Neonatal cord blood subsets and cytokine response to bacterial antigens.

Abstract:

:We compared lymphocyte subsets and cytokine responses to bacteria among term, preterm infants, and adults. Lymphocyte subset percentages in cord blood (22 preterm, 27 term neonates) and peripheral blood from 21 adults and cytokine/chemokine interleukin (IL)-6, IL-8, IL-10, IL-12, interferon gamma (IFN gamma) responses to Escherichia coli, group B Streptococcus (GBS), Staphylococcus epidermidis, and Lactobacillus plantarum (Lp299v) were assessed by flow cytometry. Preterm compared with term infants had increased CD8 (+) T cells (p = 0.02) and reduced naïve CD4 (+) T cells (p < 0.0001). Memory T and natural killer (NK) T cells were reduced (p < 0.001) in neonates; NK and CD56 (+)161 (+) NK cells were increased (p < 0.001). CD56 (+)CD8 (+) NK cells were higher in preterm compared with term infants. Despite individual exceptions, cytokine responses in neonates were weaker than adults except for IL-8 response to E. coli in preterm and IL-12 response to Lp299v in term infants. IL-10 responses were weaker in preterm (p = 0.01) and term (p = 0.005) infants to S. epidermidis and to E. coli (p = 0.03 for both) compared with adults. Differences in regulatory subpopulations of NK and T cells between neonates and adults and term compared with preterm infants were observed. These differences rather than intrinsic functional deficiency may account for neonatal cytokine responses to bacteria.

journal_name

Am J Perinatol

authors

Peoples JD,Cheung S,Nesin M,Lin H,Tatad AM,Hoang D,Perlman JM,Cunningham-Rundles S

doi

10.1055/s-0029-1220788

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

647-57

issue

9

eissn

0735-1631

issn

1098-8785

journal_volume

26

pub_type

杂志文章
  • Fetal and neonatal cytopenias: what have we learned?

    abstract::Rh disease has largely disappeared as a result of prophylaxis with anti-D. However, the cases that remain are more complicated with a combination of novel challenges with regard to in utero management with transfusion and its effects on the course of the neonate, both early and late. Thrombocytopenia in the neonate ca...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-45392

    authors: Bussel JB

    更新日期:2003-11-01 00:00:00

  • Obstetric Recommendations in American Congress of Obstetricians and Gynecologists Practice Bulletins versus UpToDate: a comparison.

    abstract:OBJECTIVE:To compare the obstetric recommendations in American Congress of Obstetricians and Gynecologists (ACOG) practice bulletins (PB) with similar topics in UpToDate (UTD). STUDY DESIGN:We accessed all obstetric PB and cross-searched UTD (May 1999-May 2013). We analyzed only the PB which had corresponding UTD chap...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1396684

    authors: Myer EN,Too GT,Hammad IA,Babbar S,Martin CE,Hill JB,Blackwell SB,Chauhan SP

    更新日期:2015-04-01 00:00:00

  • Obestatin Reduces Intestinal Damage in Experimental Necrotizing Enterocolitis in Newborn Rats.

    abstract:OBJECTIVE:To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). STUDY DESIGN:Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC a...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676491

    authors: Korkut S,Özdemir A,Yay AH,Yalçın B,Ceylan M,Korkmaz L,Yazıcı C,Güntürk İ,Kurtoğlu S

    更新日期:2019-09-01 00:00:00

  • Rehospitalization in Infants Born 

    abstract:OBJECTIVE:This study aims to determine risk factors for rehospitalization in extremely premature infants. STUDY DESIGN:A retrospective cohort study of 157 infants born < 29 weeks' gestational age assessing risk factors for rehospitalization through 2 years of life. RESULTS:Multivariable logistic regression showed tha...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0035-1555123

    authors: Taylor JB,Go MA,Nyp MF,Legino J,Norberg M,Dai H,Truog WE

    更新日期:2016-01-01 00:00:00

  • Oscillometric and intra-arterial blood pressure in preterm and term infants: extent of discrepancy and factors associated with inaccuracy.

    abstract:OBJECTIVE:Securing an arterial line to monitor continuous blood pressure (BP) is difficult in infants. We aimed to reveal the extent of discrepancies between oscillometric and direct BP. STUDY DESIGN:Infants who required continuous BP monitoring were prospectively enrolled. Direct and indirect BP were simultaneously r...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0034-1383851

    authors: Shimokaze T,Akaba K,Saito E

    更新日期:2015-02-01 00:00:00

  • Outpatient oral misoprostol for prolonged pregnancies: a pilot investigation.

