Development of pulmonary lipophilic antioxidants and peroxidizable lipids during lung maturation.


:The objective of this article is to test whether the concentration of potentially oxidizable lipids (polyunsaturated fatty acids [PUFA], total and free cholesterol) and lipophilic antioxidants (plasmalogens, vitamin E) in the fetal lung correlate with lung maturation (P/S ratio). In amniotic fluid palmitic/stearic acid (P/S) ratio, concentrations of PUFA, total and free cholesterol, vitamin E, and plasmalogens were measured. Ratio of PUFA to stearic acid (PUFA/S ratio) was determined in lung effluent of 15 preterm infants with IRDS and compared with values from 15 term healthy infants. Concentrations of plasmalogens, PUFA, total and free cholesterol increase significantly with increasing P/S ratio. No correlation of vitamin E with lung maturation has been found. The PUFA/S ratio is significantly lower in lung effluent of preterm (0.79 +/- 0.27) when compared with term infants (2.02 +/- 0.38). Our results suggest that the higher susceptibility of preterm infants for oxidative lung injury is not caused by an unfavorable ratio of oxidizable lipids to lipophilic antioxidants in surfactant, but rather by a lower amount of PUFA containing surfactant lipids. Our results are in accordance with data from Sosenko et al. who have shown that high levels of PUFA in the rat lung have a protective effect against oxygen-induced lung damage.


Am J Perinatol


Rüdiger M,Haupt R,Wauer RR,Rüstow B




Has Abstract


1998-05-01 00:00:00












  • Nonimmune hydrops fetalis due to congenital syphilis associated with negative intrapartum maternal serology screening.

    abstract::We present an unusual case, in which a woman presenting with markedly decreased fetal movements at 29 weeks gestation following a recent increase in fundal height was noted sonographically to have fetal hydrops consisting of scalp edema, marked hepatomegaly, ascites, and polyhydramnios. No lethal structural congenital...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Levine Z,Sherer DM,Jacobs A,Rotenberg O

    更新日期:1998-04-01 00:00:00

  • The Impact of Sperm and Egg Donation on the Risk of Pregnancy Complications.

    abstract:OBJECTIVE:The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation. MATERIALS AND METHODS:This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (S...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Fishel Bartal M,Sibai BM,Bart Y,Shina A,Mazaki-Tovi S,Eisen IS,Hendler I,Baum M,Schiff E

    更新日期:2019-01-01 00:00:00

  • Incidence and severity of intraventricular hemorrhage: 1981-1984.

    abstract::We have examined the trend in the incidence and mortality of intraventricular hemorrhage (IVH) in low birthweight infants from 1981 through 1984. During this time we admitted 407 infants in the first week of life with a birthweight less than or equal to 1500 gm in whom a cranial ultrasonogram or autopsy had been perfo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Batton DG,DeWitte DB,Boal DK,Nardis EE,Maisels MJ

    更新日期:1986-10-01 00:00:00

  • The significance of a positive fetal fibronectin in the setting of a normal cervical length in twin pregnancies.

    abstract::To estimate the risk of preterm birth in asymptomatic women with twin pregnancies with a normal cervical length (CL) and a positive fetal fibronectin (fFN), we reviewed a retrospective cohort of twin pregnancies delivered in our practice from 2005 to 2010. Patients were screened from 22 to 32 weeks with CL and fFN at ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Fox NS,Rebarber A,Roman AS,Klauser CK,Saltzman DH

    更新日期:2012-04-01 00:00:00

  • The effects of pH and osmolality on bacterial growth in amniotic fluid in a laboratory model.

    abstract::In studying the effects of amniotic fluid on bacterial growth in a laboratory model, we noted that the pH of the fluid appeared to exert an independent effect. This study was designed to test the ability to control the growth of Escherichia coli in amniotic fluid simply by controlling two important growth conditions, ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Silver HM,Siler-Khodr T,Prihoda TJ,Gibbs RS

    更新日期:1992-03-01 00:00:00

  • Fetal and neonatal mortality among twin gestations in a Canadian population: the effect of intrapair birthweight discordance.

    abstract::The purpose of this study was to examine the association between intrapair birthweight discordance and fetal and neonatal mortality. This was a historical cohort study, using the Statistics Canada linked birth-infant death file. Twin births in Canada (excluding Ontario) for the period 1986-1997 were studied. Outcome m...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Wen SW,Fung KF,Huang L,Demissie K,Joseph KS,Allen AC,Kramer MS,Fetal and Infant Health Group of the Canadian Perinatal Surveillance System.

