjusted for birth weight and gestational age. CONCLUSION: Preterm infants born at less than 32 weeks of gestation with hypernatremia in the first week of life have lower fine motor scores at 18 months of corrected age. KEY POINTS:· Hypernatremia is a common electrolyte disturbance in preterm neonates.. · Hypernatremia may be associated with long-term neurodevelopmental outcomes in preterm infants.. · Hypernatremia is a potentially modifiable risk factor..
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Howell HB,Lin M,Zaccario M,Kazmi S,Sklamberg F,Santaniello N,Wachtel Edoi
10.1055/s-0040-1716845subject
Has Abstractpub_date
2020-09-24 00:00:00eissn
0735-1631issn
1098-8785pub_type
杂志文章abstract::With the increasing survival of extremely premature infants there is a large number of them who are developing chronic lung disease (CLD), but the severity of the lung damage is considerably less than that observed in the classic form of bronchopulmonary dysplasia (BPD). Because many of these infants have only a mild ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2001-12940
更新日期:2001-01-01 00:00:00
abstract::The combination of multicystic kidney and crossed ectopia is very rare. In most of the affected children, diagnosis has been made postnatally by ultrasonographic examination to evaluate a palpated abdominal mass. We describe the third male newborn reported in the literature with a prenatally diagnosed crossed ectopic ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-994073
更新日期:1998-08-01 00:00:00
abstract::The most frequently used set of gestational age-birth weight curves in the United States is the Colorado (C) standard published in 1963. To investigate the usefulness of this standard in an urban population at sea level, we examined the birth weight vs gestational age data from 56,675 singleton liveborn infants born b...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999785
更新日期:1987-07-01 00:00:00
abstract::The purpose of this study was to examine factors that were associated with uterine rupture in patients attempting vaginal birth after cesarean delivery. We analyzed the results of all patients attempting vaginal birth after cesarean delivery between September 1996 to December 1999 at a single institution using a conte...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-828608
更新日期:2004-05-01 00:00:00
abstract::We present an unusual case of a primigravida with a viable cervical pregnancy diagnosed by transvaginal ultrasound and magnetic resonance imaging. Staggered conservative therapeutic measures included systemic high-dose Methotrexate with Folinic acid rescue followed by bilateral embolization of the uterine arteries in ...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2003-42341
更新日期:2003-07-01 00:00:00
abstract::The aim of this study was to determine the risk of respiratory distress syndrome (RDS) and neonatal death (NND) in relation to birth weight in preterm neonates. A group of 255 singleton preterm neonates born at 22-36 weeks were examined. The mean birth weight for each gestational week was estimated from a fitted curve...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994327
更新日期:1997-10-01 00:00:00
abstract::A fiber-enriched diabetic diet that contained a modest increase in dietary fiber and a commercially available fiber supplement was studied in pregnant diabetic women for its potential glucose-lowering effects. Noninsulin-requiring gestational diabetic patients were placed on a fiber-enriched diet of increasing fiber c...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-994738
更新日期:1993-07-01 00:00:00
abstract::Pleural effusion is not an uncommon complication of percutaneous intravenous catheters in neonates. Umbilical venous catheters (UVCs) are associated with pleural effusion following abnormal placement in the left atrium or pulmonary veins due to venous obstruction. We report for the first time a case of right-sided ple...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-992174
更新日期:2007-11-01 00:00:00
abstract::The presence of the maternal warm antibody in pregnancy should not be ignored. As there is risk of both maternal and fetal anemia, both patients need to be followed for the development of such. Serial complete blood counts in the mother and treatment if significant fetal anemia develops should be considered. Serial am...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994196
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:Amplitude-integrated electroencephalography (aEEG) is a simplified method for continuous monitoring of brain activity in the neonatal intensive care unit (NICU). Our objective was to describe current aEEG use in the United States. STUDY DESIGN:An online survey was distributed to the American Academy of Pedia...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1395483
更新日期:2015-07-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999866
更新日期:1986-07-01 00:00:00
abstract::Premature closure of the foramen ovale is a rare cardiac anomaly. Severe right-sided heart failure accounts for the hepatomegaly, ascites, pleural and pericardial effusions, and generalized edema of these hydropic fetuses. Premature closure of the foramen ovale should be a part of the differential diagnosis when unexp...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994616
更新日期:1994-11-01 00:00:00
abstract::Infantile polycystic kidney disease (Potter's Type 1) is an autosomal recessive disorder that affects the kidneys and liver. Use of ultrasound to make the diagnosis prenatally is well documented and, in fact, it is advocated as a screening device for second-trimester identification of potentially affected fetuses. The...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999726
更新日期:1987-01-01 00:00:00