    abstract:UNLABELLED:We evaluated the effectiveness of oral misoprostol for outpatient cervical ripening and labor induction in prolonged pregnancies. We performed a randomized, double-blind, placebo-controlled study of women at 40 to 42 weeks' gestation with well-dated pregnancies, singleton gestations, Bishop scores less than ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0029-1220790

    authors: Gaffaney CA,Saul LL,Rumney PJ,Morrison EH,Thomas S,Nageotte MP,Wing DA

    更新日期:2009-10-01 00:00:00

  • Ethical Cultures in Perinatal Care: Do They Exist? Correlation of Provider Attitudes with Periviability Practices at Six Centers.

    abstract:OBJECTIVE: This study aimed to compare attitudes of providers regarding perinatal management and outcomes for periviable newborns of caregivers at centers with higher resuscitation (HR) and lower resuscitation (LR) rates in the delivery room. STUDY DESIGN: All obstetric and neonatal clinical providers at six U.S. site...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1709128

    authors: Lawrence C,Laventhal N,Fritz KA,Carlos C,Famuyide M,Tonismae T,Hayslett D,Coleman T,Jain M,Edmonds BT,Leuthner S,Andrews B,Feltman DM

    更新日期:2020-04-15 00:00:00

  • The frequency of hypoglycemia in full-term large and small for gestational age newborns.

    abstract::Although various authors recommend screening for hypoglycemia in large for gestational age (LGA) and small for gestational age (SGA) newborns, the frequency of hypoglycemia in these infants, using a recent definition of hypoglycemia, and the proper duration of screening are not documented. We determined chromogen test...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994649

    authors: Holtrop PC

    更新日期:1993-03-01 00:00:00

  • Midpregnancy Cervical Length in Nulliparous Women and its Association with Postterm Delivery and Intrapartum Cesarean Delivery.

    abstract:OBJECTIVE:To evaluate the association between midpregnancy cervical length and postterm delivery and cesarean delivery during labor. STUDY DESIGN:In a multicenter cohort study, cervical length was measured in low-risk singleton pregnancies between 16 and 22 weeks of gestation. From this cohort, we identified nulliparo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0035-1556067

    authors: van der Ven AJ,van Os MA,Kleinrouweler CE,Verhoeven CJ,de Miranda E,Bossuyt PM,de Groot CJ,Haak MC,Pajkrt E,Mol BW,Kazemier BM

    更新日期:2016-01-01 00:00:00

  • The evidence for abandoning the amniotic fluid index in favor of the single deepest pocket.

    abstract::This study assessed whether the amniotic fluid index (AFI) or the single deepest pocket (SDP) is the best technique to estimate amniotic fluid volume. The AFI and SDP were compared to a dye-determined or directly measured amniotic fluid volume. A PUBMED search from 1990 to 2006 was conducted using the search terms "si...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-986689

    authors: Magann EF,Chauhan SP,Doherty DA,Magann MI,Morrison JC

    更新日期:2007-10-01 00:00:00

  • Impact of oral versus intravenous ibuprofen on neurodevelopmental outcome: a randomized controlled parallel study.

    abstract:OBJECTIVE:Although neurodevelopmental outcomes related to the management of patent ductus arteriosus with intravenous indomethacin and ibuprofen are known, little data on the long-term effects of oral ibuprofen can be found in the literature. METHOD:A follow-up study of 99 infants with birth weight ≤ 1,500 g and gesta...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0033-1333667

    authors: Eras Z,Gokmen T,Erdeve O,Ozyurt BM,Saridas B,Dilmen U

    更新日期:2013-11-01 00:00:00

  • Health Care Utilization after NICU Discharge and Neurodevelopmental Outcome in the First 2 Years of Life in Preterm Infants.

    abstract:OBJECTIVE: The objective of this study was to determine predictors of health care utilization and its association with neurodevelopmental outcome in a recent cohort of preterm infants. STUDY DESIGN: A total of 405 infants (born 2008-2011) seen in neonatal intensive care unit (NICU) follow-up were compared for use of h...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0037-1608678

    authors: Patra K,Greene MM

    更新日期:2018-04-01 00:00:00

  • Does individual room implemented family-centered care contribute to mother-infant interaction in preterm deliveries necessitating neonatal intensive care unit hospitalization?

    abstract::The aim of the study was to investigate the effect of individual room care in the neonatal intensive care unit (NICU) on the factors that influence mother-preterm infant interaction. Mothers in group I had hospitalization with their preterm infants in an individual room in the NICU. Mothers in group II were not hospit...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究

    doi:10.1055/s-0028-1095186

    authors: Erdeve O,Arsan S,Canpolat FE,Ertem IO,Karagol BS,Atasay B,Yurdakok M,Tekinalp G,Turmen T

