The role of novel biomarkers in early diagnosis and prognosis of acute kidney injury in newborns.

Abstract:

:Acute kidney injury (AKI) refers to the rapid loss of renal function. In clinical practice, AKI is common among hospitalized patients of all age groups including neonates and remains an important cause of morbidity and mortality due to its late diagnosis and therefore delayed therapeutic intervention. Although the precise incidence of AKI in newborn is unknown, several studies have reported that 8 to 24% of all critically ill newborns in neonatal intensive care units may develop the condition. We aim at reviewing the existing literature on novel serum and urinary biomarkers and discuss their role in the early diagnosis and prognosis of AKI in newborns. Specifically, this review will focus on cystatin C (CysC), neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) in serum and on CysC, NGAL, kidney injury molecule-1, and IL-18 in urine.

journal_name

Am J Perinatol

authors

Argyri I,Xanthos T,Varsami M,Aroni F,Papalois A,Dontas I,Fanos V,Iacovidou N

doi

10.1055/s-0032-1326985

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

347-52

issue

5

eissn

0735-1631

issn

1098-8785

journal_volume

30

pub_type

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