    更新日期:2005-07-01 00:00:00

  • Coagulation and fibrinolytic parameters in normal pregnancy and in pregnancy complicated by intrauterine growth retardation.

    abstract::The objective of this article is to evaluate the plasma levels of coagulation and fibrinolysis parameters in the third trimester of gestation and 72 hr postdelivery. Antithrombin III (ATIII), thrombin-antithrombin III complexes (TAT), heparin cofactor II (HCII), protein C (PC), protein S (PS), tissue plasminogen activ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Bellart J,Gilabert R,Fontcuberta J,Carreras E,Miralles RM,Cabero L

    更新日期:1998-02-01 00:00:00

  • Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications.

    abstract:OBJECTIVE:Adding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also redu...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Ausbeck EB,Jauk VC,Boggess KA,Saade GR,Longo S,Clark EAS,Esplin S,Cleary K,Wapner R,Letson K,Owens M,Abramovici A,Ambalavanan N,Szychowski JM,Andrews W,Tita ATN,Cesarean Section Optimal Antibiotic Prophylaxis Trial Consor

    更新日期:2019-07-01 00:00:00

  • Aplasia cutis congenita in an infant of an initial triplet gestation: a case report.

    abstract::Aplasia cutis congenita (ACC) is the clinical manifestation of an uncommon group of skin disorders. One postulated etiology is disseminated intravascular coagulation from release of thrombogenic maternal arising from placental injury or fetal demise. This leads to disruption of the ectodermal blood supply responsible ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Da-Silva SS,Fagbongbe EO

    更新日期:1999-01-01 00:00:00

  • Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings.

    abstract:OBJECTIVE:We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center. STUDY DESIGN:We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demograp...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Black CG,Tavares L,Stachel A,Ratner AJ,Randis TM

    更新日期:2019-09-01 00:00:00

  • AmniSure placental alpha microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes.

    abstract::The purpose of this study was to compare the AmniSure rapid immunoassay with standard methods for diagnosing rupture of fetal membranes. Patients presenting with signs/symptoms of membrane rupture between 15 and 42 weeks of gestation were invited to participate. Standard/control methods were performed to establish a d...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Cousins LM,Smok DP,Lovett SM,Poeltler DM

    更新日期:2005-08-01 00:00:00

  • Improvement of conventional transcutaneous bilirubinometry results in term newborn infants.

    abstract::This prospective study was performed to determine a way to improve conventional transcutaneous bilirubinometry results in healthy term newborn infants. In 118 infants during phototherapy (group A), and in 118 infants without phototherapy (group B), bilirubin determinations were done in duplicate using the Minolta AirS...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Felc Z

    更新日期:2005-05-01 00:00:00

  • B-type natriuretic peptide: biomarker of persistent pulmonary hypertension of the newborn?

    abstract:OBJECTIVE:We assessed the utility of plasma B-type natriuretic peptide (BNP) in infants with persistent pulmonary hypertension of the newborn (PPHN) in the prediction of inhaled nitric oxide (iNO) requirement. METHODS:This prospective study involved neonates (gestational age ≥ 34 weeks) with PPHN and confirmatory echo...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Shah N,Natarajan G,Aggarwal S

    更新日期:2015-09-01 00:00:00

  • Proficiency of Laryngeal Mask Airway Insertion Skill in NRP Certified Providers.

    abstract:OBJECTIVE: In 2015, Neonatal Resuscitation Program (NRP) recommended laryngeal mask airway (LMA) as an alternative to the endotracheal tube (ETT) in situations where the provider is "unable to intubate and unable to ventilate." LMA insertion is being taught in the NRP routinely. However, endotracheal intubation is the ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Mani S,Rawat M