abstract::A patient with congenital antithrombin III deficiency and a history of thromboembolic events prior to pregnancy was successfully treated with subcutaneous heparin alone throughout two pregnancies. Although adjuvant antithrombin III infusions may have a role in the treatment of this disorder, especially in the peripart...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994748
更新日期:1993-07-01 00:00:00
abstract::Five cases of sirenomelia presented with rare manifestations are discussed. Three neonates were born alive and died within 2 to 12 hours after birth. One case was the offspring of a triple in vitro fertilization pregnancy with history of early intrauterine death of one of the triplets. The main features included fusio...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-835314
更新日期:2004-10-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999271
更新日期:1992-09-01 00:00:00
abstract::Small- to moderate-sized aortic thrombi in the sick newborn are frequently demonstrated, however, severe aortic thrombosis is rarely encountered. We report two newborn infants presenting with signs of decreased lower limb perfusion shortly after birth. An occlusive infrarenal aortic thrombus was demonstrated in both i...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2000-9975
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To analyze outcomes after second-stage labor beyond 3 hours and determine if prolonged second stages were intentional. STUDY DESIGN:Retrospective cohort analysis of maternal and neonatal outcomes in nulliparous women based on second-stage duration. Medical records were reviewed for management decisions in wo...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1314894
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE: This article determines the tolerance of neonatal intensive care unit (NICU)-based administration of RV5 in premature infants. This article also aims to compare the rate of clinically significant adverse events after RV5 immunization to the standard 2-month shot series and to historical controls who were not...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1698455
更新日期:2019-11-18 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999691
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abstract::We report a case with spontaneous rupture of the renal pelvis during pregnancy. A 34-year-old Japanese woman was referred at 20 weeks' gestation because of sudden severe right flank pain. She had severe colic pain radiating to the right lower abdomen with percussion tenderness at the right costovertebral angle and was...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2002-28489
更新日期:2002-05-01 00:00:00
abstract::In insulin dependent diabetic (IDDM) gestations, fetal pulmonary maturity is delayed in the presence of suboptimal glycemic control. Serum glycosylated hemoglobin (HbA1c) provides a means of assessing glycemic control. We evaluated maternal HbA1c in IDDM pregnancies at term undergoing amniocentesis for lung maturity t...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993868
更新日期:1999-01-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994119
更新日期:1997-03-01 00:00:00
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journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1670634
更新日期:2019-04-01 00:00:00
abstract::Limited research in young adults and immature animals suggests a detrimental effect of tobacco on bone during growth. We aimed to determine the adverse effects of maternal nicotine exposure during pregnancy and lactation on neonatal rat bone development, and to determine a protective effect of ascorbic acid. Gravid ra...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2006-951287
更新日期:2006-10-01 00:00:00
abstract::Objective We aimed to evaluate which patient-level factors influence mode of delivery among candidates for operative vaginal delivery. Study Design Cross-sectional study of candidates for operative vaginal delivery from 18 hospitals over 8 years. Probabilities of mode of delivery were estimated using hierarchical logi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1601441
更新日期:2017-08-01 00:00:00
abstract::We present a case of congenital parvovirus B19 infection in a term neonate manifested with isolated massive hydrothorax and mild anemia. Parvovirus B19 DNA was detected in maternal and neonatal blood as well as in pleural fluid despite lack of suggestive serology. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1085621
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE: This study aimed to the assess risk of respiratory morbidity in neonates born to women with gestational diabetes mellitus (GDM) delivered after labor compared with those delivered without exposure to labor. STUDY DESIGN: This is a secondary analysis of a prospective single-center cohort study of singleton p...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1716483
更新日期:2020-09-06 00:00:00
abstract:OBJECTIVE:To evaluate the association between midpregnancy cervical length and postterm delivery and cesarean delivery during labor. STUDY DESIGN:In a multicenter cohort study, cervical length was measured in low-risk singleton pregnancies between 16 and 22 weeks of gestation. From this cohort, we identified nulliparo...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究
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更新日期:2016-01-01 00:00:00
abstract::Objective Our objective was to review the literature in relationship to diabetes in pregnancy in low and middle income countries. Study Design We reviewed the English language literature related to diabetes and obesity during pregnancy in low and middle income countries published over the last 20 years. Results The gl...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1584152
更新日期:2016-11-01 00:00:00