Clinical Tolerance of In-Neonatal Intensive Care Unit Administration of Rotavirus Vaccine.

Abstract:

OBJECTIVE: This article determines the tolerance of neonatal intensive care unit (NICU)-based administration of RV5 in premature infants. This article also aims to compare the rate of clinically significant adverse events after RV5 immunization to the standard 2-month shot series and to historical controls who were not immunized. STUDY DESIGN: This is a retrospective case-control study of 201 premature infants immunized with RV5. Infants were evaluated for clinically significant events 7 days before and after immunization and were compared with events after the 2-month shot series and to 189 historical controls. Wilcoxon signed rank test and McNemar's test were used for all paired analysis. RESULTS: There was no increase in number of infants with clinically significant adverse events when comparing after RV5 to prior to RV5, after the 2-month shot series, or to the historical controls. CONCLUSION: RV5 is well tolerated in premature infants and does not result in clinically significant adverse events when administered in NICU-hospitalized infants.

journal_name

Am J Perinatol

authors

Briggs-Steinberg C,Aboudi D,Hodson G,Shah S

doi

10.1055/s-0039-1698455

subject

Has Abstract

pub_date

2019-11-18 00:00:00

eissn

0735-1631

issn

1098-8785

pub_type

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