    更新日期:2009-02-01 00:00:00

  • A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants.

    abstract:OBJECTIVE:To identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. STUDY DESIGN:We reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative reco...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0038-1677503

    authors: Spiegel AM,Li J,Oehlert JW,Mayo JA,Quaintance CC,Girsen AI,Druzin ML,El-Sayed YY,Shaw GM,Stevenson DK,Gibbs RS

    更新日期:2019-12-01 00:00:00

  • Fetal echocardiographic screening of pregnancies of mothers with anti-Ro and/or anti-La antibodies.

    abstract::The objectives of this study are to assess the incidence of congenital complete heart block (CCHB) in pregnant women who are anti-Ro and/or La positive. Between January, 1988 and July 1997, 118 pregnancies in 105 women were assessed by fetal echo at 18, 24, and 32 weeks' gestation. Of these 105, 96 had no history of a...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2002-23555

    authors: Gladman G,Silverman ED,Yuk-Law,Luy L,Boutin C,Laskin C,Smallhorn JF

    更新日期:2002-02-01 00:00:00

  • Heparin therapy for congenital antithrombin III deficiency in pregnancy.

    abstract::A patient with congenital antithrombin III deficiency and a history of thromboembolic events prior to pregnancy was successfully treated with subcutaneous heparin alone throughout two pregnancies. Although adjuvant antithrombin III infusions may have a role in the treatment of this disorder, especially in the peripart...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994748

    authors: Neerhof MG,Krewson DP,Haut M,Librizzi RJ

    更新日期:1993-07-01 00:00:00

  • Feasibility of postpartum rapid hospital discharge: a study from a community hospital population.

    abstract::We have examined the safety and efficacy of an early postpartum discharge program in 289 patients who were identified prior to delivery and counseled and educated for discharge 12 to 36 hours after delivery. A total of 55% of the study patients were able to be discharged early. There were 4.3% significant maternal pro...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994768

    authors: Welt SI,Cole JS,Myers MS,Sholes DM Jr,Jelovsek FR

    更新日期:1993-09-01 00:00:00

  • Resolving polyhydramnios. A sign of improved fetal status.

    abstract::Four cases of transient polyhydramnios are reviewed. It is proposed that by taking note of changes in amniotic fluid volume, one can more accurately assess a fetal-maternal unit that is affected by a number of specific disease processes. ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999656

    authors: Hill LM

    更新日期:1988-01-01 00:00:00

  • Accurate gestational dating: revisited.

    abstract::Using first trimester fetal crown-rump length (CRL) measurements as the criterion for gestational dating, rather than menstrual history or neonatal gestational age evaluation after birth, may be a more accurate way of evaluating the accuracy of second or third trimester ultrasonic measurements for gestational age esti...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994606

    authors: Ott WJ

    更新日期:1994-11-01 00:00:00

  • Sonographic measurement of the fetal iliac bone: growth and relation to femur length in assessment of gestational age.

    abstract::Diagnostic ultrasonography has given us the opportunity to diagnose several congenital malformations in utero. Skeletal dysplasias is a heterogeneous group of disorders of the skeleton. Although disorders of bone growth are often diagnosed in utero, it is usually a general diagnosis because the exact syndrome cannot b...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-994638

    authors: Jaffe R,Santolaya J,Warsof SL

    更新日期:1993-03-01 00:00:00

  • Fetal and neonatal mortality among twin gestations in a Canadian population: the effect of intrapair birthweight discordance.

    abstract::The purpose of this study was to examine the association between intrapair birthweight discordance and fetal and neonatal mortality. This was a historical cohort study, using the Statistics Canada linked birth-infant death file. Twin births in Canada (excluding Ontario) for the period 1986-1997 were studied. Outcome m...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2005-870899

    authors: Wen SW,Fung KF,Huang L,Demissie K,Joseph KS,Allen AC,Kramer MS,Fetal and Infant Health Group of the Canadian Perinatal Surveillance System.