    更新日期:2020-11-29 00:00:00

  • Remifentanil analgesia during laser treatment for retinopathy of prematurity: a practical approach in neonatal intensive care unit.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a significant cause of childhood blindness. AIM:The aim of this study is to determine the feasibility of remifentanil analgesia during laser treatment of ROP performed in the neonatal intensive care unit (NICU). PATIENTS AND METHODS:Remifentanil was infused continuously ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Demirel N,Bas AY,Kavurt S,Celik IH,Yucel H,Turkbay D,Hekimoğlu E,Koc O

    更新日期:2014-11-01 00:00:00

  • Do postnatal glucocorticoids and retinopathy of prematurity relate?

    abstract::To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Termote J,Schalij-Delfos NE,Donders AR,Cats BP

    更新日期:2000-01-01 00:00:00

  • The use of clinical, biochemical, and ultrasound parameters for the diagnosis of intrauterine growth retardation.

    abstract::Fifty-four pregnant patients referred for nonstress testing with findings suggestive of intrauterine growth retardation (IUGR) were followed with serial biochemical determinations and ultrasound evaluations. Confirmation of IUGR was made in 18 of the neonates based on body weights below the 10th percentile. Stepwise d...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Hassan MM,Bottoms SF,Mariona FG,Syner FN,Simkowski KM,Sokol RJ

    更新日期:1987-07-01 00:00:00

  • Does perinatal phenobarbital exposure affect developmental outcome at age 2?

    abstract::The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participate; 48 mothers declined entry. Before delivery, pharmacy randomize...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thorp JA,O'Connor M,Jones AM,Hoffman EL,Belden B

    更新日期:1999-01-01 00:00:00

  • Decreased Glutathione S-transferase Level and Neonatal Hyperbilirubinemia Associated with Glucose-6-phosphate Dehydrogenase Deficiency: A Perspective Review.

    abstract::Classically, genetically decreased bilirubin conjugation and/or hemolysis account for the mechanisms contributing to neonatal hyperbilirubinemia associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, these mechanisms are not involved in most cases of this hyperbilirubinemia. Additional plausible...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Al-Abdi SY

    更新日期:2017-02-01 00:00:00

  • Comparison of maternal risk factors between placental abruption and placenta previa.

    abstract::The purpose of this study was to compare risk factors between placental abruption and placenta previa among primiparous and multiparous singleton pregnancies. We analyzed data from a population-based retrospective cohort with singleton pregnancies in the United States for 1995 to 2000. Maternal risk factors for placen...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Yang Q,Wen SW,Phillips K,Oppenheimer L,Black D,Walker MC

    更新日期:2009-04-01 00:00:00

  • Clinical Indicators of Late-Onset Sepsis Workup in Very Low-Birth-Weight Infants in the Neonatal Intensive Care Unit.

    abstract::Background Late-onset sepsis (LOS) in very low-birth-weight (VLBW) infants is associated with significant morbidity and mortality. Objectives To determine the incidence of LOS workup, association, and predictive value of clinical indicators leading to culture-positive versus culture-negative sepsis workup. Methods All...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Das A,Shukla S,Rahman N,Gunzler D,Abughali N

    更新日期:2016-07-01 00:00:00

  • The birth of Caesar and the cesarean misnomer.

    abstract::Although cesarean section is one of the most ancient surgical procedures, the origin of its name remains obscure. The term, however, did not originate because of the birth of the Roman Emperor Julius Caesar through this route. In fact, historians are certain that Julius Caesar was not delivered by the dangerous cesare...

    journal_title:American journal of perinatology

    pub_type: 历史文章,杂志文章


    authors: Raju TN

    更新日期:2007-11-01 00:00:00

  • Use of quantitative amniotic fluid phosphatidylglycerol as a criterion for fetal lung maturation.

    abstract::Phosphatidylglycerol (PG) in amniotic fluid was quantitatively measured by thin-layer chromatography (TLC) in 941 amniotic fluid samples and related to the presence or absence of respiratory distress syndrome (RDS) in neonates born within 7 days of the amniocentesis. In 639 case tests with PG 1 nmol/ml or more of amni...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Tsao FH,Zachman RD

    更新日期:1992-01-01 00:00:00

  • Gestational Weight Gain: Association with Adverse Pregnancy Outcomes.

    abstract::Background It is unclear how adherence to the Institute of Medicine's (IOM) guidelines for weight gain affects pregnancy outcomes. Objective We investigated how weight gain outside the IOM's recommendations affects the risks of adverse pregnancy outcomes. Study Design We performed a secondary analysis of a prospective...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Hannaford KE,Tuuli MG,Odibo L,Macones GA,Odibo AO

    更新日期:2017-01-01 00:00:00

  • The rate of severe preeclampsia is increased in triplet as compared to twin gestations.

    abstract::The objective of this study was to determine if the rate of preeclampsia is increased in triplet as compared to twin gestations. Fifty-three triplet pregnancies between 1986 and 1993 at The New York Hospital-Cornell Medical Center were reviewed. These were matched for maternal age, parity, and race to twin gestations ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Mastrobattista JM,Skupski DW,Monga M,Blanco JD,August P

    更新日期:1997-05-01 00:00:00

  • High-frequency jet ventilation improves gas exchange in extremely immature infants with evolving chronic lung disease.

    abstract::Extremely preterm infants often develop chronic lung disease (CLD) characterized by heterogeneous aeration; poorly supported, floppy airways; and air trapping. High-frequency jet ventilation (HFJV) with high end-expiratory pressure (optimal lung volume strategy [OLVS]) may improve airway patency, lead to better gas di...

    journal_title:American journal of perinatology

    pub_type: 临床试验,杂志文章


    authors: Plavka R,Dokoupilová M,Pazderová L,Kopecký P,Sebron V,Zapadlo M,Keszler M

    更新日期:2006-11-01 00:00:00

  • Normal Point of Care Glucose Values after Birth in the Well-Baby Nursery.

    abstract:OBJECTIVE:Normal initial blood glucose values in healthy newborns are not well defined and are subject to controversy. Despite substantive research, there is no single initial value of glucose that can be used with certainty of safety in newborns, and thus various protocols and cutoffs have been proposed. STUDY DESIGN...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Levy-Khademi F,Perry A,Klinger G,Herscovici T,Kasirer Y,Bromiker R

    更新日期:2019-01-01 00:00:00

  • First trimester chorionic villus sampling in twin gestations.

    abstract::First-trimester prenatal diagnosis was offered to 104 twin pregnancies mainly for advanced maternal age and cytogenetic evaluation of a new fertilization technique. Chorionic villus sampling (CVS) was performed transcervically (35%), transabdominally (23%), or by combination of these two techniques (42%). Although no ...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: De Catte L,Liebaers I,Foulon W,Bonduelle M,Van Assche E

    更新日期:1996-10-01 00:00:00

  • Rare manifestations of sirenomelia syndrome: a report of five cases.

    abstract::Five cases of sirenomelia presented with rare manifestations are discussed. Three neonates were born alive and died within 2 to 12 hours after birth. One case was the offspring of a triple in vitro fertilization pregnancy with history of early intrauterine death of one of the triplets. The main features included fusio...

    journal_title:American journal of perinatology

    pub_type: 杂志文章


    authors: Drossou-Agakidou V,Xatzisevastou-Loukidou C,Soubasi V,Kostopoulou E,Laporda A,Pantzaki A,Agelidou S,Kremenopoulos G

    更新日期:2004-10-01 00:00:00

  • The surfactants.

    abstract::Surfactants have been routinely used since 1990 for the treatment of respiratory distress syndrome (RDS). The use of surfactant has coincided with a decrease in mortality in infants due to RDS. This review focuses on clinical aspects of surfactant use. New information, particularly effects of ventilatory styles on sur...

    journal_title:American journal of perinatology

    pub_type: 杂志文章,评审


    authors: Kallapur S,Ikegami M

    更新日期:2000-01-01 00:00:00