    更新日期:2005-07-01 00:00:00

  • Prenatal diagnosis of crossed ectopic multicystic kidney.

    abstract::The combination of multicystic kidney and crossed ectopia is very rare. In most of the affected children, diagnosis has been made postnatally by ultrasonographic examination to evaluate a palpated abdominal mass. We describe the third male newborn reported in the literature with a prenatally diagnosed crossed ectopic ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-994073

    authors: Maayan A,Mashiach R,Kessler OJ,Meizner I,Merlob P

    更新日期:1998-08-01 00:00:00

  • Development of pulmonary lipophilic antioxidants and peroxidizable lipids during lung maturation.

    abstract::The objective of this article is to test whether the concentration of potentially oxidizable lipids (polyunsaturated fatty acids [PUFA], total and free cholesterol) and lipophilic antioxidants (plasmalogens, vitamin E) in the fetal lung correlate with lung maturation (P/S ratio). In amniotic fluid palmitic/stearic aci...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-993952

    authors: Rüdiger M,Haupt R,Wauer RR,Rüstow B

    更新日期:1998-05-01 00:00:00

  • Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial.

    abstract:OBJECTIVE:The objective of this study was to evaluate the effectiveness of vaginal progesterone in reducing adverse neonatal outcome due to preterm birth (PTB) in low-risk pregnant women with a short cervical length (CL). STUDY DESIGN:Women with a singleton pregnancy without a history of PTB underwent CL measurement a...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-0035-1547327

    authors: van Os MA,van der Ven AJ,Kleinrouweler CE,Schuit E,Kazemier BM,Verhoeven CJ,de Miranda E,van Wassenaer-Leemhuis AG,Sikkema JM,Woiski MD,Bossuyt PM,Pajkrt E,de Groot CJ,Mol BW,Haak MC

    更新日期:2015-08-01 00:00:00

  • Physiologic changes induced by endotracheal instillation and suctioning in critically ill preterm infants with and without sedation.

    abstract::Endotracheal instillation and subsequent suctioning produces fluctuations of intracranial pressure (ICP), mean arterial pressure (MAP), and cerebral perfusion pressure (CPP) in sick preterm infants. In an attempt to observe if these fluctuations could be minimized using sedation, we studied a group of seven sick mecha...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999841

    authors: Ninan A,O'Donnell M,Hamilton K,Tan L,Sankaran K

    更新日期:1986-04-01 00:00:00

  • Diabetes during Pregnancy in Low- and Middle-Income Countries.

    abstract::Objective Our objective was to review the literature in relationship to diabetes in pregnancy in low and middle income countries. Study Design We reviewed the English language literature related to diabetes and obesity during pregnancy in low and middle income countries published over the last 20 years. Results The gl...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1584152

    authors: Goldenberg RL,McClure EM,Harrison MS,Miodovnik M

    更新日期:2016-11-01 00:00:00

  • Association of midgestational paraoxonase 1 activity with pregnancies complicated by preeclampsia.

    abstract::The antioxidant enzyme paraoxonase 1 is a marker of oxidative stress and has been implicated in the pathogenesis of preeclampsia. Our objective was to determine if an association exists between low paraoxonase 1 activity at midgestation and the development of preeclampsia. We conducted a case-control study of 50 women...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0029-1236438

    authors: Baker AM,Klein RL,Haeri S,Moss KL,Boggess KA

    更新日期:2010-03-01 00:00:00

  • The Impact of Hypernatremia in Preterm Infants on Neurodevelopmental Outcome at 18 Months of Corrected Age.

    abstract:OBJECTIVE: The study objective was to assess the correlation between hypernatremia during the first week of life and neurodevelopmental outcomes at 18 months of corrected age in premature infants. STUDY DESIGN: A retrospective observational study of preterm infants born at less than 32 weeks of gestation who had a neu...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-0040-1716845

    authors: Howell HB,Lin M,Zaccario M,Kazmi S,Sklamberg F,Santaniello N,Wachtel E

    更新日期:2020-09-24 00:00:00

  • Acute onset of severe hemolysis, elevated liver enzymes, and low platelet count syndrome in a patient with a partial hydatidiform mole at 17 weeks gestation.

    abstract::Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the on...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2006-934093

    authors: Sherer DM,Dalloul M,Stimphil R,Hellmann M,Khoury-Collado F,Osho J,Fomitcheva L,Brennan KJ,Abulafia O

    更新日期:2006-04-01 00:00:00

  • The prognosis of Rh-affected pregnancies: an exception to the usual rule.

    abstract::A patient with a homozygous marital partner had three progressively less seriously involved RH-positive babies after a fetal demise due to erythroblastosis. Only the first of the three required fetal transfusions. All were Rh genotypically identical. The case is presented for interest and to illustrate an exception to...

    journal_title:American journal of perinatology

    pub_type: 杂志文章

    doi:10.1055/s-2007-999655

    authors: Perkins RP

    更新日期:1988-01-01 00:00:00